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Chemical Compound Review

L-guluronate     (2R,3S,4S,5S)-2,3,4,5- tetrahydroxy-6-oxo...

Synonyms: AC1OAGUS, CHEBI:33817, CPD-10583
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Disease relevance of L-Guluronic acid

 

High impact information on L-Guluronic acid

  • When the clone was mobilized to a P. aeruginosa algG mutant that produced alginate as polymannuronate due to its C5-epimerase defect, complementation was observed and the alginate from the recombinant strain contained L-guluronate as determined by proton nuclear magnetic resonance spectroscopy [2].
  • We previously identified a gene called algG in the alginate biosynthetic operon that is required for incorporation of L-guluronate residues into alginate [3].
 

Biological context of L-Guluronic acid

  • Expression of algG from a plasmid inan algG (i.e., polymannuronate-producing) mutant of P. aeruginosa restored production of an alginate containing L-guluronate residues [3].

References

  1. Identification of algI and algJ in the Pseudomonas aeruginosa alginate biosynthetic gene cluster which are required for alginate O acetylation. Franklin, M.J., Ohman, D.E. J. Bacteriol. (1996) [Pubmed]
  2. Characterization of algG encoding C5-epimerase in the alginate biosynthetic gene cluster of Pseudomonas fluorescens. Morea, A., Mathee, K., Franklin, M.J., Giacomini, A., O'Regan, M., Ohman, D.E. Gene (2001) [Pubmed]
  3. Pseudomonas aeruginosa AlgG is a polymer level alginate C5-mannuronan epimerase. Franklin, M.J., Chitnis, C.E., Gacesa, P., Sonesson, A., White, D.C., Ohman, D.E. J. Bacteriol. (1994) [Pubmed]
 
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