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Chemical Compound Review

Basdene     6-benzyl-2-sulfanylidene-1H- pyrimidin-4-one

Synonyms: AC1LEGI0, NSC-6508, AG-G-35009, SureCN2353689, ALBB-014144, ...
 
 
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Disease relevance of Basdene

 

High impact information on Basdene

  • Additionally, 2,6-pyridinediol and 6-benzyl-2-thiouracil have been identified as being potent inhibitors of UrdPase and dThdPase respectively [4].
  • ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil [2].
  • We report an 8-year-old girl treated with benzylthiouracil for Graves's disease who developed an ANCA-positive vasculitis with pulmonary hemorrhage [2].
  • Polarographic (DPP) activity of 6-benzyl-2-thiouracil (6-benzyl-2-mercapto-4-pyrimidinol, BTU) has been examined in a wide range of pH values and it has been discovered that the number and the height of observed peaks depends on composition of supporting electrolyte and concentration of the thiol [5].

References

  1. Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with benzylthiouracil therapy: report of the first case. Jarraya, F., Abid, M., Jlidi, R., Mkaouar, K., Mnif, M., Kharrat, M., Charfeddine, K., Kammoun, K., Ben Hmida, M., Hachicha, J. Nephrol. Dial. Transplant. (2003) [Pubmed]
  2. ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil. Thabet, F., Sghiri, R., Tabarki, B., Ghedira, I., Yacoub, M., Essoussi, A.S. Eur. J. Pediatr. (2006) [Pubmed]
  3. Toxic hepatitis induced by antithyroid drugs: four cases including one with cross-reactivity between carbimazole and benzylthiouracil. Sadoul, J.L., Canivet, B., Freychet, P. The European journal of medicine. (1993) [Pubmed]
  4. Structure-activity relationship of ligands of the pyrimidine nucleoside phosphorylases. Niedzwicki, J.G., el Kouni, M.H., Chu, S.H., Cha, S. Biochem. Pharmacol. (1983) [Pubmed]
  5. Pulsepolarographic determination of 6-benzyl-2-thio-uracil. Ciesielski, W., Kasprzak, M. Acta poloniae pharmaceutica. (2000) [Pubmed]
 
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