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Chemical Compound Review

ANCA     anthracene-9-carboxylic acid

Synonyms: Tocris-0963, ACMC-1BFF5, A89405_ALDRICH, AG-G-84790, CHEMBL1513985, ...
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Disease relevance of ANCA


Psychiatry related information on ANCA


High impact information on ANCA

  • The target antigen of anti-neutrophil cytoplasm antibodies (ACPA; also known as ANCA) was isolated by affinity chromatography from supernatants of human neutrophils, stimulated with phorbol ester to induce degranulation [8].
  • IC50 values were 8.8 nM for SN-38, 10 nM for CPT, 19 nM for 9-AC, 33 nM for TPT, and greater than 100 nM for CPT-11 [9].
  • RESULTS: SN-38 and CPT were more cytotoxic than 9-AC and TPT, and CPT-11 was almost inactive toward HT-29 cells [9].
  • In drug-induced DNA damage measured by alkaline elution drug concentrations producing 1000-rad-equivalents (C1000), values were 0.037 microM for SN-38, 0.051 microM for CPT, 0.085 microM for 9-AC, 0.28 microM for TPT, and greater than 1 microM for CPT-11 [9].
  • Furthermore, the ANCA-negative UC patients had an increase in the DR4 allele compared with ANCA-positive UC (P = 0.004) [10].

Chemical compound and disease context of ANCA


Biological context of ANCA

  • Thus, with the combination of a subclinical marker (ANCAs) and molecular genetic markers, genetic heterogeneity has been demonstrated within UC: ANCA-positive UC associated with DR2, and ANCA-negative UC likely associated with DR4 [10].
  • Pharmacokinetics showed a substantial interpatient variation of the area under the plasma concentration-time curve (AUC) of 9-AC [16].
  • A significant correlation was observed between the percentage decrease in WBC count and the AUC of 9-AC lactone (r(2) = 0.86) [16].
  • We conducted a phase I and pharmacokinetic study of the oral PEG-1000 formulation of 9-AC to define the maximum-tolerated dose, toxicity profiles, pharmacokinetic-dynamic relationships, and preliminary antitumor activity in patients with solid tumors [16].
  • Jejunal crypt cell survival was decreased in those mice given single doses of 9-AC ranging from 0.5-4.0 mg/kg and 12.5 Gy of total body radiation compared with those given 12.5 Gy of total body irradiation alone [4].

Anatomical context of ANCA


Associations of ANCA with other chemical compounds


Gene context of ANCA


Analytical, diagnostic and therapeutic context of ANCA


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  2. Consensus therapeutic regimens for ANCA-associated systemic vasculitis. The European Community Systemic Vasculitis Study Group. Rasmussen, N. Lancet (1997) [Pubmed]
  3. Is vasculitis in subacute bacterial endocarditis associated with ANCA? Wagner, J., Andrassy, K., Ritz, E. Lancet (1991) [Pubmed]
  4. Potentiation of murine MCa-4 carcinoma radioresponse by 9-amino-20(S)-camptothecin. Kirichenko, A.V., Rich, T.A., Newman, R.A., Travis, E.L. Cancer Res. (1997) [Pubmed]
  5. Incidence and disease associations of a proteinase 3-antineutrophil cytoplasmic antibody idiotype (5/7 Id) whose antiidiotype inhibits proteinase 3-antineutrophil cytoplasmic antibody antigen binding activity. Strunz, H.P., Csernok, E., Gross, W.L. Arthritis Rheum. (1997) [Pubmed]
  6. Hepatitis C knowledge among primary care residents: is our teaching adequate for the times? Coppola, A.G., Karakousis, P.C., Metz, D.C., Go, M.F., Mhokashi, M., Howden, C.W., Raufman, J.P., Sharma, V.K. Am. J. Gastroenterol. (2004) [Pubmed]
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  8. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. Lüdemann, J., Utecht, B., Gross, W.L. J. Exp. Med. (1990) [Pubmed]
  9. Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. Tanizawa, A., Fujimori, A., Fujimori, Y., Pommier, Y. J. Natl. Cancer Inst. (1994) [Pubmed]
  10. Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers. Yang, H., Rotter, J.I., Toyoda, H., Landers, C., Tyran, D., McElree, C.K., Targan, S.R. J. Clin. Invest. (1993) [Pubmed]
  11. 15-Deoxyspergualin in patients with refractory ANCA-associated systemic vasculitis: a six-month open-label trial to evaluate safety and efficacy. Birck, R., Warnatz, K., Lorenz, H.M., Choi, M., Haubitz, M., Grünke, M., Peter, H.H., Kalden, J.R., Göbel, U., Drexler, J.M., Hotta, O., Nowack, R., Van Der Woude, F.J. J. Am. Soc. Nephrol. (2003) [Pubmed]
  12. Clinical and histologic determinants of renal outcome in ANCA-associated vasculitis: A prospective analysis of 100 patients with severe renal involvement. de Lind van Wijngaarden, R.A., Hauer, H.A., Wolterbeek, R., Jayne, D.R., Gaskin, G., Rasmussen, N., Noël, L.H., Ferrario, F., Waldherr, R., Hagen, E.C., Bruijn, J.A., Bajema, I.M. J. Am. Soc. Nephrol. (2006) [Pubmed]
  13. The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. Kang, J.X., Man, S.F., Brown, N.E., Labrecque, P.A., Clandinin, M.T. Biochem. J. (1992) [Pubmed]
  14. Propylthiouracil-induced autoimmune syndromes: two distinct clinical presentations with different course and management. Aloush, V., Litinsky, I., Caspi, D., Elkayam, O. Semin. Arthritis Rheum. (2006) [Pubmed]
  15. ANCA glomerulonephritis and vasculitis: a Chapel Hill perspective. Falk, R.J., Nachman, P.H., Hogan, S.L., Jennette, J.C. Semin. Nephrol. (2000) [Pubmed]
  16. Phase I and pharmacologic study of oral (PEG-1000) 9-aminocamptothecin in adult patients with solid tumors. de Jonge, M.J., Punt, C.J., Gelderblom, A.H., Loos, W.J., van Beurden, V., Planting, A.S., van der Burg, M.E., van Maanen, L.W., Dallaire, B.K., Verweij, J., Wagener, D.J., Sparreboom, A. J. Clin. Oncol. (1999) [Pubmed]
  17. Short-chain glucose polymer and anthracene-9-carboxylic acid inhibit water and electrolyte secretion induced by dibutyryl cyclic AMP in the small intestine. Rabbani, G.H., Lu, R.B., Horvath, K., Lebenthal, E. Gastroenterology (1991) [Pubmed]
  18. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis. Mayet, W.J., Csernok, E., Szymkowiak, C., Gross, W.L., Meyer zum Büschenfelde, K.H. Blood (1993) [Pubmed]
  19. Response of Wegener's granulomatosis to anti-CD20 chimeric monoclonal antibody therapy. Specks, U., Fervenza, F.C., McDonald, T.J., Hogan, M.C. Arthritis Rheum. (2001) [Pubmed]
  20. Bone marrow-derived cells are sufficient and necessary targets to mediate glomerulonephritis and vasculitis induced by anti-myeloperoxidase antibodies. Schreiber, A., Xiao, H., Falk, R.J., Jennette, J.C. J. Am. Soc. Nephrol. (2006) [Pubmed]
  21. Properties of a protein kinase C-activated chloride current in guinea pig ventricular myocytes. Walsh, K.B., Long, K.J. Circ. Res. (1994) [Pubmed]
  22. NO/cGMP pathway activation and membrane potential depolarization in pig ciliary epithelium. Fleischhauer, J.C., Bény, J.L., Flammer, J., Haefliger, I.O. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  23. Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis. Schwarting, A., Hagen, D., Odenthal, M., Brockmann, H., Dienes, H.P., Wandel, E., Rumpelt, H.J., Zum Büschenfelde, K.H., Galle, P.R., Mayet, W. Kidney Int. (2000) [Pubmed]
  24. Activation of potassium currents by inhibitors of calcium-activated chloride conductance in rabbit portal vein smooth muscle cells. Toma, C., Greenwood, I.A., Helliwell, R.M., Large, W.A. Br. J. Pharmacol. (1996) [Pubmed]
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  26. Fever-Like Temperatures Affect Neutrophil NF-{kappa}B Signaling, Apoptosis, and ANCA-Antigen Expression. Kettritz, R., Choi, M., Salanova, B., Wellner, M., Rolle, S., Luft, F.C. J. Am. Soc. Nephrol. (2006) [Pubmed]
  27. Agonist-stimulated Cl- efflux from human neutrophils. A common phenomenon during neutrophil activation. Shimizu, Y., Daniels, R.H., Elmore, M.A., Finnen, M.J., Hill, M.E., Lackie, J.M. Biochem. Pharmacol. (1993) [Pubmed]
  28. Serum levels of interleukins 8 and 10, interferon gamma, granulocyte-macrophage colony stimulating factor and soluble CD23 in patients with primary sclerosing cholangitis. Bansal, A.S., Thomson, A., Steadman, C., Le Gros, G., Hogan, P.G., Kerlin, P., Lynch, S., Strong, R. Autoimmunity (1997) [Pubmed]
  29. Interaction of transforming growth factor beta (TGF beta) with proteinase 3. Kekow, J., Csernok, E., Szymkowiak, C., Gross, W.L. Adv. Exp. Med. Biol. (1997) [Pubmed]
  30. Expression of somatostatin receptors in inflammatory lesions and diagnostic value of somatostatin receptor scintigraphy in patients with ANCA-associated small vessel vasculitis. Neumann, I., Mirzaei, S., Birck, R., Osinger, K., Waldherr, R., Köhn, H.D., Meisl, F.T., Mirszaei, S. Rheumatology (Oxford, England) (2004) [Pubmed]
  31. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Landers, C.J., Cohavy, O., Misra, R., Yang, H., Lin, Y.C., Braun, J., Targan, S.R. Gastroenterology (2002) [Pubmed]
  32. Pharmacokinetics of mycophenolate mofetil in patients with autoimmune diseases compared renal transplant recipients. Neumann, I., Haidinger, M., Jäger, H., Grützmacher, H., Griesmacher, A., Müller, M.M., Bayer, P.M., Meisl, F.T. J. Am. Soc. Nephrol. (2003) [Pubmed]
  33. Autoantibodies to neutrophil cytoplasmic antigens in systemic vasculitis have the same target specificity. Harrison, D.J., Kharbanda, R. J. Pathol. (1989) [Pubmed]
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