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Chemical Compound Review:

Desglugastrin 4-[[(1S)-1-[[(1S)-1-[[(1S)-1- [[(1S)-1...

Synonyms: Desglugastrina, Desglugastrine, CHEMBL2106407, AC1Q5IPX, AR-1J9008, ...

Edwards, B.F. et al., Tanaka, T. et al., Bickel, M. et al.

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Disease relevance of Desglugastrin

In view of the trophic action of gastrointestinal hormones on the exocrine pancreas, the effects of secretin, octapeptide of cholecystokinin (CCK-8), and desglugastrin on the growth of hamster pancreatic well differentiated adenocarcinoma were investigated in vitro [1].

High impact information on Desglugastrin

In conscious pylorus-ligated rats, HWA 285 (10-100 mg/kg i.p.) showed a dose-dependent inhibition on basal and desglugastrin- and 2-deoxy-D-glucose (2-DG)-stimulated gastric acid secretion [2].

Associations of Desglugastrin with other chemical compounds

The antagonists inhibited gastric acid secretion in the rat induced by all stimuli tested, carbachol, desglugastrin and histamine [3].

References

The effect of gastrointestinal hormones on the incorporation of tritiated thymidine in the pancreatic adenocarcinoma cell line (WD PaCa). Edwards, B.F., Redding, T.W., Schally, A.V. Int. J. Pancreatol. (1989) [Pubmed]
Effects of the novel anti-ulcer agent 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats. Tanaka, T., Bickel, M., Herling, A.W., Sakurai, M., Goto, M., Hayashi, S. Arzneimittel-Forschung. (1989) [Pubmed]
Antisecretory effects of two new histamine H2-receptor antagonists. Bickel, M., Herling, A.W., Rising, T.J., Wirth, K. Arzneimittel-Forschung. (1986) [Pubmed]

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