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Gene Review

SCT  -  secretin

Homo sapiens

Synonyms: Secretin
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Disease relevance of SCT


Psychiatry related information on SCT

  • This reduced-intensity conditioning regimen is the basis of non-myeloablative allo-SCT (also referred to as mini SCT), a new treatment modality that relies more heavily on the antitumour effect exerted by the donor cells than on the antitumour effect of the conditioning therapy [5].
  • The patients did not have a normal increase in duodenal spike or motor activity after intestinal distension, but duodenal activity increased after stimulation with intravenous secretin [6].
  • Fifty-six subjects with autistic disorder received either a secretin or placebo infusion at baseline and the other substance at week 4 [7].
  • By evaluating the pattern of time-response curves obtained from serial T2-weighted EPI after secretin injection, pancreatic exocrine function may be directly assessed at the level of the head, body, and tail [8].
  • The plasma concentration of secretin was measured during a 5-day military training course comprising prolonged physical exercise (35% of max O2 uptake), severe caloric deficiency (approx. 35700 kJ/24 h) and sleep deprivation (only 2 h of sleep as a total during 5 days) [9].

High impact information on SCT


Chemical compound and disease context of SCT


Biological context of SCT


Anatomical context of SCT


Associations of SCT with chemical compounds

  • The expressions of secretin in PANC-1 and HepG2 cells were subsequently found to be significantly activated by a demethylation agent, 5'-Aza-2' deoxycytidine [1].
  • Dose-dependent increases in HCO(3)(-) secretion were observed in response to stimulation of both secretin and VPAC receptors [23].
  • Results of this study demonstrated that secretin self-assembles to form micelles in HEPES buffer at 25 degrees C above approximately 0.4 microM [24].
  • This variant with an in-frame deletion was shown to be synthesized and to traffic to the cell surface normally, where it could neither bind secretin nor mediate a secretin-stimulated adenosine 3',5'-cyclic monophosphate response [25].
  • The ability of 1 microM, but not 1 nM, secretin to stimulate intracellular cyclic AMP generation in these cells was consistent with VIP-1 receptor expression [26].

Physical interactions of SCT

  • Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors [27].
  • Mutational analysis of a proximal enhancer in the secretin gene identified several cis-acting elements in addition to the E-box binding site for BETA2 [28].

Regulatory relationships of SCT


Other interactions of SCT


Analytical, diagnostic and therapeutic context of SCT


  1. Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element. Lee, L.T., Tan-Un, K.C., Pang, R.T., Lam, D.T., Chow, B.K. Mol. Endocrinol. (2004) [Pubmed]
  2. Molecular cloning and expression of a human secretin receptor. Patel, D.R., Kong, Y., Sreedharan, S.P. Mol. Pharmacol. (1995) [Pubmed]
  3. Secretin receptors in the human liver: Expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. K??rner, M., Hayes, G.M., Rehmann, R., Zimmermann, A., Scholz, A., Wiedenmann, B., Miller, L.J., Reubi, J.C. J. Hepatol. (2006) [Pubmed]
  4. Similar involvement of VIP receptor type I and type II in lymphocyte chemotaxis. Schratzberger, P., Geiseler, A., Dunzendorfer, S., Reinisch, N., Kähler, C.M., Wiedermann, C.J. J. Neuroimmunol. (1998) [Pubmed]
  5. Advantages and limitations of (non-)myeloablative allogeneic stem cell transplantation. Huugen, D., Schouten, H.C., Bos, G.M. The Netherlands journal of medicine. (2002) [Pubmed]
  6. Gastrointestinal myoelectrical activity in idiopathic intestinal pseudo-obstruction. Sullivan, M.A., Snape, W.J., Matarazzo, S.A., Petrokubi, R.J., Jeffries, G., Cohen, S. N. Engl. J. Med. (1977) [Pubmed]
  7. Multisite, double-blind, placebo-controlled trial of porcine secretin in autism. Owley, T., McMahon, W., Cook, E.H., Laulhere, T., South, M., Mays, L.Z., Shernoff, E.S., Lainhart, J., Modahl, C.B., Corsello, C., Ozonoff, S., Risi, S., Lord, C., Leventhal, B.L., Filipek, P.A. Journal of the American Academy of Child and Adolescent Psychiatry. (2001) [Pubmed]
  8. Functional assessment of pancreatic parenchyma after secretin administration using serial T2-weighted echo-planar magnetic resonance imaging. Masui, T., Katayama, M., Kobayashi, S., Ito, T., Kabasawa, H., Nozaki, A., Sakahara, H. Journal of magnetic resonance imaging : JMRI. (2001) [Pubmed]
  9. Secretin--a new stress hormone? Oektedalen, O., Opstad, P.K., Schaffalitzky de Muckadell, O.B. Regul. Pept. (1982) [Pubmed]
  10. Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. Sandler, A.D., Sutton, K.A., DeWeese, J., Girardi, M.A., Sheppard, V., Bodfish, J.W. N. Engl. J. Med. (1999) [Pubmed]
  11. The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Mutoh, H., Naya, F.J., Tsai, M.J., Leiter, A.B. Genes Dev. (1998) [Pubmed]
  12. A chromosomally integrated bacteriophage in invasive meningococci. Bille, E., Zahar, J.R., Perrin, A., Morelle, S., Kriz, P., Jolley, K.A., Maiden, M.C., Dervin, C., Nassif, X., Tinsley, C.R. J. Exp. Med. (2005) [Pubmed]
  13. Endothelin-1 is synthesized and inhibits cyclic adenosine monophosphate- dependent anion secretion by an autocrine/paracrine mechanism in gallbladder epithelial cells. Fouassier, L., Chinet, T., Robert, B., Carayon, A., Balladur, P., Mergey, M., Paul, A., Poupon, R., Capeau, J., Barbu, V., Housset, C. J. Clin. Invest. (1998) [Pubmed]
  14. Failure of secretin to stimulate gastrin release and adenylate cyclase activity in gastrinoma in vitro. Ellison, E.C., O'Dorisio, M.S., O'Dorisio, T., Sparks, J., Vasallo, L., Woltering, E.A. Surgery (1984) [Pubmed]
  15. Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology. Christophe, J., Waelbroeck, M., Chatelain, P., Robberecht, P. Peptides (1984) [Pubmed]
  16. Successful treatment of AL amyloidosis with high-dose melphalan and autologous stem cell transplantation in patients over age 65. Seldin, D.C., Anderson, J.J., Skinner, M., Malek, K., Wright, D.G., Quillen, K., Finn, K., Oran, B., Sanchorawala, V. Blood (2006) [Pubmed]
  17. Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation. Spaepen, K., Stroobants, S., Dupont, P., Vandenberghe, P., Maertens, J., Bormans, G., Thomas, J., Balzarini, J., De Wolf-Peeters, C., Mortelmans, L., Verhoef, G. Blood (2003) [Pubmed]
  18. Combined surgery and cidofovir is an effective treatment for genital warts in HIV-infected patients. Orlando, G., Fasolo, M.M., Beretta, R., Merli, S., Cargnel, A. AIDS (2002) [Pubmed]
  19. The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism. Yamagata, T., Aradhya, S., Mori, M., Inoue, K., Momoi, M.Y., Nelson, D.L. Genomics (2002) [Pubmed]
  20. Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. Whitmore, T.E., Holloway, J.L., Lofton-Day, C.E., Maurer, M.F., Chen, L., Quinton, T.J., Vincent, J.B., Scherer, S.W., Lok, S. Cytogenet. Cell Genet. (2000) [Pubmed]
  21. Human VPAC1 receptor selectivity filter. Identification of a critical domain for restricting secretin binding. Du, K., Couvineau, A., Rouyer-Fessard, C., Nicole, P., Laburthe, M. J. Biol. Chem. (2002) [Pubmed]
  22. Review article: transcriptional events controlling the terminal differentiation of intestinal endocrine cells. Mutoh, H., Ratineau, C., Ray, S., Leiter, A.B. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  23. Vectorial bicarbonate transport by capan-1 cells: a model for human pancreatic ductal secretion. Szucs, A., Demeter, I., Burghardt, B., Ovari, G., Case, M., Steward, M., Varga, G. Cell. Physiol. Biochem. (2006) [Pubmed]
  24. Secretin self-assembles and interacts spontaneously with phospholipids in vitro. Gandhi, S., Rubinstein, I., Tsueshita, T., Onyuksel, H. Peptides (2002) [Pubmed]
  25. Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma. Ding, W.Q., Kuntz, S., Böhmig, M., Wiedenmann, B., Miller, L.J. Gastroenterology (2002) [Pubmed]
  26. Vasoactive intestinal peptide (VIP) stimulates in vitro growth of VIP-1 receptor-bearing human pancreatic adenocarcinoma-derived cells. Jiang, S., Kopras, E., McMichael, M., Bell, R.H., Ulrich, C.D. Cancer Res. (1997) [Pubmed]
  27. Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors. Harikumar, K.G., Morfis, M.M., Lisenbee, C.S., Sexton, P.M., Miller, L.J. Mol. Pharmacol. (2006) [Pubmed]
  28. Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Ray, S.K., Nishitani, J., Petry, M.W., Fessing, M.Y., Leiter, A.B. Mol. Cell. Biol. (2003) [Pubmed]
  29. Hormonal regulation of bicarbonate secretion in the biliary epithelium. Alvaro, D., Gigliozzi, A., Fraioli, F., Romeo, R., Papa, E., Delle Monache, M., Capocaccia, L. The Yale journal of biology and medicine. (1997) [Pubmed]
  30. Atrial natriuretic factor negatively modulates secretin intracellular signaling in the exocrine pancreas. Sabbatini, M.E., Vatta, M.S., Davio, C.A., Bianciotti, L.G. Am. J. Physiol. Gastrointest. Liver Physiol. (2007) [Pubmed]
  31. Effects of human corticotropin releasing factor (CRF) on gastric and pancreatic secretion in vivo and in vitro. Konturek, S.J., Yanaihara, C., Yanaihara, N., Mochizuki, T., Bilski, J., Dembinski, A., Jaworek, J. Peptides (1987) [Pubmed]
  32. Expression and spatial distribution of secretin and secretin receptor in human cerebellum. Lee, S.M., Yung, W.H., Chen, L., Chow, B.K. Neuroreport (2005) [Pubmed]
  33. Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor. Chow, B.K. Receptors & signal transduction. (1997) [Pubmed]
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