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Chemical Compound Review

Carbastat     2-aminocarbonyloxyethyl- trimethyl-azanium...

Synonyms: Jestryl, Miostat, carbachol, Carbyl, Doryl, ...
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Disease relevance of Carbamylcholine

 

Psychiatry related information on Carbamylcholine

 

High impact information on Carbamylcholine

  • In COS-7 cells, cotransfection of hm1 or hm2 receptors with Ras-GRF conferred carbachol-dependent increases in exchange-factor activity, whereas cotransfection with G-protein beta gamma subunits caused a constitutive activation that was sensitive to PP1 [11].
  • In NIH-3T3 cells expressing subtype 1 human muscarinic receptors (hm1), the agonist carbachol selectively increased the specific activity and phosphorylation state of epitope-tagged Ras-GRF [11].
  • DNA synthesis is strongly activated by carbachol in those brain-derived cell lines and transfected CHO cells that express mAChR subtypes which activate PI hydrolysis efficiently, and poorly activated in cells expressing mAChR subtypes which only weakly activate PI hydrolysis [2].
  • As PI hydrolysis is thought to be important in the regulation of cell proliferation, we investigated whether cellular DNA synthesis can be induced by carbachol [2].
  • Our results show that carbachol stimulates DNA synthesis via muscarinic acetylcholine receptors (mAChRs), in primary astrocytes derived from perinatal rat brain, in an age-dependent fashion [2].
 

Chemical compound and disease context of Carbamylcholine

 

Biological context of Carbamylcholine

 

Anatomical context of Carbamylcholine

 

Associations of Carbamylcholine with other chemical compounds

  • However, we report here that after inhibiting AChE in a cholinergic synapse in Aplysia, we found an increase not only in postsynaptic responses to presynaptic stimulation and to ionophoretic application of ACh on postsynaptic receptors, but also to ionophoretic application of carbachol [24].
  • Cl(-) permeability is increased by several secretagogues, some of which, such as theophylline and choleragen, increase intracellular cyclic AMP concentration, and others, such as A23187, the Ca(2+) ionophore, or carbachol, do not(8) [25].
  • The muscarinic agonist carbachol both inhibited adenylyl cyclase and stimulated phosphoinositide hydrolysis [26].
  • The responses of isolated guinea pig tracheal spirals and parenchymal strips to histamine and carbachol were compared [27].
  • Indeed, steady-state labeling of these phospholipids with [3H]inositol confirmed this idea since only carbachol caused detectable inositol phospholipid hydrolysis [28].
 

Gene context of Carbamylcholine

 

Analytical, diagnostic and therapeutic context of Carbamylcholine

References

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  19. Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis. Powers, R.E., Saluja, A.K., Houlihan, M.J., Steer, M.L. J. Clin. Invest. (1986) [Pubmed]
  20. Concanavalin A amplifies both beta-adrenergic and muscarinic cholinergic receptor-adenylate cyclase-linked pathways in cardiac myocytes. Rocha-Singh, K.J., Hines, D.K., Honbo, N.Y., Karliner, J.S. J. Clin. Invest. (1991) [Pubmed]
  21. Maturational regulation of inositol 1,4,5-trisphosphate metabolism in rabbit airway smooth muscle. Rosenberg, S.M., Berry, G.T., Yandrasitz, J.R., Grunstein, M.M. J. Clin. Invest. (1991) [Pubmed]
  22. Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro. Mann, E.O., Suckling, J.M., Hajos, N., Greenfield, S.A., Paulsen, O. Neuron (2005) [Pubmed]
  23. Regulated Cl transport, K and Cl permeability, and exocytosis in T84 cells. Huflejt, M.E., Blum, R.A., Miller, S.G., Moore, H.P., Machen, T.E. J. Clin. Invest. (1994) [Pubmed]
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  28. Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets. Peter-Riesch, B., Fathi, M., Schlegel, W., Wollheim, C.B. J. Clin. Invest. (1988) [Pubmed]
  29. Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. McCole, D.F., Rogler, G., Varki, N., Barrett, K.E. Gastroenterology (2005) [Pubmed]
  30. Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Madsen, K.L., Lewis, S.A., Tavernini, M.M., Hibbard, J., Fedorak, R.N. Gastroenterology (1997) [Pubmed]
  31. Involvement of the anion exchanger SLC26A6 in prostaglandin E2- but not forskolin-stimulated duodenal HCO3- secretion. Tuo, B., Riederer, B., Wang, Z., Colledge, W.H., Soleimani, M., Seidler, U. Gastroenterology (2006) [Pubmed]
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