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Chemical Compound Review

Carbastat     2-aminocarbonyloxyethyl- trimethyl-azanium...

Synonyms: Jestryl, Miostat, carbachol, Carbyl, Doryl, ...
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Disease relevance of Carbamylcholine


Psychiatry related information on Carbamylcholine


High impact information on Carbamylcholine

  • In COS-7 cells, cotransfection of hm1 or hm2 receptors with Ras-GRF conferred carbachol-dependent increases in exchange-factor activity, whereas cotransfection with G-protein beta gamma subunits caused a constitutive activation that was sensitive to PP1 [11].
  • In NIH-3T3 cells expressing subtype 1 human muscarinic receptors (hm1), the agonist carbachol selectively increased the specific activity and phosphorylation state of epitope-tagged Ras-GRF [11].
  • DNA synthesis is strongly activated by carbachol in those brain-derived cell lines and transfected CHO cells that express mAChR subtypes which activate PI hydrolysis efficiently, and poorly activated in cells expressing mAChR subtypes which only weakly activate PI hydrolysis [2].
  • As PI hydrolysis is thought to be important in the regulation of cell proliferation, we investigated whether cellular DNA synthesis can be induced by carbachol [2].
  • Our results show that carbachol stimulates DNA synthesis via muscarinic acetylcholine receptors (mAChRs), in primary astrocytes derived from perinatal rat brain, in an age-dependent fashion [2].

Chemical compound and disease context of Carbamylcholine


Biological context of Carbamylcholine


Anatomical context of Carbamylcholine


Associations of Carbamylcholine with other chemical compounds

  • However, we report here that after inhibiting AChE in a cholinergic synapse in Aplysia, we found an increase not only in postsynaptic responses to presynaptic stimulation and to ionophoretic application of ACh on postsynaptic receptors, but also to ionophoretic application of carbachol [24].
  • Cl(-) permeability is increased by several secretagogues, some of which, such as theophylline and choleragen, increase intracellular cyclic AMP concentration, and others, such as A23187, the Ca(2+) ionophore, or carbachol, do not(8) [25].
  • The muscarinic agonist carbachol both inhibited adenylyl cyclase and stimulated phosphoinositide hydrolysis [26].
  • The responses of isolated guinea pig tracheal spirals and parenchymal strips to histamine and carbachol were compared [27].
  • Indeed, steady-state labeling of these phospholipids with [3H]inositol confirmed this idea since only carbachol caused detectable inositol phospholipid hydrolysis [28].

Gene context of Carbamylcholine


Analytical, diagnostic and therapeutic context of Carbamylcholine


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  19. Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis. Powers, R.E., Saluja, A.K., Houlihan, M.J., Steer, M.L. J. Clin. Invest. (1986) [Pubmed]
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