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Chemical Compound Review

Stakane     2-[4-[3-(trifluoromethyl) phenyl]piperazin...

Synonyms: Stakan, Antrafenine, Antrafenino, Antrafeninum, CHEMBL345524, ...
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Disease relevance of Stakan


High impact information on Stakan


Biological context of Stakan


Analytical, diagnostic and therapeutic context of Stakan

  • Compound 45, 2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl 2-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoate (antrafenine), showed marked analgesic activity, long duration of action, and excellent tolerance in pharmacological and toxicological studies, as well as in clinical trials [5].
  • Antrafenine was measured by high-performance liquid chromatography using a Spherisorb 5-micrometer ODS column with acetonitrile-0.1 M sodium acetate as the mobile phase [6].


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