Disease relevance of Soft Tissue Injuries

• METHODS: Anesthetized (fentanyl) mongrel pigs were sham injured or fluid resuscitated from soft tissue injury +35% hemorrhage [1].
• Nabumetone, a new nonsteroidal anti-inflammatory agent, has been evaluated for the treatment of skin and soft tissue injury, including sports injury, in clinical trials involving nearly 1,000 patients [2].
• The disease indications comprised osteoarthritis (69.8%), soft-tissue rheumatism (11.3%), rheumatoid arthritis (9.9%) and soft tissue injuries (7.7%) [3].
• Due to their consistent presence at the tissue level, high systemic concentrations of IL-6 and IL-8 in patients blood, seen after pulmonary trauma, long bone fractures, or soft tissue injury, may be interpreted as an overspill of local trauma mediators [4].
• Thus, the same pattern of muscular reaction was found in patients with rheumatoid arthritis as in patients with soft-tissue injuries of the neck (e.g., "whiplash injury") [5].

High impact information on Soft Tissue Injuries

• Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study [6].
• The efficacy of nabumetone in the treatment of soft tissue injury has been demonstrated to be similar to that of soluble aspirin, ibuprofen, and naproxen [2].
• The clinical efficacy of nabumetone has also been evaluated in patients with ankylosing spondylitis, soft tissue injuries and juvenile RA [7].
• CONCLUSION: A high prevalence of occult pelvic fracture and soft-tissue injury may be identified with MR studies designed to evaluate occult hip fracture when large-field-of-view T1-weighted coronal sequences are combined with T2-weighted or STIR sequences [8].
• Capsaicin has been used extensively as an experimental tool and in traditional and proprietary topical medications for acute soft tissue injuries [9].

Chemical compound and disease context of Soft Tissue Injuries

• Nabumetone in the treatment of skin and soft tissue injury [2].
• Unlike phenytoin, it does not require propylene glycol and high alkalinity for solubility and therefore does not produce soft-tissue injury after parenteral administration [10].
• Soft-tissue injury caused by antineoplastic drugs is inhibited by topical dimethyl sulphoxide and alpha tocopherol [11].
• Treatment of mild to moderate pain of acute soft tissue injury: diflunisal vs acetaminophen with codeine [12].
• In conclusion, ketoprofen gel may offer benefits over established therapies for the treatment of acute soft-tissue injury [13].

Biological context of Soft Tissue Injuries

• Thus, the objective of this study was to quantitatively analyze the acute effects of NAC on skeletal muscle microcirculation and leukocyte-endothelial cell interaction following severe standardized closed soft tissue injury (CSTI) [14].
• Comparison of ketoprofen, piroxicam, and diclofenac gels in the treatment of acute soft-tissue injury in general practice. General Practice Study Group [13].
• OBJECTIVE: To review the pharmacology, pharmacokinetic disposition, dosage recommendations, adverse effects, drug interactions, and efficacy of nabumetone in patients with selected rheumatic disorders and soft-tissue injuries [15].
• Balanced salt solution volume diuresis supplemented with furosemide as necessary appears to be safe and effective in preventing AIRF in soft tissue injuries sustained in beatings [16].
• METHODS: Male Sprague-Dawley rats (350-400 g) underwent a 5-cm midline laparotomy (i.e., soft tissue injury), were bled to a mean arterial pressure of 35 mmHg and maintained for approximately 90 min, and then resuscitated with Ringer's lactate (4x the shed blood volume) over 60 min [17].

Anatomical context of Soft Tissue Injuries

• Injuries at the vertebral levels T8, T9, and T10 represent a gray zone; and, depending on adjacent soft tissue injury, in these patients an upper or lower motor neuron bladder dysfunction developed [18].
• LPS is the most prominent form of instability of the knee in patients complaining of "giving way" of the knee, and recovery from severe soft-tissue injury to the knee joint [19].

Gene context of Soft Tissue Injuries

• These results deserve further investigation to prove that selective COX-2 inhibitors improve performance and promote healing following closed soft-tissue injury [20].
• PURPOSE: To report three patients in whom focal epilepsy developed shortly after painful soft tissue injuries to their hands [21].
• In this model MGI 114 and doxorubicin were found to produce similar soft tissue injuries, but MGI 114-induced lesions tended to show a more rapid resolution [22].
• INTERVENTION: Male rats underwent midline laparotomy (ie, soft tissue injury) [23].
• BACKGROUND: Ice is applied following a soft-tissue injury on the basis of clinical information [24].

Analytical, diagnostic and therapeutic context of Soft Tissue Injuries

• Piroxicam 0.5% topical gel compared to placebo in the treatment of acute soft tissue injuries: a double-blind study comparing efficacy and safety [25].
• Phase III clinical trials in patients with non-articular rheumatism and traumatic painful soft tissue injuries showed that the topical ketoprofen patch was significantly more effective than placebo at reducing pain during daily activities and spontaneous pain after 7 days' treatment [26].
• Single blind study to evaluate the efficacy and safety of naproxen gel compared with diclophenac emulgel in the treatment of soft tissue injuries [27].

References