Disease relevance of Epiestriol

• The anti-inflammatory activity of 16-epiestriol was determined using a modified Winter's carrageenin rat paw edema model [1].

High impact information on Epiestriol

• In contrast to the suppressive effects of hydrocortisone, none of the 16-epiestriol concentrations inhibited concanavalin A-stimulated IFN-gamma production by spleen cells, as determined by ELISA [2].
• Flow cytometric analysis confirmed that 16-epiestriol did not alter the number of CD3+ T cells in the spleen [2].
• 16-Epiestriol does not conform to classical steroidal structure-activity relationship theory [1].

Chemical compound and disease context of Epiestriol

• In the anti-inflammatory study, 16-epiestriol was more than twice as effective as hydrocortisone, on an equimolar basis, in preventing edema [1].

Associations of Epiestriol with other chemical compounds

• Incubating spleen cells from untreated mice in concentrations of 16-epiestriol ranging from 1 mg/ml to 100 pg/ml did not alter profiles of IFN-gamma production, in contrast to the suppressive dose-response effects of hydrocortisone [2].

References