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Chemical Compound Review

Faridak     (E)-N-hydroxy-3-[4-[[2-(2- methyl-1H-indol...

Synonyms: Panobinostat, NVP-LBH-589, NVP-LBH589, PubChem19147, LBH-589, ...
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Disease relevance of Faridak


Associations of Faridak with other chemical compounds

  • HDACI LBH589 induced degradation of both Aurora A and B kinases through a proteasome-mediated pathway by targeting HDAC3 and HDAC6 [2].


  1. High efficacy of panobinostat towards human gastrointestinal stromal tumors in a xenograft mouse model. Floris, G., Debiec-Rychter, M., Sciot, R., Stefan, C., Fieuws, S., Machiels, K., Atadja, P., Wozniak, A., Faa, G., Schöffski, P. Clin. Cancer Res. (2009) [Pubmed]
  2. Dual degradation of aurora A and B kinases by the histone deacetylase inhibitor LBH589 induces G2-M arrest and apoptosis of renal cancer cells. Cha, T.L., Chuang, M.J., Wu, S.T., Sun, G.H., Chang, S.Y., Yu, D.S., Huang, S.M., Huan, S.K., Cheng, T.C., Chen, T.T., Fan, P.L., Hsiao, P.W. Clin. Cancer Res. (2009) [Pubmed]
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