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Chemical Compound Review:

CHEMBL566727 2-amino-4-oxo-1H-pteridine-6- carboxylic acid

Synonyms: SureCN893092, SureCN893094, AG-D-96713, AG-K-79193, BSPBio_003326, ...

Jamil Akhtar, M. et al., Hirakawa, K., Akhtar, M.J. et al., Rokos, H. et al., Soini, J. et al.

Hirakawa, Jamil Akhtar, Ataullah Khan, Ahmad,

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Disease relevance of Pterin-6-carboxylic acid

Studies on the degradation of pterine and pterine-6-carboxylic acid by Pseudomonas fluorescens UK-1 [1].

High impact information on Pterin-6-carboxylic acid

Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid [2].
The UV irradiated aqueous solutions of folic acid at pH 2-10 degrade to give pterin-6-carboxylic acid and p-aminobenzoyl-L-glutamic acid under aerobic conditions [3].
The photolysis of folic acid shows that it is degraded to pterine-6-carboxylic acid and p-amino-benzoyl-L-glutamic acid [4].
Folic acid was decomposed by H(2)O(2) in the presence of Cu(II) into pterine-6-carboxylic acid, leading to strong fluorescence enhancement [5].

References

Studies on the degradation of pterine and pterine-6-carboxylic acid by Pseudomonas fluorescens UK-1. Soini, J., Backman, A. Acta Chem. Scand., B, Org. Chem. Biochem. (1975) [Pubmed]
Oxidative stress in vitiligo: photo-oxidation of pterins produces H(2)O(2) and pterin-6-carboxylic acid. Rokos, H., Beazley, W.D., Schallreuter, K.U. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Identification of photoproducts of folic acid and its degradation pathways in aqueous solution. Jamil Akhtar, M., Ataullah Khan, M., Ahmad, I. Journal of pharmaceutical and biomedical analysis. (2003) [Pubmed]
Photodegradation of folic acid in aqueous solution. Akhtar, M.J., Khan, M.A., Ahmad, I. Journal of pharmaceutical and biomedical analysis. (1999) [Pubmed]
Fluorometry of hydrogen peroxide using oxidative decomposition of folic acid. Hirakawa, K. Analytical and bioanalytical chemistry. (2006) [Pubmed]

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