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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

D-Valine     (2R)-2-amino-3-methyl-butanoic acid

Synonyms: R-Valine, D-valin, D-Val, D-VAL-OH, D-VALINE-OH, ...
 
 
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High impact information on valine

  • In leucine dehydrogenase, an enzyme belonging to the same superfamily, the equivalent residues are L40 and V294, which create a more hydrophobic specificity pocket and provide an explanation for their differential substrate specificity [1].
  • 3. Val-treated astrocytes presented the most dramatic morphological alterations [2].
  • 4. Furthermore, creatine attenuated the morphological alterations provoked by the BCAA, the protection being more pronounced for Val, suggesting that impairment of energy homeostasis is partially involved in BCAA cytotoxic action [2].

References

  1. Determinants of substrate specificity in the superfamily of amino acid dehydrogenases. Baker, P.J., Waugh, M.L., Wang, X.G., Stillman, T.J., Turnbull, A.P., Engel, P.C., Rice, D.W. Biochemistry (1997) [Pubmed]
  2. Morphological alterations and cell death provoked by the branched-chain alpha-amino acids accumulating in maple syrup urine disease in astrocytes from rat cerebral cortex. Funchal, C., Gottfried, C., de Almeida, L.M., dos Santos, A.Q., Wajner, M., Pessoa-Pureur, R. Cell. Mol. Neurobiol. (2005) [Pubmed]
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