The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

D-Valine     (2R)-2-amino-3-methyl-butanoic acid

Synonyms: R-Valine, D-valin, D-Val, D-VAL-OH, D-VALINE-OH, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on valine

  • In leucine dehydrogenase, an enzyme belonging to the same superfamily, the equivalent residues are L40 and V294, which create a more hydrophobic specificity pocket and provide an explanation for their differential substrate specificity [1].
  • 3. Val-treated astrocytes presented the most dramatic morphological alterations [2].
  • 4. Furthermore, creatine attenuated the morphological alterations provoked by the BCAA, the protection being more pronounced for Val, suggesting that impairment of energy homeostasis is partially involved in BCAA cytotoxic action [2].


  1. Determinants of substrate specificity in the superfamily of amino acid dehydrogenases. Baker, P.J., Waugh, M.L., Wang, X.G., Stillman, T.J., Turnbull, A.P., Engel, P.C., Rice, D.W. Biochemistry (1997) [Pubmed]
  2. Morphological alterations and cell death provoked by the branched-chain alpha-amino acids accumulating in maple syrup urine disease in astrocytes from rat cerebral cortex. Funchal, C., Gottfried, C., de Almeida, L.M., dos Santos, A.Q., Wajner, M., Pessoa-Pureur, R. Cell. Mol. Neurobiol. (2005) [Pubmed]
WikiGenes - Universities