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Chemical Compound Review:

Bazinaprina 3-(2-morpholin-4- ylethylamino)-6-phenyl...

Synonyms: Bazinaprine, Bazinaprinum, CHEMBL150365, SureCN499295, CHEBI:350790, ...

Kan, J.P. et al., Worms, P. et al.

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Disease relevance of SR 95191

SR 95191 did not antagonize 3-hydroxy-4-methyl-alpha-phenylethylamine-induced hyperthermia [1].

High impact information on SR 95191

In the present study, the interaction of SR 95191 with MAO-A and MAO-B activity was further examined in vivo and in vitro [2].
Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: evidence for selective and reversible inhibition of monoamine oxidase type A in vivo but not in vitro [2].
In vitro, the inhibition of brain MAO-A, but not MAO-B, by SR 95191 was time dependent, with a 19-fold decrease in the IC50 values being observed over a 30-min incubation period (140 to 7.5 microM) [2].

Analytical, diagnostic and therapeutic context of SR 95191

In rodents, SR 95191 [3-(2-morpholinoethylamino)-4-cyano-6-phenylpyridazine] has been shown to be active in animal models of depression [2].

References

SR 95191, a selective inhibitor of type A monoamine oxidase with dopaminergic properties. I. Psychopharmacological profile in rodents. Worms, P., Kan, J.P., Wermuth, C.G., Roncucci, R., Bizière, K. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
Monoamine oxidase-inhibiting properties of SR 95191, a new pyridazine derivative, in the rat: evidence for selective and reversible inhibition of monoamine oxidase type A in vivo but not in vitro. Kan, J.P., Steinberg, R., Leclercq, J., Worms, P., Biziere, K. J. Neurochem. (1988) [Pubmed]

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