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Gene Review

Maob  -  monoamine oxidase B

Rattus norvegicus

Synonyms: MAO-B, Monoamine oxidase type B
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Disease relevance of Maob


Psychiatry related information on Maob


High impact information on Maob


Chemical compound and disease context of Maob


Biological context of Maob


Anatomical context of Maob


Associations of Maob with chemical compounds

  • Possible mechanisms for the release-enhancing effect of the MAO-B inhibitors include elevation in levels of endogenous beta-phenylethylamine, or an inhibition of DA reuptake, which develops only on chronic administration, because both deprenyl and TVP-1012 have only very weak effects on amine uptake in acute experiments [21].
  • Clorgyline inhibited MAO-A by 95%, with 30% inhibition of MAO-B [21].
  • Acute inhibition of monoamine oxidase B (MAO-B) in the rat does not affect striatal dopamine (DA) metabolism, but chronic MAO-B inhibition with deprenyl has been reported to increase the release of striatal DA, as shown using in vitro techniques [21].
  • Chronic treatment with the MAO-B inhibitors reduced striatal MAO-B activity by 90%, with 15% (TVP-1012) or 40% (deprenyl) inhibition of MAO-A [21].
  • Thus, while most of the condensed pyridazines were reversible inhibitors of MAO-B with little or no MAO-A effects, the pyrimidine derivatives proved to be reversible and selective MAO-A inhibitors [16].

Physical interactions of Maob

  • A relatively high density of [3H]RO41-1049 binding to MAO-A enzyme was present in all regions of the rat kidney (160-210 fmol/mg) compared with a low density of [3H]RO19-6327 binding to MAO-B (< 25 fmol/mg) [22].

Regulatory relationships of Maob


Other interactions of Maob

  • A single mutation in which Phe-208 in MAO A was substituted by the corresponding residue of Ile in MAO B was sufficient to convert the A-type substrate selectivity, and the reverse was exactly the case [26].
  • By a double-labeling immunofluorescence method, it was shown that MAOB immunoreactivity was localized in almost all of histidine decarboxylase (HDC)-positive cells [27].

Analytical, diagnostic and therapeutic context of Maob


  1. Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease. Youdim, M.B., Tipton, K.F. Parkinsonism Relat. Disord. (2002) [Pubmed]
  2. MPTP-induced duodenal ulcers in rat. Prevention by reuptake blockers for serotonin and norepinephrine, but not dopamine. Keshavarzian, A., Wibowo, A., Gordon, J.H., Fields, J.Z. Gastroenterology (1990) [Pubmed]
  3. Monoamine oxidase in rat and bovine endocrine tissues. Lenzen, S., Freisinger-Treichel, M., Panten, U. J. Neurochem. (1987) [Pubmed]
  4. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. Löscher, W., Lehmann, H., Teschendorf, H.J., Traut, M., Gross, G. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  5. In vivo effect of MPTP on monoamine oxidase activity in mouse striatum. Melamed, E., Youdim, M.B., Rosenthal, J., Spanier, I., Uzzan, A., Globus, M. Brain Res. (1985) [Pubmed]
  6. The novel neuropsychotropic agent milacemide is a specific enzyme-activated inhibitor of brain monoamine oxidase B. Janssens de Varebeke, P., Pauwels, G., Buyse, C., David-Remacle, M., De Mey, J., Roba, J., Youdim, M.B. J. Neurochem. (1989) [Pubmed]
  7. Studies of selective and reversible monoamine oxidase inhibitors. Mann, J.J., Aarons, S.F., Frances, A.J., Brown, R.D. The Journal of clinical psychiatry. (1984) [Pubmed]
  8. Effect of rapid eye movement sleep deprivation on rat brain monoamine oxidases. Thakkar, M., Mallick, B.N. Neuroscience (1993) [Pubmed]
  9. The cholinergic neurotoxin ethylcholine mustard aziridinium (AF64A) induces an increase in MAO-B activity in the rat brain. Jossan, S.S., Hiraga, Y., Oreland, L. Brain Res. (1989) [Pubmed]
  10. Promoting effect and recovery activity from physical stress of the fruit of Morus alba. Hwang, K.H., Kim, Y.K. Biofactors (2004) [Pubmed]
  11. Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. Levitt, P., Pintar, J.E., Breakefield, X.O. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  12. Acute hydrocephalus upregulates monoamine oxidase mRNA in neonatal rat brain. Kuo, M.F., Wu, K.D., Wu, R.M., Tu, Y.K., Wang, H.S. Neuroreport (2004) [Pubmed]
  13. Evaluation of the toxicity of the dopaminergic neurotoxins MPTP and MPP+ in PC12 pheochromocytoma cells: binding and biological studies. Marongiu, M.E., Piccardi, M.P., Bernardi, F., Corsini, G.U., Del Zompo, M. Neurosci. Lett. (1988) [Pubmed]
  14. Monoamine oxidase B expression is selectively regulated by dexamethasone in cultured rat astrocytes. Carlo, P., Violani, E., Del Rio, M., Olasmaa, M., Santagati, S., Maggi, A., Picotti, G.B. Brain Res. (1996) [Pubmed]
  15. Differential effects of metal ions on type A and type B monoamine oxidase activities in rat brain and liver mitochondria. Leung, T.K., Lim, L., Lai, J.C. Metabolic brain disease. (1992) [Pubmed]
  16. Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships. Altomare, C., Cellamare, S., Summo, L., Catto, M., Carotti, A., Thull, U., Carrupt, P.A., Testa, B., Stoeckli-Evans, H. J. Med. Chem. (1998) [Pubmed]
  17. Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation. Abu-Raya, S., Blaugrund, E., Trembovler, V., Shilderman-Bloch, E., Shohami, E., Lazarovici, P. J. Neurosci. Res. (1999) [Pubmed]
  18. 1-Methyl-4-phenylpyridinium (MPP+) binds with high affinity to a beta-carboline binding site located on monoamine oxidase type A in rat brain. May, T. Neurosci. Lett. (1993) [Pubmed]
  19. The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver. Strolin Benedetti, M., Sanson, G., Bona, L., Gallina, M., Persiani, S., Tipton, K.F. J. Neural Transm. Suppl. (1998) [Pubmed]
  20. Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B. Arai, R., Karasawa, N., Kurokawa, K., Kanai, H., Horiike, K., Ito, A. Neuroscience (2002) [Pubmed]
  21. Effect of long-term treatment with selective monoamine oxidase A and B inhibitors on dopamine release from rat striatum in vivo. Lamensdorf, I., Youdim, M.B., Finberg, J.P. J. Neurochem. (1996) [Pubmed]
  22. [3H]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [3H]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney. King, P.R., Suzuki, S., Hosseini, A.R., Iakovidis, D., Nero, T.L., Jackman, G.P., Louis, W.J., Gundlach, A.L. J. Auton. Nerv. Syst. (1998) [Pubmed]
  23. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors. Mazouz, F., Gueddari, S., Burstein, C., Mansuy, D., Milcent, R. J. Med. Chem. (1993) [Pubmed]
  24. Specific irreversible monoamine oxidase B inhibitors stimulate gene expression of aromatic L-amino acid decarboxylase in PC12 cells. Li, X.M., Juorio, A.V., Paterson, I.A., Zhu, M.Y., Boulton, A.A. J. Neurochem. (1992) [Pubmed]
  25. Chronic selegiline administration transiently decreases tyrosine hydroxylase activity and mRNA in the rat nigrostriatal pathway. Vrana, S.L., Azzaro, A.J., Vrana, K.E. Mol. Pharmacol. (1992) [Pubmed]
  26. A key amino acid responsible for substrate selectivity of monoamine oxidase A and B. Tsugeno, Y., Ito, A. J. Biol. Chem. (1997) [Pubmed]
  27. Immunocytochemical localization of monoamine oxidase type B in enterochromaffin-like cells of rat oxyntic mucosa. Okauchi, H., Nakajima, S., Tani, T., Ito, A., Arai, R. Histochem. Cell Biol. (2004) [Pubmed]
  28. Presence of monoamine oxidase type B protein but absence of associated enzyme activity in neurons within the inferior olive nucleus of the rat. Kouzaki, H., Suzuki, M., Shimizu, T., Aimi, Y., Ito, A., Arai, R. Brain Res. (2005) [Pubmed]
  29. Molecular cloning of a cDNA for rat liver monoamine oxidase B. Ito, A., Kuwahara, T., Inadome, S., Sagara, Y. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  30. Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex. Guimarães, J.T., Vindis, C., Soares-da-Silva, P., Parini, A. Life Sci. (2003) [Pubmed]
  31. Immunohistochemical localization of monoamine oxidase type B in the taste bud of the rat. Xu, Y., Ito, A., Arai, R. Neurotoxicology (2004) [Pubmed]
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