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Chemical Compound Review:

Humulone (6S)-3,5,6-trihydroxy-2-(3- methylbutanoyl)...

Synonyms: Humolon, Humulon, n-humulone, alpha-Humulon, CHEMBL463491, ...

Yamamoto, K. et al., Lee, J.C. et al., Yasukawa, K. et al.

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Disease relevance of Humulone

Humulon isolated from hop extract for beer brewing was reported previously as an inhibitor of bone resorption [Tobe, H. et al. (1997) Biosci. Biotech. Biochem. 61, 158-159] [1].
Furthermore, humulon inhibited arachidonic acid-induced inflammatory ear edema in mice [2].

High impact information on Humulone

These results showed that humulon suppressed cyclooxygenase-2 induction at the step of transcription [1].
Reporter gene experiments suggested that humulon blocked the cyclooxygenase-2 expression mediated by NFkappaB and NF-IL6, but the intracellular glucocorticoid receptor was not involved [1].

Gene context of Humulone

Taken together, humulone suppressed TPA-induced activation of NF-kappaB and AP-1 and subsequent expression of COX-2 by blocking upstream kinases IKK and JNK, respectively, which may account for its antitumor-promoting effects on mouse skin carcinogenesis [3].

References

Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. Yamamoto, K., Wang, J., Yamamoto, S., Tobe, H. FEBS Lett. (2000) [Pubmed]
Humulon, a bitter in the hop, inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Yasukawa, K., Takeuchi, M., Takido, M. Oncology (1995) [Pubmed]
Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Lee, J.C., Kundu, J.K., Hwang, D.M., Na, H.K., Surh, Y.J. Carcinogenesis (2007) [Pubmed]

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