Gene Review:
Nr3c1 - nuclear receptor subfamily 3, group C,...
Mus musculus
Synonyms:
GR, Glucocorticoid receptor, Grl, Grl-1, Grl1, ...
Liu,
Nakagawa,
Wang,
Sakurai,
Tripathi,
Lutfy,
Friedman,
Schmidt,
Schmidt,
Levine,
Oitzl,
van der Mark,
Müller,
Holsboer,
de Kloet,
Wei,
Lu,
Liu,
Schafer,
Shieh,
Burke,
Robinson,
Watson,
Seasholtz,
Akil,
Trune,
Kempton,
Gross,
Froger,
Palazzo,
Boni,
Hanoun,
Saurini,
Joubert,
Dutriez-Casteloot,
Enache,
Maccari,
Barden,
Cohen-Salmon,
Hamon,
Lanfumey,
Shao,
Egecioglu,
Weijdeg??rd,
Ljungstr??m,
Ling,
Fernandez-Rodriguez,
Billig,
- Loss of p16INK4a results in increased glucocorticoid receptor activity during fibrosarcoma development. Roca, R., Kypta, R.M., Vivanco, M.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Anthrax lethal factor represses glucocorticoid and progesterone receptor activity. Webster, J.I., Tonelli, L.H., Moayeri, M., Simons, S.S., Leppla, S.H., Sternberg, E.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The mouse mammary tumor virus promoter adopts distinct chromatin structures in human breast cancer cells with and without glucocorticoid receptor. Kinyamu, H.K., Fryer, C.J., Horwitz, K.B., Archer, T.K. J. Biol. Chem. (2000)
- T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Brewer, J.A., Khor, B., Vogt, S.K., Muglia, L.M., Fujiwara, H., Haegele, K.E., Sleckman, B.P., Muglia, L.J. Nat. Med. (2003)
- Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Wei, Q., Lu, X.Y., Liu, L., Schafer, G., Shieh, K.R., Burke, S., Robinson, T.E., Watson, S.J., Seasholtz, A.F., Akil, H. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Ontogeny of glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type-1 gene expression identifies potential critical periods of glucocorticoid susceptibility during development. Speirs, H.J., Seckl, J.R., Brown, R.W. J. Endocrinol. (2004)
- Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress. Froger, N., Palazzo, E., Boni, C., Hanoun, N., Saurini, F., Joubert, C., Dutriez-Casteloot, I., Enache, M., Maccari, S., Barden, N., Cohen-Salmon, C., Hamon, M., Lanfumey, L. J. Neurosci. (2004)
- Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Schmidt, M.V., Schmidt, M., Levine, S., Oitzl, M.S., van der Mark, M., Müller, M.B., Holsboer, F., de Kloet, E.R. Endocrinology (2005)
- Glucocorticoid receptor-dependent desensitization of 5-HT1A autoreceptors by sleep deprivation: studies in GR-i transgenic mice. Evrard, A., Barden, N., Hamon, M., Adrien, J. Sleep. (2006)
- Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R.K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M.G., Glass, C.K. Cell (2005)
- An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Kliewer, S.A., Moore, J.T., Wade, L., Staudinger, J.L., Watson, M.A., Jones, S.A., McKee, D.D., Oliver, B.B., Willson, T.M., Zetterström, R.H., Perlmann, T., Lehmann, J.M. Cell (1998)
- DNA binding of the glucocorticoid receptor is not essential for survival. Reichardt, H.M., Kaestner, K.H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., Schütz, G. Cell (1998)
- Reversible and persistent changes in chromatin structure accompany activation of a glucocorticoid-dependent enhancer element. Zaret, K.S., Yamamoto, K.R. Cell (1984)
- Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids. Francke, U., Gehring, U. Cell (1980)
- Transcriptional control of steroid-regulated apoptosis in murine thymoma cells. Chapman, M.S., Askew, D.J., Kuscuoglu, U., Miesfeld, R.L. Mol. Endocrinol. (1996)
- Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear. Trune, D.R., Kempton, J.B., Gross, N.D. Hear. Res. (2006)
- Potential mechanism for the effects of dexamethasone on growth of androgen-independent prostate cancer. Nishimura, K., Nonomura, N., Satoh, E., Harada, Y., Nakayama, M., Tokizane, T., Fukui, T., Ono, Y., Inoue, H., Shin, M., Tsujimoto, Y., Takayama, H., Aozasa, K., Okuyama, A. J. Natl. Cancer Inst. (2001)
- The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7. A comparison with the glucocorticoid receptor and the mouse and rat hepatic dioxin receptors. Cuthill, S., Poellinger, L., Gustafsson, J.A. J. Biol. Chem. (1987)
- Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Opherk, C., Tronche, F., Kellendonk, C., Kohlmüller, D., Schulze, A., Schmid, W., Schütz, G. Mol. Endocrinol. (2004)
- Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells. Cella, N., Groner, B., Hynes, N.E. Mol. Cell. Biol. (1998)
- The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development. Kingsley-Kallesen, M., Mukhopadhyay, S.S., Wyszomierski, S.L., Schanler, S., Schütz, G., Rosen, J.M. Mol. Endocrinol. (2002)
- Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Liu, Y., Nakagawa, Y., Wang, Y., Sakurai, R., Tripathi, P.V., Lutfy, K., Friedman, T.C. Diabetes (2005)
- Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line. Gaeggeler, H.P., Gonzalez-Rodriguez, E., Jaeger, N.F., Loffing-Cueni, D., Norregaard, R., Loffing, J., Horisberger, J.D., Rossier, B.C. J. Am. Soc. Nephrol. (2005)
- Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice. Gass, P., Kretz, O., Wolfer, D.P., Berger, S., Tronche, F., Reichardt, H.M., Kellendonk, C., Lipp, H.P., Schmid, W., Schütz, G. EMBO Rep. (2000)
- Interleukin 1alpha (IL-1alpha) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function. Wang, X., Wu, H., Miller, A.H. Mol. Psychiatry (2004)
- Progesterone Receptor Repression of Prolactin/Signal Transducer and Activator of Transcription 5-Mediated Transcription of the {beta}-Casein Gene in Mammary Epithelial Cells. Buser, A.C., Gass-Handel, E.K., Wyszomierski, S.L., Doppler, W., Leonhardt, S.A., Schaack, J., Rosen, J.M., Watkin, H., Anderson, S.M., Edwards, D.P. Mol. Endocrinol. (2007)
- Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors. Shao, R., Egecioglu, E., Weijdeg??rd, B., Ljungstr??m, K., Ling, C., Fernandez-Rodriguez, J., Billig, H. J. Endocrinol. (2006)
- Binding of androgen-receptor complexes to alpha 2u-globulin genes and to the long terminal repeat of mouse mammary tumor virus. Van Dijck, P., Winderickx, J., Heyns, W., Verhoeven, G. Mol. Cell. Endocrinol. (1989)
- Chronic glucocorticoid receptor activation impairs CREB transcriptional activity in clonal neurons. Föcking, M., Hölker, I., Trapp, T. Biochem. Biophys. Res. Commun. (2003)
- Regulation of hippocampal 5-HT1A receptor mRNA and binding in transgenic mice with a targeted disruption of the glucocorticoid receptor. Meijer, O.C., Cole, T.J., Schmid, W., Schütz, G., Joëls, M., De Kloet, E.R. Brain Res. Mol. Brain Res. (1997)
- Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway. Schmidt, P., Holsboer, F., Spengler, D. Mol. Endocrinol. (2001)
- Mammary gland development and lactation are controlled by different glucocorticoid receptor activities. Reichardt, H.M., Horsch, K., Gröne, H.J., Kolbus, A., Beug, H., Hynes, N., Schütz, G. Eur. J. Endocrinol. (2001)
- Interactive regulation of Ah and glucocorticoid receptors in the synergistic induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone. Abbott, B.D., Perdew, G.H., Buckalew, A.R., Birnbaum, L.S. Toxicol. Appl. Pharmacol. (1994)
- The establishment of the long terminal repeat of the mouse mammary tumor virus into CV-1 cells allows a functional analysis of steroid receptors. Couette, B., Le Ricousse, S., Fortin, D., Rafestin-Oblin, M.E., Richard-Foy, H. Biochim. Biophys. Acta (1994)
- Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis. Jaskoll, T., Choy, H.A., Melnick, M. J. Craniofac. Genet. Dev. Biol. (1994)
- Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Wan, Y., Coxe, K.K., Thackray, V.G., Housley, P.R., Nordeen, S.K. Mol. Endocrinol. (2001)
- Development of the fetal intestine in mice lacking the glucocorticoid receptor (GR). Gartner, H., Graul, M.C., Oesterreicher, T.J., Finegold, M.J., Henning, S.J. J. Cell. Physiol. (2003)
- Evaluation of steroid receptor function by gene targeting in mice. Wintermantel, T.M., Berger, S., Greiner, E.F., Schütz, G. J. Steroid Biochem. Mol. Biol. (2005)
- RT-PCR quantification of AHR, ARNT, GR, and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone. Abbott, B.D., Schmid, J.E., Brown, J.G., Wood, C.R., White, R.D., Buckalew, A.R., Held, G.A. Toxicol. Sci. (1999)