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Gene Review

Cebpb  -  CCAAT/enhancer binding protein (C/EBP), beta

Mus musculus

Synonyms: AGP/EBP, C/EBP BETA, C/EBP beta, C/EBPbeta, CCAAT/enhancer-binding protein beta, ...
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Disease relevance of Cebpb


High impact information on Cebpb


Biological context of Cebpb


Anatomical context of Cebpb


Associations of Cebpb with chemical compounds

  • Mutations within four regulatory elements, namely, the multiple response element (MRE), AP-1, NF-IL6, and NF-kappa B sites, significantly reduce, but do not completely abrogate, inducibility by cAMP and prostaglandin E1, whereas alterations of four additional sites have no effects [13].
  • To explore this issue, we examined nuclear transcriptional regulatory factor (NF-kappaB and NF-IL-6) activation and cytokine expression in the lungs following 12 to 48 h of hyperoxia exposure [14].
  • CCAATT/enhancer binding protein (C/EBP)/NFIL-6-driven chloramphenicol acetyltransferase (CAT) reporter activity was sensitive to SB203580, indicating that C/EBP/NFIL-6 transcription factor(s) are also targets of p38 MAPK [15].
  • Reporter gene experiments suggested that humulon blocked the cyclooxygenase-2 expression mediated by NFkappaB and NF-IL6, but the intracellular glucocorticoid receptor was not involved [16].
  • Nuclear factor-IL6 (NF-IL6) binding was increased at 2 and 8 h with or without LPS in synchronous and delayed synchronous VT-exposure models [17].

Physical interactions of Cebpb

  • Region I contains LPS-related responsive elements, including a binding site for nuclear factor interleukin 6 (NF-IL6) and the kappa B binding site for NF-kappa B, suggesting that this region regulates LPS-induced expression of the mac-NOS gene [18].

Regulatory relationships of Cebpb

  • Here, we make use of the murine macrophage cells RAW264 as well as of immortalized macrophages derived from mice deficient for the transcription factor CCAAT enhancer-binding protein beta (C/EBP beta) to explore the molecular mechanisms regulating COX-2 induction in activated macrophages [9].
  • In contrast, LPS-induced DNA-binding and transcriptional activities of NF-IL6 were inhibited in DN PKC-alpha-overexpressing RAW 264.7 cells and correlated with an impairment of NF-IL6 nuclear translocation [7].
  • Base substitutions within this NFIL-6 site resulted in virtual elimination of LPS-induced IL-1 beta gene transcription [4].
  • Correlation between lentinan-specific IL-6 mRNA expression (the late expression) controlled recessively and DT-APR induction suggests that the ltn1 loci control some process(es) of IL-6 expression in the regulation step before NF-IL6 [19].
  • Inhibition of xanthine oxidase by prior feeding of a tungsten-enriched diet prevented hemorrhage-induced activation in lung cells of NF-kappa B. Incubating splenocytes in vitro with xanthine oxidase activated NF-kappa B but not NF-IL6 [20].

Other interactions of Cebpb

  • In the present study, we have investigated the impact of PKC-alpha on the activation of AP-1 and NF-IL6 in LPS-treated RAW 264.7 macrophages [7].
  • We conclude that the H2-K(b) gene belongs to target genes of the NF-IL6 (C/EBPbeta) in the course of the cellular response to TNF-alpha, and we discuss some consequences of this conclusion in a general framework of inducible expression of the H2-K(b) gene [8].
  • A DNA probe including the NF-IL6 and AP2 sites gave positive bands upon electrophoretic mobility shift assay using the nuclear extracts of MC3T3-E1 cells [6].
  • Similarly, TNF-induced activation of activator protein 1 or NF-IL-6 was not impaired in FAK-/- cells [21].
  • Although IL-6 mRNA levels correlated with NFkappaB and NF-IL6 activation, tumor necrosis factor-alpha mRNA levels did not, in that they preceded transcription factor activation [2].

Analytical, diagnostic and therapeutic context of Cebpb


  1. Nuclear factor interleukin 6 motifs mediate tissue-specific gene transcription in hypoxia. Yan, S.F., Zou, Y.S., Mendelsohn, M., Gao, Y., Naka, Y., Du Yan, S., Pinsky, D., Stern, D. J. Biol. Chem. (1997) [Pubmed]
  2. Early activation of pulmonary nuclear factor kappaB and nuclear factor interleukin-6 in polymicrobial sepsis. Browder, W., Ha, T., Chuanfu, L., Kalbfleisch, J.H., Ferguson, D.A., Williams, D.L. The Journal of trauma. (1999) [Pubmed]
  3. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Tanaka, T., Akira, S., Yoshida, K., Umemoto, M., Yoneda, Y., Shirafuji, N., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. Cell (1995) [Pubmed]
  4. Upstream NFIL-6-like site located within a DNase I hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1 beta gene. Godambe, S.A., Chaplin, D.D., Takova, T., Bellone, C.J. J. Immunol. (1994) [Pubmed]
  5. Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Jenkins, N.A., Gilbert, D.J., Cho, B.C., Strobel, M.C., Williams, S.C., Copeland, N.G., Johnson, P.F. Genomics (1995) [Pubmed]
  6. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. Yamamoto, K., Arakawa, T., Ueda, N., Yamamoto, S. J. Biol. Chem. (1995) [Pubmed]
  7. Modulation of lipopolysaccharide-induced NF-IL6 activation by protein kinase C-alpha in a mouse macrophage cell line. Chano, F., Descoteaux, A. Eur. J. Immunol. (2002) [Pubmed]
  8. Transcription factor NF-IL6 (C/EBPbeta) activates the expression of the mouse MHC class I H2-Kb gene in response to TNF-alpha via the intragenic downstream regulatory element. Hatina, J., Jansa, P., Reischig, J. J. Interferon Cytokine Res. (2002) [Pubmed]
  9. The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors. Caivano, M., Gorgoni, B., Cohen, P., Poli, V. J. Biol. Chem. (2001) [Pubmed]
  10. PGG-Glucan activates NF-kappaB-like and NF-IL-6-like transcription factor complexes in a murine monocytic cell line. Adams, D.S., Pero, S.C., Petro, J.B., Nathans, R., Mackin, W.M., Wakshull, E. J. Leukoc. Biol. (1997) [Pubmed]
  11. Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Miyamoto, A., Nakayama, K., Imaki, H., Hirose, S., Jiang, Y., Abe, M., Tsukiyama, T., Nagahama, H., Ohno, S., Hatakeyama, S., Nakayama, K.I. Nature (2002) [Pubmed]
  12. Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification. Ford, A.M., Bennett, C.A., Healy, L.E., Towatari, M., Greaves, M.F., Enver, T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Dendorfer, U., Oettgen, P., Libermann, T.A. Mol. Cell. Biol. (1994) [Pubmed]
  14. Hyperoxia activates NF-kappaB and increases TNF-alpha and IFN-gamma gene expression in mouse pulmonary lymphocytes. Shea, L.M., Beehler, C., Schwartz, M., Shenkar, R., Tuder, R., Abraham, E. J. Immunol. (1996) [Pubmed]
  15. The role of p38 mitogen-activated protein kinase in IL-1 beta transcription. Baldassare, J.J., Bi, Y., Bellone, C.J. J. Immunol. (1999) [Pubmed]
  16. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. Yamamoto, K., Wang, J., Yamamoto, S., Tobe, H. FEBS Lett. (2000) [Pubmed]
  17. Effects of vomitoxin (deoxynivalenol) on the binding of transcription factors AP-1, NF-kappaB, and NF-IL6 in raw 264.7 macrophage cells. Wong, S.S., Zhou, H.R., Pestka, J.J. J. Toxicol. Environ. Health Part A (2002) [Pubmed]
  18. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Lowenstein, C.J., Alley, E.W., Raval, P., Snowman, A.M., Snyder, S.H., Russell, S.W., Murphy, W.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Two genes controlling acute phase responses by the antitumor polysacch aride, lentinan. Maeda, Y.Y., Takahama, S., Kohara, Y., Yonekawa, H. Immunogenetics (1996) [Pubmed]
  20. Hemorrhage activates NF-kappa B in murine lung mononuclear cells in vivo. Shenkar, R., Schwartz, M.D., Terada, L.S., Repine, J.E., McCord, J., Abraham, E. Am. J. Physiol. (1996) [Pubmed]
  21. Tumor necrosis factor-induced nuclear factor kappaB activation is impaired in focal adhesion kinase-deficient fibroblasts. Funakoshi-Tago, M., Sonoda, Y., Tanaka, S., Hashimoto, K., Tago, K., Tominaga, S., Kasahara, T. J. Biol. Chem. (2003) [Pubmed]
  22. Regulation of NFIL-6 and IL-6 expression by basic fibroblast growth factor in osteoblasts. Hurley, M.M., Abreu, C., Marcello, K., Kawaguchi, H., Lorenzo, J., Kalinowski, J., Ray, A., Gronowicz, G. J. Bone Miner. Res. (1996) [Pubmed]
  23. Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene. Shiina, T., Morimatsu, M., Kitamura, H., Ito, T., Kidou, S., Matsubara, K., Matsuda, Y., Saito, M., Syuto, B. Immunogenetics (2001) [Pubmed]
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