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Chemical Compound Review:

Ac-His-OH (2S)-2-acetamido-3-(3H- imidazol-4...

Synonyms: SureCN61371, SureCN468830, AG-D-07165, CHEBI:16437, AC1Q5QPS, ...

Drescher, M.J. et al., Koreishi, M. et al., O'Dowd, J.J. et al., Kamel, R.S. et al.

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High impact information on C02997

The hair cell histidine-containing unknown, present in millimolar concentration, has been identified as N-acetylhistidine by the hydrolysis and rechromatography of fractions from cation-exchange HPLC [1].
The large and specific presence of N-acetylhistidine in the hair cell preparation, together with electrophysiological evidence for its facilitatory action on afferent fibers in the frog semicircular canal, is suggestive of a role for this molecule as well as glutamate in acousticolateralis receptoneural transmission [1].
Hydrolysis of N-acetyl-L-methionine and N-acetyl-L-histidine followed Michaelis-Menten kinetics with K(m) values of 1.3+/-0.1 mM and 2.7+/-0.1 mM respectively [2].
Examination of frog cardiac muscle confirmed the presence of N-acetylhistidine and also indicated the presence of its 1-methyl derivative [3].

Analytical, diagnostic and therapeutic context of C02997

With the iodinated N-acetyl-L-histidine derivative we developed a magnetizable solid-phase second-antibody radioimmunoassay [4].

References

N-acetylhistidine, glutamate, and beta-alanine are concentrated in a receptor cell layer of the trout inner ear. Drescher, M.J., Drescher, D.G. J. Neurochem. (1991) [Pubmed]
Purification and characterization of a novel aminoacylase from Streptomyces mobaraensis. Koreishi, M., Asayama, F., Imanaka, H., Imamura, K., Kadota, M., Tsuno, T., Nakanishi, K. Biosci. Biotechnol. Biochem. (2005) [Pubmed]
Detection, characterisation, and quantification of carnosine and other histidyl derivatives in cardiac and skeletal muscle. O'Dowd, J.J., Robins, D.J., Miller, D.J. Biochim. Biophys. Acta (1988) [Pubmed]
Novel 125I-labeled nortriptyline derivatives and their use in liquid-phase or magnetizable solid-phase second-antibody radioimmunoassays. Kamel, R.S., Landon, J., Smith, D.S. Clin. Chem. (1979) [Pubmed]

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