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Chemical Compound Review:

Tetrabase 4-[(4- dimethylaminophenyl)methyl]- N,N...

Synonyms: Tetra-base, Methylene base, Arnolds base, Methane base, CCRIS 390, ...

Weisburger, E.K. et al., Kitahori, Y. et al., Gao, H.L. et al.

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Disease relevance of C14135

Feeding 4,4'-methylenebis(N,N-dimethyl)benzenamine [CAS: 101-61-1; 4,4'-methylenebis(N,N-dimethylaniline)] to inbred F344 rats increased the incidence of thyroid lesions (hyperplasia, adenomas, and carcinomas) in both sexes, especially in the female rats [1].

High impact information on C14135

The promotive effect of 4,4'-methylenebis(N,N-dimethyl)benzenamine (MDBA) on 2-stage thyroid tumorigenesis induced by N-bis(2-hydroxypropyl)nitrosamine (DHPN) in Wistar male rats was investigated [2].

Analytical, diagnostic and therapeutic context of C14135

Sequence analysis reveals that GMA induces two classes of mutations: deletion of the mono-, di- or tetra-base or the insertion of mono- or di-base [3].

References

Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline. Weisburger, E.K., Murthy, A.S., Lilja, H.S., Lamb, J.C. J. Natl. Cancer Inst. (1984) [Pubmed]
Promotive effect of 4,4'-methylenebis(N,N-dimethyl)benzenamine on N-bis(2-hydroxypropyl)nitrosamine-induced thyroid tumors in Wistar rats. Kitahori, Y., Hiasa, Y., Katoh, Y., Konishi, N., Ohshima, M., Hashimoto, H., Minami, S., Sakaguchi, Y. Cancer Lett. (1988) [Pubmed]
Spectrum of glycidyl methacrylate-induced mutation in plasmid-Escherichia coli system. Gao, H.L., Zuo, J., Fang, F.D. Biomed. Environ. Sci. (1994) [Pubmed]

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