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Chemical Compound Review

DHPN     N,N-bis(2- hydroxypropyl)nitrous amide

Synonyms: DIPN, CCRIS 459, CHEMBL350868, AG-F-84439, LS-7589, ...
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Disease relevance of N,N-Di-(2-hydroxypropyl)nitrosamine


High impact information on N,N-Di-(2-hydroxypropyl)nitrosamine


Chemical compound and disease context of N,N-Di-(2-hydroxypropyl)nitrosamine


Biological context of N,N-Di-(2-hydroxypropyl)nitrosamine


Anatomical context of N,N-Di-(2-hydroxypropyl)nitrosamine


Associations of N,N-Di-(2-hydroxypropyl)nitrosamine with other chemical compounds


Gene context of N,N-Di-(2-hydroxypropyl)nitrosamine


Analytical, diagnostic and therapeutic context of N,N-Di-(2-hydroxypropyl)nitrosamine


  1. FHIT alterations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Murata, N., Tsutsumi, M., Konishi, Y., Nakae, D. Carcinogenesis (2001) [Pubmed]
  2. Prostatic cancer induced in MRC rats by N-nitrosobis(2-oxopropyl)-amine and N-nitrosobis(2-hydroxypropyl)amine. Pour, P.M. Carcinogenesis (1983) [Pubmed]
  3. Bile acid load on the DNA distribution pattern of bile ductules and cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters. Kinami, Y., Miyakoshi, M., Fujikawa, K. Oncology (1998) [Pubmed]
  4. Lack of modification by environmental estrogenic compounds of thyroid carcinogenesis in ovariectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN). Son, H.Y., Nishikawa, A., Ikeda, T., Furukawa, F., Hirose, M. Jpn. J. Cancer Res. (2000) [Pubmed]
  5. Ki-ras activation in pancreatic carcinomas of Syrian hamsters induced by N-nitrosobis(2-hydroxypropyl)amine. Ushijima, T., Tsutsumi, M., Sakai, R., Ishizaka, Y., Takaku, F., Konishi, Y., Takahashi, M., Sugimura, T., Nagao, M. Jpn. J. Cancer Res. (1991) [Pubmed]
  6. 4,4'-Diaminodiphenylmethane: promoting effect on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine. Hiasa, Y., Kitahori, Y., Enoki, N., Konishi, N., Shimoyama, T. J. Natl. Cancer Inst. (1984) [Pubmed]
  7. Comparison of the carcinogenic effectiveness of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine, N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, and N-nitroso-2,6-dimethylmorpholine in Syrian hamsters. Lijinsky, W., Saavedra, J.E., Knutsen, G.L., Kovatch, R.M. J. Natl. Cancer Inst. (1984) [Pubmed]
  8. A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine. Pour, P., Althoff, J., Krüger, F.W., Mohr, U. J. Natl. Cancer Inst. (1977) [Pubmed]
  9. Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Tsutsumi, M., Sasaki, Y., Murata, N., Konishi, Y. Cancer Res. (2000) [Pubmed]
  10. Establishment of estrogen receptor-positive transplantable rat thyroid tumor cell lines in vivo. Hiasa, Y., Kitahori, Y., Yane, K., Nishioka, H., Nakahashi, K., Konishi, N., Ohshima, M., Okaichi, K., Ohnishi, T., Lin, J.C. Cancer Res. (1993) [Pubmed]
  11. Alterations of the M6p/Igf2 receptor gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Tsutsumi, M., Konishi, Y. Mol. Carcinog. (2003) [Pubmed]
  12. Induction of epithelial neoplasms by local application of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-acetoxypropyl)amine. Pour, P., Althoff, J., Nagel, D. Cancer Lett. (1977) [Pubmed]
  13. Promoting effect of phenobarbital on N-bis (2-hydroxypropyl)nitrosamine thyroid tumorigenesis in rats. Effect of varying duration of exposure to phenobarbital. Hiasa, Y., Kitahori, Y., Konishi, N., Enoki, N., Fujita, T. IARC Sci. Publ. (1984) [Pubmed]
  14. Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats. Imai, T., Hasumura, M., Cho, Y.M., Onose, J., Hirose, M. Cancer Sci. (2007) [Pubmed]
  15. Alkylation of rodent tissue DNA induced by N-nitrosobis(2-hydroxypropyl)amine. Kokkinakis, D.M. Carcinogenesis (1992) [Pubmed]
  16. Metabolism and activation of the pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine by isolated hepatocytes and pancreatic cells of the Syrian hamster. Mangino, M.M., Scarpelli, D.G., Kokkinakis, D.M. Carcinogenesis (1990) [Pubmed]
  17. Aberrant methylation patterns of the Rassf1a gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Shimizu, K., Kato, A., Shigemura, M., Fujii, H., Honoki, K., Tsujiuchi, T. Mol. Carcinog. (2006) [Pubmed]
  18. Reduced expression of the Connexin26 gene and its aberrant DNA methylation in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine. Shimizu, K., Shimoichi, Y., Hinotsume, D., Itsuzaki, Y., Fujii, H., Honoki, K., Tsujiuchi, T. Mol. Carcinog. (2006) [Pubmed]
  19. Frequent mutations of Ki-ras but no mutations of Ha-ras and p53 in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Kitada, H., Tsutsumi, M., Tsujiuchi, T., Takahama, M., Fukuda, T., Narita, N., Konsihi, Y. Mol. Carcinog. (1996) [Pubmed]
  20. Relationship between goblet cells and carcinoma of the pancreas during N-nitrosobis(2-hydroxypropyl)amine-induced carcinogenesis in Syrian golden hamsters. Ishikawa, O., Wada, A., Oohigashi, H., Imaoka, S., Iwanaga, T. Cancer Res. (1984) [Pubmed]
  21. Carcinogenic effect of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a postulated proximate pancreatic carcinogen in Syrian hamsters. Pour, P., Wallcave, L., Gingell, R., Nagel, D., Lawson, T., Salmasi, S., Tines, S. Cancer Res. (1979) [Pubmed]
  22. The effect of N-nitrosobis(2-hydroxypropyl)amine on pulmonary neuroepithelial cells in Syrian golden hamsters. Tateishi, R., Ishikawa, O. Am. J. Pathol. (1985) [Pubmed]
  23. Influence of incomplete bile duct obstruction on the occurrence of cholangiocarcinoma induced by diisopropanolnitrosamine in hamsters. Kinami, Y., Ashida, Y., Seto, K., Takashima, S., Kita, I. Oncology (1990) [Pubmed]
  24. Sex differential and dose dependence of phenobarbital-promoting activity in N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats. Hiasa, Y., Kitahori, Y., Konishi, N., Shimoyama, T., Lin, J.C. Cancer Res. (1985) [Pubmed]
  25. Combined effects of cholecystectomy and lithocholic acid on pancreatic carcinogenesis of N-nitrosobis(2-hydroxypropyl)amine in Syrian golden hamsters. Ura, H., Makino, T., Ito, S., Tsutsumi, M., Kinugasa, T., Kamano, T., Ichimiya, H., Konishi, Y. Cancer Res. (1986) [Pubmed]
  26. Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent. Shibata, A., Kamada, N., Masumura, K., Nohmi, T., Kobayashi, S., Teraoka, H., Nakagama, H., Sugimura, T., Suzuki, H., Masutani, M. Oncogene (2005) [Pubmed]
  27. Inhibition by catechol and di(2-ethylhexyl)phthalate of pancreatic carcinogenesis after initiation with N-nitrosobis(2-hydroxypropyl)amine in Syrian hamsters. Maruyama, H., Amanuma, T., Tsutsumi, M., Tsujiuchi, T., Horiguchi, K., Denda, A., Konishi, Y. Carcinogenesis (1994) [Pubmed]
  28. Mutations of the Smad2 and Smad4 genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Tsutsumi, M., Konishi, Y. Mol. Carcinog. (2000) [Pubmed]
  29. Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Tsutsumi, M., Konishi, Y. Cancer Lett. (2001) [Pubmed]
  30. Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine. Kitayama, W., Denda, A., Yoshida, J., Sasaki, Y., Takahama, M., Murakawa, K., Tsujiuchi, T., Tsutsumi, M., Konishi, Y. Cancer Lett. (2000) [Pubmed]
  31. Carcinogenic potency of N-nitrosomethyl(2-hydroxypropyl)amine and other metabolic relatives of N-nitrosobis(2-hydroxypropyl)amine by single intraperitoneal injection on the lung of rats. Yokose, Y., Yamamoto, K., Nakajima, A., Eimoto, H., Maruyama, H., Mori, Y., Konishi, Y. Jpn. J. Cancer Res. (1988) [Pubmed]
  32. Dose- and sex-related carcinogenesis by N-bis(2-hydroxypropyl)nitrosamine in Wistar rats. Moreira, E.L., de Camargo, J.L., Rodrigues, M.A., Barbisan, L.F., Salvadori, D.M. Jpn. J. Cancer Res. (2000) [Pubmed]
  33. The promoting effects of food dyes, erythrosine (Red 3) and rose bengal B (Red 105), on thyroid tumors in partially thyroidectomized N-bis(2-hydroxypropyl)-nitrosamine-treated rats. Hiasa, Y., Ohshima, M., Kitahori, Y., Konishi, N., Shimoyama, T., Sakaguchi, Y., Hashimoto, H., Minami, S., Kato, Y. Jpn. J. Cancer Res. (1988) [Pubmed]
  34. Greater inhibitory effects for testosterone than castration in rat thyroid tumorigenesis initiated by N-bis(2-hydroxypropyl)nitrosamine. Kitahori, Y., Ohshima, M., Nakaoka, S., Fukumoto, M., Hiasa, Y. Cancer Lett. (1989) [Pubmed]
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