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Chemical Compound Review

PubChem11254     2-amino-5-methyl-phenol

Synonyms: SureCN33821, CPD-9147, CCRIS 8309, AG-K-81201, ACMC-209h29, ...
 
 
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Disease relevance of NSC322874

  • Abiotic oxidative dimerization of 6-amino-m-cresol, observed during growth of the Mycobacterium strain, yielded a yellow dihydrophenoxazinone [1].
  • 2-Amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 microg/ml and 2 microg/ml with maximal antiviral acitivity at 1 microg/ml [2].
 

High impact information on NSC322874

References

  1. A new 4-nitrotoluene degradation pathway in a Mycobacterium strain. Spiess, T., Desiere, F., Fischer, P., Spain, J.C., Knackmuss, H.J., Lenke, H. Appl. Environ. Microbiol. (1998) [Pubmed]
  2. Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus. Iwata, A., Yamaguchi, T., Sato, K., Izumi, R., Tomoda, A. Tohoku J. Exp. Med. (2003) [Pubmed]
  3. Antitumor activity of 2-amino-4,4alpha-dihydro-4alpha, 7-dimethyl-3H-phenoxazine-3-one against Meth A tumor transplanted into BALB/c mice. Mori, H., Honda, K., Ishida, R., Nohira, T., Tomoda, A. Anticancer Drugs (2000) [Pubmed]
  4. Phenoxazinone synthesis by human hemoglobin. Tomoda, A., Hamashima, H., Arisawa, M., Kikuchi, T., Tezuka, Y., Koshimura, S. Biochim. Biophys. Acta (1992) [Pubmed]
 
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