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Chemical Compound Review:

Heptan-3-on heptan-3-one

Synonyms: Heptan-3-one, Eptan-3-one, H6511_ALDRICH, NSC-8448, ACMC-1BP93, ...

Phillips, M. et al., Martin, L.E. et al., O'Donoghue, J.L. et al.

Phillips, Cataneo, Condos, Ring Erickson, Greenberg, La Bombardi, Munawar, Tietje,

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Disease relevance of heptan-3-one

The most abundant were naphthalene, 1-methyl-, 3-heptanone, methylcyclododecane, heptane, 2,2,4,6,6-pentamethyl-, benzene, 1-methyl-4-(1-methylethyl)-, and cyclohexane, 1,4-dimethyl-. Breath VOCs were assayed by GC/MS in 42 patients hospitalized for suspicion of pulmonary tuberculosis and in 59 healthy controls [1].

High impact information on heptan-3-one

Ethyl n-butyl ketone (EBK, 3-heptanone) has not been reported to produce neurotoxicity in previous studies when it was given by oral or inhalation routes [2].
The second method is based on the ion pair extraction of salbutamol into heptan-3-one and its determination by gas chromatography mass spectrometry as the t-butyldimethylsilyl ether [3].

References

Volatile biomarkers of pulmonary tuberculosis in the breath. Phillips, M., Cataneo, R.N., Condos, R., Ring Erickson, G.A., Greenberg, J., La Bombardi, V., Munawar, M.I., Tietje, O. Tuberculosis (Edinburgh, Scotland) (2007) [Pubmed]
Further studies on ketone neurotoxicity and interactions. O'Donoghue, J.L., Krasavage, W.J., DiVincenzo, G.D., Katz, G.V. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
Quantitative determination of salbutamol in plasma, as either its trimethylsilyl or t-butyldimethylsilyl ether, using a stable isotope multiple ion recording technique. Martin, L.E., Rees, J., Tanner, R.J. Biomed. Mass Spectrom. (1976) [Pubmed]

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