Disease relevance of cyclohexane

• The accumulation of histone H10 (also denoted IP 25) in murine erythroleukemia cells, induced to differentiate with hexamethylene bis-acetamide, was shown to precede by 15-20 h the appearance in the culture of cells irreversibly committed to differentiate [1].
• A further Mar mutant was detected among 11 fluoroquinolone-resistant, cyclohexane-susceptible E. coli strains used as controls [2].
• Incorporation of a cyclohexane side chain in 1,2-cis-2,3-trans-3-aziridin-1-yl-2-hydroxy-1-(2-nitroimidazol+ ++-1- yl)cyclohexane (26) abolished hypoxia-selective toxicity and unexpectedly reduced radiosensitizing efficiency [3].
• Evaluation of selected derivatives against a clinical isolate of HIV-1 (HE strain) revealed that the hexamethylene derivative was the most potent compound [4].
• The cyclohexane triones are a novel group of synthetic antibacterial agents that are active against gram-positive bacteria, Haemophilus influenzae, and Mycobacterium smegmatis [5].

Psychiatry related information on cyclohexane

• In this work, complementary experimental and theoretical techniques are employed to address the radical-chain initiation in the autoxidation of cyclohexane with a particular focus on the "lighting-off" of the oxidation by (added) cyclohexanone [6].

High impact information on cyclohexane

• Encapsulation of aromatic guests in chloroform solution and of cyclohexane in p-xylene solution was demonstrated by nuclear magnetic resonance experiments [7].
• To investigate the influence of core packing on the oligomeric structure of a coiled coil, we engineered a GCN4 leucine zipper mutant that switches from two to three strands upon binding the hydrophobic ligands cyclohexane and benzene [8].
• TPA causes an inhibition of expression of all hexamethylene bisacetamide-inducible erythroid characteristics measured, including commitment to terminal cell division, accumulation of globin mRNA, and synthesis of globins, spectrin, heme synthetic enzymes (delta-aminolevulinic acid dehydratase and uroporphyrinogen-I synthase) and heme [9].
• The addition of sodium butyrate and hexamethylene bisacteamide which induce markers of enterocyte differentiation decreased the levels of both forms of calretinin more than 90% [10].
• The SE of cyclohexane has been estimated to be 2.2 kcal/mol at the CBS-APNO level of theory [11].

Chemical compound and disease context of cyclohexane

• Escherichia coli K-12 strains are normally tolerant to n-hexane and susceptible to cyclohexane [12].
• The patients regularly sniffed a lacquer thinner (major component toluene) or a cement (xylene and cyclohexane) for 2 to 6 years before the development of urolithiasis [13].
• OBJECTIVE: To determine the effect of growth of five strains of Salmonella enterica and their isogenic multiply antibiotic-resistant (MAR) derivatives with a phenolic farm disinfectant or triclosan (biocides) upon the frequency of mutation to resistance to antibiotics or cyclohexane [14].
• Passage of the marA::gfp reporter mutant with increasing levels of tetracycline, a method reported to select for mar mutants in Escherichia coli, led to both multiple-antibiotic and cyclohexane resistance [15].
• We have used the whole cell patch clamp method and fura-2 fluorescence imaging to study the actions of gabapentin (1-(aminoethyl) cyclohexane acetic acid) on voltage-activated Ca(2+) entry into neonatal cultured dorsal root ganglion (DRG) neurones and differentiated F-11 (embryonic rat DRG x neuroblastoma hybrid) cells [16].

Biological context of cyclohexane

• This result indicates that the kinetics of hydrogen-atom abstraction are strongly affected by the cyano group and rationalizes the lack of experimental evidence for solvent hydroxylation in competition with that of substrates such as cyclohexane [17].
• We report the DNA binding site preferences of the novel molecule AO-Pt, in which the anticancer drug dichloro(ethylenediamine)platinum(II) is linked by a hexamethylene chain to acridine orange [18].
• The sample preparation steps required for serum materials are alkaline hydrolysis and an extraction of the cholesterol into the cyclohexane phase [19].
• In the assay that measured the inhibition of HIV-1-induced cytopathogenesis in human peripheral blood lymphocytes, the hexamethylene compound emerged as the most active derivative, demonstrating a 50% inhibitory concentration of 1.3 microM [4].
• In agreement with structure-activity relationships of other chxn-containing platinum(II) complexes both [(bis(phosphonomethyl)amino-kappaN)acetato-kappaO(2-)](trans-cyclohexane-1,2-diamine)platinum(II) complexes show superior potency than the corresponding cis-congener whereas the trans-R,R isomer displays the highest activity [20].

Anatomical context of cyclohexane

• Therefore a simple sensitive spectrophotometric assay for determining levels of cytochrome P-450-dependent cyclohexane hydroxylation activity in breast and uterine microsomes (microsomal fractions) has been developed [21].
• For the membrane-based separation of benzene/cyclohexane mixtures, the pervaporation properties of different 6FDA (4,4'-hexafluoroisopropylidene diphthalic anhydride) based copolyimide membranes have been investigated [22].
• In addition, using our TPA-sensitive and resistant cell lines, we observed that the hexamethylene bis-acetamide induced pattern of oncogene expression is unperturbed by TPA, regardless of whether the cells are differentiating or not [23].
• Effect of 1-methyl cyclohexane carboxylic acid on electrical activity of Purkinje cells in the rat: evidence for a potentiation of intracerebellar inhibition [24].
• The aim of the present study was to examine the effects of N-(2-(4-2-methoxphenyl)-1-piperazinyl)ethyl)-N-(2-pyridnyl) cyclohexane carboxamide (WAY 100635) on 5-HT1A receptor-mediated responses in the dorsal raphe nucleus (DRN) and the CA1 hippocampal region [25].

Associations of cyclohexane with other chemical compounds

• The SE of cyclopropane has been increased to 28.6 kcal/mol after correction for the one-half of the SE of cyclohexane [11].
• By means of adiabatic scanning calorimetry, we have studied the effect of the nonmesogenic solutes cyclohexane (CH) and biphenyl (BP) on the nematic-smectic-A phase transition in the liquid crystal octylcyanobiphenyl (8CB) [26].
• In both clones, chemical agents, i.e. 1-methyl cyclohexane carboxylic acid (CCA) or dimethyl sulfoxide (DMSO), induce a decrease in c-myc expression [27].
• We found that on average the Ccap position is 70% buried and noted a significant correlation (R=0.8) between the relative burial of this residue and its hydrophobicity as defined by the Gibbs energy of transfer from octanol or cyclohexane to water [28].
• ACTH-stimulated pregnenolone synthesis was inhibited by AY-9944 [trans-1,4-bis-(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride; an inhibitor of cholesterol biosynthesis] [29].

Gene context of cyclohexane

• Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells [30].
• Multicopy expression of mar, soxS, or robA induced cyclohexane tolerance in strains with a deleted or inactivated chromosomal mar, soxRS, or robA locus; thus, each transcriptional activator acts independently of the others [12].
• We have found serendipitously that E. coli K-12 strains carrying a null mutation in mppA exhibit increased resistance to a wide spectrum of antibiotics and to cyclohexane [31].
• Metabolic studies employing expressed CYP1A2 with radiolabeled furafylline and a close analogue, cyclohexylline, where the furan ring is replaced with cyclohexane, indicate that these xanthines are bound in a 1:1 ratio to CYP1A2 protein [32].
• Complementation studies with a plasmid that constitutively expressed marA confirmed the involvement of mar in Salmonella with low-level antibiotic resistance and cyclohexane resistance, although the involvement of mar in down regulation of OmpF was unclear [15].

Analytical, diagnostic and therapeutic context of cyclohexane

• Here, we report measurements obtained with an extended surface forces apparatus, which makes use of fast spectral correlation to gain insight into the behavior of a thin film of cyclohexane confined within attoliter volumes, with simultaneous measurement of film thickness and refractive index [33].
• After partition extraction of the water sample, the empore disk was extracted with cyclohexane, and total molar concentrations were determined in these extracts using vapor pressure osmometry (VPO) and gas chromatography/mass spectrometry (GC/MS), respectively [34].
• Surprisingly, pi-pi interactions combined with extensive dispersive interactions, which also encompass cyclohexane, one of the crystallization solvents, win over putative hydrogen bonding [35].
• The lecithin is prepared in solvent-free form for weighing by lyophilization from cyclohexane [36].
• A variety of heterogeneous catalysts for the radical chain oxidation of cyclohexane has been prepared by immobilization of the well-defined cobalt acetate oligomers [py(3)Co(3)(mu(3)-O)(OH)(O(2)CCH(3))(5)](PF(6)) (1) and [py(4)Co(2)(OH)(2)(O(2)CCH(3))(3)](PF(6)) (2) on carboxy-modified mesoporous silica supports A-D by carboxylate exchange [37].

References