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Chemical Compound Review

Camphogen     1-methyl-4-propan-2-yl-benzene

Synonyms: Dolcymene, Paracymol, CYMENE, Paracymene, Cymol, ...
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Disease relevance of p-cymene


High impact information on p-cymene


Chemical compound and disease context of p-cymene


Biological context of p-cymene


Anatomical context of p-cymene

  • The oils of oregano plants were strongly characterized by p-cymene (16.8-24.9%), gamma-terpinene (16.8-24.9%), thymol (8.4-36.0%), and carvacrol (1.1-29.7%), a thymol chemotype for Origanum floribundum and a alpha-terpineol chemotype for Thymus numidicus being described for the first time [15].
  • The metabolism of p-cymene by liver microsomes from the possum, koala and rat (an animal whose diet is not terpene-rich) was examined [12].

Associations of p-cymene with other chemical compounds


Gene context of p-cymene

  • Treatment of mice with the other volatile oil constituents, p-cymene or alpha-pinene did not induce any changes in the serum ALT measured [20].

Analytical, diagnostic and therapeutic context of p-cymene


  1. p-Cymene pathway in Pseudomonas putida: selective enrichment of defective mutants by using halogenated substrate analogs. Wigmore, G.J., Ribbons, D.W. J. Bacteriol. (1980) [Pubmed]
  2. Plant compounds that induce polychlorinated biphenyl biodegradation by Arthrobacter sp. strain B1B. Gilbert, E.S., Crowley, D.E. Appl. Environ. Microbiol. (1997) [Pubmed]
  3. Increase in activity of essential oil components carvacrol and thymol against Escherichia coli O157:H7 by addition of food stabilizers. Burt, S.A., Vlielander, R., Haagsman, H.P., Veldhuizen, E.J. J. Food Prot. (2005) [Pubmed]
  4. Enhanced fumigant toxicity of p-cymene against Frankliniella occidentalis by simultaneous application of elevated levels of carbon dioxide. Janmaat, A.F., de Kogel, W.J., Woltering, E.J. Pest Manag. Sci. (2002) [Pubmed]
  5. Bioluminescent bioreporter integrated-circuit sensing of microbial volatile organic compounds. Ripp, S., Daumer, K.A., McKnight, T., Levine, L.H., Garland, J.L., Simpson, M.L., Sayler, G.S. J. Ind. Microbiol. Biotechnol. (2003) [Pubmed]
  6. Plasmid control of the Pseudomonas aeruginosa and Pseudomonas putida phenotypes and of linalool and p-cymene oxidation. de Smet, M.J., Friedman, M.B., Gunsalus, I.C. J. Bacteriol. (1989) [Pubmed]
  7. p-Cymene pathway in Pseudomonas putida: ring cleavage of 2,3-dihydroxy-p-cumate and subsequent reactions. DeFrank, J.J., Ribbons, D.W. J. Bacteriol. (1977) [Pubmed]
  8. Expansion of growth substrate range in Pseudomonas putida F1 by mutations in both cymR and todS, which recruit a ring-fission hydrolase CmtE and induce the tod catabolic operon, respectively. Choi, E.N., Cho, M.C., Kim, Y., Kim, C.K., Lee, K. Microbiology (Reading, Engl.) (2003) [Pubmed]
  9. Biotransformations catalyzed by cloned p-cymene monooxygenase from Pseudomonas putida F1. Nishio, T., Patel, A., Wang, Y., Lau, P.C. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  10. Volatile biomarkers of pulmonary tuberculosis in the breath. Phillips, M., Cataneo, R.N., Condos, R., Ring Erickson, G.A., Greenberg, J., La Bombardi, V., Munawar, M.I., Tietje, O. Tuberculosis (Edinburgh, Scotland) (2007) [Pubmed]
  11. Terpenoids biotransformation in mammals III: Biotransformation of alpha-pinene, beta-pinene, pinane, 3-carene, carane, myrcene, and p-cymene in rabbits. Ishida, T., Asakawa, Y., Takemoto, T., Aratani, T. Journal of pharmaceutical sciences. (1981) [Pubmed]
  12. Microsomal metabolism and enzyme kinetics of the terpene p-cymene in the common brushtail possum (Trichosurus vulpecula), koala (Phascolarctos cinereus) and rat. Pass, G.J., McLean, S., Stupans, I., Davies, N.W. Xenobiotica (2002) [Pubmed]
  13. Four weeks' inhalation exposure of rats to p-cymene affects regional and synaptosomal neurochemistry. Lam, H.R., Ladefoged, O., Ostergaard, G., Lund, S.P., Simonsen, L. Pharmacol. Toxicol. (1996) [Pubmed]
  14. Identification and expression of the cym, cmt, and tod catabolic genes from Pseudomonas putida KL47: expression of the regulatory todST genes as a factor for catabolic adaptation. Lee, K., Ryu, E.K., Choi, K.S., Cho, M.C., Jeong, J.J., Choi, E.N., Lee, S.O., Yoon, D.Y., Hwang, I., Kim, C.K. J. Microbiol. (2006) [Pubmed]
  15. Composition of the essential oils of Thymus and Origanum species from Algeria and their antioxidant and antimicrobial activities. Hazzit, M., Baaliouamer, A., Faleiro, M.L., Miguel, M.G. J. Agric. Food Chem. (2006) [Pubmed]
  16. Melaleuca oil (tea tree oil) dermatitis. Knight, T.E., Hausen, B.M. J. Am. Acad. Dermatol. (1994) [Pubmed]
  17. Antifungal activity of thyme (Thymus vulgaris L.) essential oil and thymol against moulds from damp dwellings. Segvi?? Klari??, M., Kosalec, I., Masteli??, J., Pieckov??, E., Pepeljnak, S. Lett. Appl. Microbiol. (2007) [Pubmed]
  18. In vitro analysis of the properties of Beiqishen tea. Blázovics, A., Szentmihályi, K., Lugasi, A., Balázs, A., Hagymási, K., Bányai, E., Then, M., Rapavi, E., Héthelyi, E. Nutrition (Burbank, Los Angeles County, Calif.) (2003) [Pubmed]
  19. In vitro biological activity and essential oil composition of four indigenous South African Helichrysum species. Lourens, A.C., Reddy, D., Başer, K.H., Viljoen, A.M., Van Vuuren, S.F. Journal of ethnopharmacology. (2004) [Pubmed]
  20. Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone. Mansour, M.A., Ginawi, O.T., El-Hadiyah, T., El-Khatib, A.S., Al-Shabanah, O.A., Al-Sawaf, H.A. Res. Commun. Mol. Pathol. Pharmacol. (2001) [Pubmed]
  21. Purification and properties of 2,3-dihydroxy-p-cumate-3,4-dioxygenase from Bacillus species. Ninnekar, H.Z. Biochem. Int. (1992) [Pubmed]
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