The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Bromallylene     3-bromoprop-1-ene

Synonyms: Bromoallylene, ALLYL BROMIDE, HSDB 622, NSC-7596, ACMC-1BU57, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of NSC7596

  • A dissociation of the effects of the newly synthesized quaternary ammonium narcotic antagonist, levallorphan allyl bromide (CM 32191) on morphine-induced analgesia and constipation in the mouse is reported [1].
 

High impact information on NSC7596

  • Mass spectrometric analysis of the tryptic fragments indicated that the sulfhydryl group of Cys(671) in the hDPD was modified with 5, 6-dihydro-5-(2-bromoethylydenyl)uracil (BEDU), a putative allyl bromide type of reactive molecule, to form a sulfide bond with loss of hydrogen bromide [2].
  • Base-promoted cyclization of tert-butyl [2-(benzylideneamino)phenyl]acetate (13a) and subsequent C3-alkylation with allyl bromide affords 3-allyl-2-phenyl-2,3-dihydro-1H-indole-3-carboxylic acid, tert-butyl ester (15b) in high yield as a single diastereomer [3].
  • Arylamines substituted with a large number of different substituents were converted via diazotizative deamination with tert-butyl nitrite in allyl bromide and acetonitrile to the corresponding allyl aromatic compounds [4].
  • Kinetic DNA-alkylation measurements revealed significant differences between the strongly alkylating allyl methanesulphonate and allyl bromide with half-life values of 1.5 h and 8.1 h, respectively and the weakly alkylating allyl chloride with a half-life value of 360 h [5].
  • Ethyl(R)-4-chloro-3-hydroxybutanoate ((R)-CHBE) are obtained by cetyltrimetylammonium bromide (CTAB) permeabilized fresh brewer's yeast whole cells bioconversion of ethyl 4-chloro-3-oxobutanoate (COBE ) in the presence of allyl bromide [6].
 

Associations of NSC7596 with other chemical compounds

References

  1. Pharmacological actions of levallorphan allyl bromide (CM 32191), a new peripheral narcotic antagonist. Bianchetti, A., Giudice, A., Picerno, N., Carminati, P. Life Sci. (1982) [Pubmed]
  2. Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH. Nishiyama, T., Ogura, K., Okuda, H., Suda, K., Kato, A., Watabe, T. Mol. Pharmacol. (2000) [Pubmed]
  3. Synthesis of a spirocyclic indoline lactone. Hodges, J.C., Wang, W., Riley, F. J. Org. Chem. (2004) [Pubmed]
  4. Aromatic allylation via diazotization: metal-free C-C bond formation. Ek, F., Axelsson, O., Wistrand, L.G., Frejd, T. J. Org. Chem. (2002) [Pubmed]
  5. Allylic compounds bind directly to DNA: investigation of the binding mechanisms in vitro. Eder, E., Lutz, D., Jörns, M. Chem. Biol. Interact. (1987) [Pubmed]
  6. Bioconversion of ethyl 4-chloro-3-oxobutanoate by permeabilized fresh brewer's yeast cells in the presence of allyl bromide. Yu, M.A., Wei, Y.M., Zhao, L., Jiang, L., Zhu, X.B., Qi, W. J. Ind. Microbiol. Biotechnol. (2007) [Pubmed]
  7. Optochemical sensor for an ornidazole assay using 1-amino-4-allyloxyanthraquinone as a fluorescent indicator. Tan, S.Z., Niu, C.G., Jiang, J.H., Shen, G.L., Yu, R.Q. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2005) [Pubmed]
 
WikiGenes - Universities