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Chemical Compound Review:

PubChem3870 1,4-dibromobutane

Synonyms: CCRIS 8917, AG-C-32741, AG-D-28031, ACMC-209969, ANW-16159, ...

Onkenhout, W. et al., Lu, Y. et al., Tornero-Velez, R. et al.

Lu, Irani, Grotewold, Tornero-Velez, Ross, Granville, Laskey, Jones, DeMarini, Evans,

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High impact information on NSC71435

Additional dihaloalkanes (1,2-dichloroethane, 1,2-dichloropropane, 1,4-dichlorobutane, 1,2-dibromoethane, 1,2-dibromopropane, 1,4-dibromobutane) were evaluated to assess structure-activity relationships [1].
Based on these findings, a biotransformation scheme of 1,4-dibromobutane in the rat is proposed [2].
When urines of rats treated with 1,4-dibromobutane were collected in a buffer of pH 1.0, however, only 3-hydroxysulfolane was found [2].
Once the beads were deemed adequate for the linking of small molecules by the coupling of NHS-fluorescein followed by microscopy, chemical hydrolysis and fluorometry, the flavonoid naringenin was modified with 1,4-dibromobutane, followed by the attachment of aminopropyltriethoxysilane [3].

Analytical, diagnostic and therapeutic context of NSC71435

They were identified as tetrahydrothiophene and 3-hydroxysulfolane by gas chromatography and gas chromatography-mass spectrometry and were found to be excreted in 48-hr urine, representing 5.8 +/- 1.1 and 57 +/- 15% of the dose of 1,4-dibromobutane, respectively [2].

References

Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane. Tornero-Velez, R., Ross, M.K., Granville, C., Laskey, J., Jones, J.P., DeMarini, D.M., Evans, M.V. Drug Metab. Dispos. (2004) [Pubmed]
Biotransformation and quantitative determination of sulfur-containing metabolites of 1,4-dibromobutane in the rat. Onkenhout, W., van Loon, W.M., Buijs, W., van der Gen, A., Vermeulen, N.P. Drug Metab. Dispos. (1986) [Pubmed]
Covalent attachment of the plant natural product naringenin to small glass and ceramic beads. Lu, Y., Irani, N.G., Grotewold, E. BMC chemical biology [electronic resource]. (2005) [Pubmed]

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