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Chemical Compound Review

1,2-dichloroethane     1,2-dichloroethane

Synonyms:
 
 
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Disease relevance of 1,2-dichloroethane

 

Psychiatry related information on 1,2-dichloroethane

 

High impact information on 1,2-dichloroethane

  • A self-consistent reaction field solvation model was used to examine the SN2 reactions between methyl chloride and hydroxide ion and between 1,2-dichloroethane and acetate in solution [7].
  • In vivo genotoxicity and acute hepatotoxicity of 1,2-dichloroethane in mice: comparison of oral, intraperitoneal, and inhalation routes of exposure [8].
  • In order to determine whether the covalent binding of the carcinogen 1,2-dichloroethane to macromolecules is dependent on microsomes or cytosol, microsomes and cytosol from lungs of C57BL/6 X C3H/He F1 (hereafter called B6C3F1) mice and Osborne-Mendel rats were incubated with [1,2-14C]dichloroethane and salmon sperm DNA [9].
  • However, the rate-determining step in the conversion (kcat) of 1, 2-dibromoethane and 1,2-dichloroethane was found to be release of the charged halide ion out of the active site cavity, explaining the different Km but similar kcat values for these compounds [10].
  • Rapid kinetics of electron transfer (ET) reactions across the interface between water and 1,2-dichloroethane were measured by steady-state voltammetry at nanopipet electrodes (50- to 400-nm orifice radius) [11].
 

Chemical compound and disease context of 1,2-dichloroethane

 

Biological context of 1,2-dichloroethane

 

Anatomical context of 1,2-dichloroethane

 

Associations of 1,2-dichloroethane with other chemical compounds

 

Gene context of 1,2-dichloroethane

  • We have established that the episulfonium ion of CEG can adduct PDI and may have important toxicologic significance for 1,2-dichloroethane toxicity [30].
  • For water/odichlorobenzene and water/1,2-dichloroethane interfaces [ET(30) of the oil > 35 kcal/mol], on the other hand, the interfacial polarity determined by TIR spectroscopy was lower than the ET(30)calc [31].
  • Facilitated protamine transfer at polarized water/1,2-dichloroethane interfaces studied by cyclic voltammetry and chronoamperometry at micropipet electrodes [32].
  • The haloalkane dehalogenase DhmA shows broad substrate specificity and good activity with the priority pollutant 1,2-dichloroethane [33].
  • Sensitivity of transgenic Drosophila melanogaster with expression of a human gene encoding the glutathione S-transferase alpha subunit (GSTA1-1) to 1,2:5,6-dibenzanthracene (DBA) and 1,2-dichloroethane (DCE) was investigated in the somatic mutation and recombination test (SMART) [34].
 

Analytical, diagnostic and therapeutic context of 1,2-dichloroethane

  • The lipophilicity of 28 acidic compounds with various functional groups was studied by potentiometry and cyclic voltammetry in the n-octanol/water and 1,2-dichloroethane/water systems in order to complement our understanding of the lipophilicity of neutral and ionized acids and to clarify the solvation mechanisms responsible for their partition [35].
  • The solid could be recovered by centrifugation from the three-phase (solid-liquid-liquid) system containing 1,2-dichloroethane [36].
  • 1,2-Dichloroethane (DCE) was reported to be carcinogenic in rats in a long-term bioassay using gavage in corn oil (24 and 48 mg/kg/day), but not by inhalation (up to 150-250 ppm, 7 h/day, 5 days/week) [37].
  • Early pneumotoxic effects after oral administration of 1,2-dichloroethane [38].
  • An extractive membrane bioreactor has been used to treat a synthetic waste-water containing a toxic volatile organic compound, 1,2-dichloroethane (DCE) [39].

References

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  14. Crystallization and preliminary X-ray analysis of L-2-haloacid dehalogenase from Xanthobacter autotrophicus GJ10. Ridder, I.S., Rozeboom, H.J., Kingma, J., Janssen, D.B., Dijkstra, B.W. Protein Sci. (1995) [Pubmed]
  15. Micronuclei induced in peripheral blood of E mu-PIM-1 transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane. Armstrong, M.J., Galloway, S.M. Mutat. Res. (1993) [Pubmed]
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  17. Mechanistic investigations of imine hydrogenation catalyzed by dinuclear iridium complexes. Martín, M., Sola, E., Tejero, S., López, J.A., Oro, L.A. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
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  21. Voltammetric detection of heparin at polarized blood plasma/1,2-dichloroethane interfaces. Guo, J., Yuan, Y., Amemiya, S. Anal. Chem. (2005) [Pubmed]
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  24. Erratum to Mutation spectrum of 2-chloroethyl methanesulfonate in Drosophila melanogaster premeiotic germ cells' [Mutation Res. 331 (1995) 213-224]. Fossett, N.G., Byrne, B.J., Tucker, A.B., Arbour-Reily, P., Chang, S., Lee, W.R. Mutat. Res. (1996) [Pubmed]
  25. Strain and reactivity: electrophilic addition of bromine and tribromide salts to cyclic allenes. Chiappe, C., De Rubertis, A., Detert, H., Lenoir, D., Wannere, C.S., Schleyer, P.R. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
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  27. Kinetic characterization and X-ray structure of a mutant of haloalkane dehalogenase with higher catalytic activity and modified substrate range. Schanstra, J.P., Ridder, I.S., Heimeriks, G.J., Rink, R., Poelarends, G.J., Kalk, K.H., Dijkstra, B.W., Janssen, D.B. Biochemistry (1996) [Pubmed]
  28. Photosensitized oxidation of sulfides: discriminating between the singlet-oxygen mechanism and electron transfer involving superoxide anion or molecular oxygen. Bonesi, S.M., Manet, I., Freccero, M., Fagnoni, M., Albini, A. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
  29. "In silico" design of new uranyl extractants based on phosphoryl-containing podands: QSPR studies, generation and screening of virtual combinatorial library, and experimental tests. Varnek, A., Fourches, D., Solov'ev, V.P., Baulin, V.E., Turanov, A.N., Karandashev, V.K., Fara, D., Katritzky, A.R. Journal of chemical information and computer sciences. (2004) [Pubmed]
  30. Alkylation of protein disulfide isomerase by the episulfonium ion derived from the glutathione conjugate of 1,2-dichloroethane and mass spectrometric characterization of the adducts. Kaetzel, R.S., Stapels, M.D., Barofsky, D.F., Reed, D.J. Arch. Biochem. Biophys. (2004) [Pubmed]
  31. Time-resolved total internal reflection fluorometry study on polarity at a liquid/liquid interface. Ishizaka, S., Kim, H.B., Kitamura, N. Anal. Chem. (2001) [Pubmed]
  32. Facilitated protamine transfer at polarized water/1,2-dichloroethane interfaces studied by cyclic voltammetry and chronoamperometry at micropipet electrodes. Yuan, Y., Amemiya, S. Anal. Chem. (2004) [Pubmed]
  33. Cloning and expression of the haloalkane dehalogenase gene dhmA from Mycobacterium avium N85 and preliminary characterization of DhmA. Jesenská, A., Bartos, M., Czerneková, V., Rychlík, I., Pavlík, I., Damborský, J. Appl. Environ. Microbiol. (2002) [Pubmed]
  34. Activation or detoxification of mutagenic and carcinogenic compounds in transgenic Drosophila expressing human glutathione S-transferase. Chroust, K., Jowett, T., Farid-Wajidi, M.F., Huang, J.Y., Ryskova, M., Wolf, R., Holoubek, I. Mutat. Res. (2001) [Pubmed]
  35. Lipophilicity and solvation of anionic drugs. Bouchard, G., Carrupt, P.A., Testa, B., Gobry, V., Girault, H.H. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  36. Preparation and characterization of organotin-oxomolybdate coordination polymers and their use in sulfoxidation catalysis. Abrantes, M., Valente, A.A., Pillinger, M., Gonçalves, I.S., Rocha, J., Romão, C.C. Chemistry (Weinheim an der Bergstrasse, Germany) (2003) [Pubmed]
  37. Effect of inhalation exposure regimen on DNA binding potency of 1,2-dichloroethane in the rat. Baertsch, A., Lutz, W.K., Schlatter, C. Arch. Toxicol. (1991) [Pubmed]
  38. Early pneumotoxic effects after oral administration of 1,2-dichloroethane. Salovsky, P., Shopova, V., Dancheva, V., Yordanov, Y., Marinov, E. J. Occup. Environ. Med. (2002) [Pubmed]
  39. Extraction and biodegradation of a toxic volatile organic compound (1,2-dichloroethane) from waste-water in a membrane bioreactor. Freitas dos Santos, L.M., Livingston, A.G. Appl. Microbiol. Biotechnol. (1994) [Pubmed]
 
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