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Chemical Compound Review

1,2-dichloroethane     1,2-dichloroethane

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Disease relevance of 1,2-dichloroethane


Psychiatry related information on 1,2-dichloroethane


High impact information on 1,2-dichloroethane

  • A self-consistent reaction field solvation model was used to examine the SN2 reactions between methyl chloride and hydroxide ion and between 1,2-dichloroethane and acetate in solution [7].
  • In vivo genotoxicity and acute hepatotoxicity of 1,2-dichloroethane in mice: comparison of oral, intraperitoneal, and inhalation routes of exposure [8].
  • In order to determine whether the covalent binding of the carcinogen 1,2-dichloroethane to macromolecules is dependent on microsomes or cytosol, microsomes and cytosol from lungs of C57BL/6 X C3H/He F1 (hereafter called B6C3F1) mice and Osborne-Mendel rats were incubated with [1,2-14C]dichloroethane and salmon sperm DNA [9].
  • However, the rate-determining step in the conversion (kcat) of 1, 2-dibromoethane and 1,2-dichloroethane was found to be release of the charged halide ion out of the active site cavity, explaining the different Km but similar kcat values for these compounds [10].
  • Rapid kinetics of electron transfer (ET) reactions across the interface between water and 1,2-dichloroethane were measured by steady-state voltammetry at nanopipet electrodes (50- to 400-nm orifice radius) [11].

Chemical compound and disease context of 1,2-dichloroethane


Biological context of 1,2-dichloroethane


Anatomical context of 1,2-dichloroethane


Associations of 1,2-dichloroethane with other chemical compounds


Gene context of 1,2-dichloroethane

  • We have established that the episulfonium ion of CEG can adduct PDI and may have important toxicologic significance for 1,2-dichloroethane toxicity [30].
  • For water/odichlorobenzene and water/1,2-dichloroethane interfaces [ET(30) of the oil > 35 kcal/mol], on the other hand, the interfacial polarity determined by TIR spectroscopy was lower than the ET(30)calc [31].
  • Facilitated protamine transfer at polarized water/1,2-dichloroethane interfaces studied by cyclic voltammetry and chronoamperometry at micropipet electrodes [32].
  • The haloalkane dehalogenase DhmA shows broad substrate specificity and good activity with the priority pollutant 1,2-dichloroethane [33].
  • Sensitivity of transgenic Drosophila melanogaster with expression of a human gene encoding the glutathione S-transferase alpha subunit (GSTA1-1) to 1,2:5,6-dibenzanthracene (DBA) and 1,2-dichloroethane (DCE) was investigated in the somatic mutation and recombination test (SMART) [34].

Analytical, diagnostic and therapeutic context of 1,2-dichloroethane

  • The lipophilicity of 28 acidic compounds with various functional groups was studied by potentiometry and cyclic voltammetry in the n-octanol/water and 1,2-dichloroethane/water systems in order to complement our understanding of the lipophilicity of neutral and ionized acids and to clarify the solvation mechanisms responsible for their partition [35].
  • The solid could be recovered by centrifugation from the three-phase (solid-liquid-liquid) system containing 1,2-dichloroethane [36].
  • 1,2-Dichloroethane (DCE) was reported to be carcinogenic in rats in a long-term bioassay using gavage in corn oil (24 and 48 mg/kg/day), but not by inhalation (up to 150-250 ppm, 7 h/day, 5 days/week) [37].
  • Early pneumotoxic effects after oral administration of 1,2-dichloroethane [38].
  • An extractive membrane bioreactor has been used to treat a synthetic waste-water containing a toxic volatile organic compound, 1,2-dichloroethane (DCE) [39].


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  21. Voltammetric detection of heparin at polarized blood plasma/1,2-dichloroethane interfaces. Guo, J., Yuan, Y., Amemiya, S. Anal. Chem. (2005) [Pubmed]
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  29. "In silico" design of new uranyl extractants based on phosphoryl-containing podands: QSPR studies, generation and screening of virtual combinatorial library, and experimental tests. Varnek, A., Fourches, D., Solov'ev, V.P., Baulin, V.E., Turanov, A.N., Karandashev, V.K., Fara, D., Katritzky, A.R. Journal of chemical information and computer sciences. (2004) [Pubmed]
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