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Chemical Compound Review:

DIPROPYLETHER 1-propoxypropane

Synonyms: Dipropyl ether, Dipropyl oxide, n-Propyl ether, ACMC-1C12L, PROPYL ETHER, ...

Sabarinath, S. et al., Lii, J.H. et al., Shoeib, N.A. et al., Bauguess, C.T. et al., Cho, J.Y. et al.

Sabarinath, Singh, Gupta,

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High impact information on Di-n-propyl ether

The LD50 for the propyl ether of p-N,N-bis(2-chloroethyl)aminophenol was increased by the pretreatment from 605 to 678 microns/kg [1].
This substantial (0.80 kcal/mol relative to methyl propyl ether) reduction in barrier height in the latter case is attributed mainly to the change in the bond order of the C-O bond to which the methyl is attached, as a function of conformation, which in turn is a result of the anomeric effect [2].
Compound 3c (2,5-dibromo-3,4-dihydroxybenzyl n-propyl ether) was the most active compound against both cell lines (IC(50) = 1.72 and 0.80 micromol, respectively), and its effect on the cell cycle was studied using flow cytometry [3].
Propyl ether failed to increase hepatic mEH mRNA levels [4].
A rapid, sensitive, selective and specific HPLC/ESI-MS/MS assay method was developed and validated for the simultaneous quantitation of alpha-/beta-diastereomers of arteether (AE), sulphadoxine (SDX) and pyrimethamine (PYR) in rat blood plasma using propyl ether analogue of beta-arteether as internal standard [5].

References

Effects of microsomal enzyme induction on toxicity of p-N, N-bis (2-chloroethyl)aminophenyl alkyl ethers in mice and survival times in L-1210 leukemic mice. Bauguess, C.T., Chang, S.P., Wynn, J.E. Journal of pharmaceutical sciences. (1982) [Pubmed]
The external-anomeric torsional effect. Lii, J.H., Chen, K.H., Johnson, G.P., French, A.D., Allinger, N.L. Carbohydr. Res. (2005) [Pubmed]
In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers. Shoeib, N.A., Bibby, M.C., Blunden, G., Linley, P.A., Swaine, D.J., Wheelhouse, R.T., Wright, C.W. J. Nat. Prod. (2004) [Pubmed]
Differential induction of hepatic microsomal epoxide hydrolase by alkyl sulphides and alkyl ethers in rat. Cho, J.Y., Kim, S.G. Xenobiotica (1997) [Pubmed]
Simultaneous quantification of alpha-/beta-diastereomers of arteether, sulphadoxine and pyrimethamine: A promising anti-relapse antimalarial therapeutic combination, by liquid chromatography tandem mass spectrometry. Sabarinath, S., Singh, R.P., Gupta, R.C. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2006) [Pubmed]

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