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Chemical Compound Review

Fanasil     4-amino-N-(5,6- dimethoxypyrimidin-4...

Synonyms: Fanzil, Sulfadoxin, SULFADOXINE, Sulformetoxine, Sulphormetoxin, ...
 
 
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Disease relevance of SULFADOXINE

 

High impact information on SULFADOXINE

 

Chemical compound and disease context of SULFADOXINE

 

Biological context of SULFADOXINE

 

Anatomical context of SULFADOXINE

 

Associations of SULFADOXINE with other chemical compounds

 

Gene context of SULFADOXINE

 

Analytical, diagnostic and therapeutic context of SULFADOXINE

References

  1. Fansidar-induced Stevens-Johnson Syndrome. Hornstein, O.P., Ruprecht, K.W. N. Engl. J. Med. (1982) [Pubmed]
  2. Fansidar resistant falciparum malaria in Indonesia. Rumans, L.W., Dennis, D.T., Atmosoedjono, S. Lancet (1979) [Pubmed]
  3. Fansidar and hepatic granulomas. Lazar, H.P., Murphy, R.L., Phair, J.P. Ann. Intern. Med. (1985) [Pubmed]
  4. Fansidar prophylaxis of Pneumocystis pneumonia in the acquired immunodeficiency syndrome. Fischl, M.A., Dickinson, G.M. Ann. Intern. Med. (1986) [Pubmed]
  5. Fatal toxic epidermal necrolysis during prophylaxis with pyrimethamine and sulfadoxine in a human immunodeficiency virus-infected person. Raviglione, M.C., Dinan, W.A., Pablos-Mendez, A., Palagiano, A., Sabatini, M.T. Arch. Intern. Med. (1988) [Pubmed]
  6. Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial. Staedke, S.G., Kamya, M.R., Dorsey, G., Gasasira, A., Ndeezi, G., Charlebois, E.D., Rosenthal, P.J. Lancet (2001) [Pubmed]
  7. Inadequacy of chlorproguanil 20 mg per week as chemoprophylaxis for falciparum malaria in Kenya. Watkins, W.M., Brandling-Bennett, A.D., Oloo, A.J., Howells, R.E., Gilles, H.M., Koech, D.K. Lancet (1987) [Pubmed]
  8. Plasmodium falciparum resistant to mefloquine plus sulfadoxine/pyrimethamine. Heizmann, P., Fernex, M., Leimer, R., Reber-Liske, R., Stohler, H. Lancet (1986) [Pubmed]
  9. Mefloquine and sulfadoxine/pyrimethamine resistant Plasmodium falciparum. Arnold, K. Lancet (1986) [Pubmed]
  10. Pyrimethamine/sulfadoxine for falciparum malaria. Watt, G., Shanks, G.D. Lancet (1991) [Pubmed]
  11. Trials of mefloquine in vivax and of mefloquine plus 'fansidar' in falciparum malaria. Harinasuta, T., Bunnag, D., Lasserre, R., Leimer, R., Vinijanont, S. Lancet (1985) [Pubmed]
  12. Drug therapy for Plasmodium falciparum malaria resistant to pyrimethamine-sulfadoxine (Fansidar). A study of alternate regimens in Eastern Thailand, 1980. Reacher, M., Campbell, C.C., Freeman, J., Doberstyn, E.B., Brandling-Bennett, A.D. Lancet (1981) [Pubmed]
  13. Increased carriage of trimethoprim/sulfamethoxazole-resistant Streptococcus pneumoniae in Malawian children after treatment for malaria with sulfadoxine/pyrimethamine. Feikin, D.R., Dowell, S.F., Nwanyanwu, O.C., Klugman, K.P., Kazembe, P.N., Barat, L.M., Graf, C., Bloland, P.B., Ziba, C., Huebner, R.E., Schwartz, B. J. Infect. Dis. (2000) [Pubmed]
  14. Resistance of Plasmodium falciparum malaria to sulfadoxine-pyrimethamine ('Fansidar') in a refugee camp in Thailand. Hurwitz, E.S., Johnson, D., Campbell, C.C. Lancet (1981) [Pubmed]
  15. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. Triglia, T., Wang, P., Sims, P.F., Hyde, J.E., Cowman, A.F. EMBO J. (1998) [Pubmed]
  16. Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites. Basco, L.K., Tahar, R., Ringwald, P. Antimicrob. Agents Chemother. (1998) [Pubmed]
  17. In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. Curtis, J., Duraisingh, M.T., Warhurst, D.C. J. Infect. Dis. (1998) [Pubmed]
  18. Effect of a single oral dose of Fansidar on the pharmacokinetics of halofantrine in healthy volunteers: a preliminary report. Hombhanje, F.W. British journal of clinical pharmacology. (2000) [Pubmed]
  19. Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar). Daniel, P.T., Holzschuh, J., Berg, P.A. Thorax (1989) [Pubmed]
  20. Adoptive transfer of resistance to Plasmodium berghei with spleen cells and serum from Fansidar-cured mice. Ferraroni, J.J., Speer, C.A. Infect. Immun. (1982) [Pubmed]
  21. Prophylaxis of toxoplasmosis infection with pyrimethamine/sulfadoxine (Fansidar) in bone marrow transplant recipients. Foot, A.B., Garin, Y.J., Ribaud, P., Devergie, A., Derouin, F., Gluckman, E. Bone Marrow Transplant. (1994) [Pubmed]
  22. Sulphadoxine concentrations in plasma, red blood cells and whole blood in healthy and Plasmodium falciparum malaria cases after treatment with Fansidar using high-performance liquid chromatography. Dua, V.K., Sarin, R., Sharma, V.P. Journal of pharmaceutical and biomedical analysis. (1994) [Pubmed]
  23. The chemotherapy of rodent malaria, XXXII. The influence of p-aminobenzoic acid on the transmission of Plasmodium yoelii and P. berghei by Anopheles stephensi. Peters, W., Ramkaran, A.E. Ann. Trop. Med. Parasitol. (1980) [Pubmed]
  24. Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. Nzila-Mounda, A., Mberu, E.K., Sibley, C.H., Plowe, C.V., Winstanley, P.A., Watkins, W.M. Antimicrob. Agents Chemother. (1998) [Pubmed]
  25. Potentiating effect of pyrimethamine and sulfadoxine against dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium chabaudi. Sirawaraporn, W., Yuthavong, Y. Antimicrob. Agents Chemother. (1986) [Pubmed]
  26. Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Meneau, I., Sanglard, D., Bille, J., Hauser, P.M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  27. New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A. Mack, D.G., McLeod, R. Antimicrob. Agents Chemother. (1984) [Pubmed]
  28. Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase. de Beer, T.A., Louw, A.I., Joubert, F. Bioorg. Med. Chem. (2006) [Pubmed]
  29. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Wang, P., Read, M., Sims, P.F., Hyde, J.E. Mol. Microbiol. (1997) [Pubmed]
  30. Determination of sulfadoxine concentrations in whole blood using C18 solid-phase extraction, sodium dodecyl sulfate and dimethylaminocinnamaldehyde. Green, M.D., Mount, D.L., Todd, G.D. The Analyst. (1995) [Pubmed]
  31. Effect of pyrimethamine and sulphadoxine on human lymphocyte proliferation. Bygbjerg, I.C., Odum, N., Theander, T.G. Trans. R. Soc. Trop. Med. Hyg. (1986) [Pubmed]
  32. Determination of pyrimethamine in human plasma after administration of fansidar of fansidar-mefloquine by means of high-performance liquid chromatography with fluorescence detection. Timm, U., Weidekamm, E. J. Chromatogr. (1982) [Pubmed]
  33. High-performance liquid chromatography determination of pyrimethamine, dapsone, monoacetyldapsone, sulfadoxine, and N-acetyl-sulfadoxine after rapid solid-phase extraction. Eljaschewitsch, J., Padberg, J., Schürmann, D., Ruf, B. Therapeutic drug monitoring. (1996) [Pubmed]
  34. The disposition of oral and intramuscular pyrimethamine/sulphadoxine in Kenyan children with high parasitaemia but clinically non-severe falciparum malaria. Winstanley, P.A., Watkins, W.M., Newton, C.R., Nevill, C., Mberu, E., Warn, P.A., Waruiru, C.M., Mwangi, I.N., Warrell, D.A., Marsh, K. British journal of clinical pharmacology. (1992) [Pubmed]
 
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