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Chemical Compound Review:

Undecanol undecan-1-ol

Synonyms: HENDECANOL, Tip-Nip, n-Undecanol, Undecanol-(1), Neodol 1, ...

Hammond, D.G. et al., Severin, E.S. et al., Mugele, F. et al., Wang, L. et al.

Mugele, Salmeron,

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Disease relevance of Tip-Nip

The undecanol-modified oligo namely an oligo complementary to the protein binding sites located at the influenza virus polymerases encoding RNA, was synthesized using a DNA-synthesator [1].

High impact information on Tip-Nip

In mosquitoes, we found that activity levels off after undecanol (C11) but does not disappear until after pentadecanol (C15), that it is reversible, and that chain length plays a role not only in potency, but also in the time needed to manifest toxic effects [2].

Analytical, diagnostic and therapeutic context of Tip-Nip

Multiple beam interferometry and video microscopy were used to investigate the layering transition of thin liquid films of 1-undecanol confined between atomically smooth mica surfaces [3].
Controlled rearrangement of adsorbed undecanol films on mica surfaces induced by an atomic force microscopy tip [4].

References

Hydrophobized antiviral antibodies and antisense oligonucleotides. Severin, E.S., Melik-Nubarov, N.S., Ovcharenko, A.V., Vinogradov, S.V., Kiselev, V.I., Kabanov, A.V. Adv. Enzyme Regul. (1991) [Pubmed]
Structure-activity relationship of alkanols as mosquito larvicides with novel findings regarding their mode of action. Hammond, D.G., Kubo, I. Bioorg. Med. Chem. (1999) [Pubmed]
Dynamics of layering transitions in confined liquids. Mugele, F., Salmeron, M. Phys. Rev. Lett. (2000) [Pubmed]
Controlled rearrangement of adsorbed undecanol films on mica surfaces induced by an atomic force microscopy tip. Wang, L., Wang, E. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]

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