Disease relevance of Population Groups

• This mutation was not found in the GH-receptor genomic sequences of seven unrelated subjects with Laron dwarfism who belonged to different population groups [1].
• Multiple regression analysis revealed that the exretion of estriol was significantly lower in population groups in whom breast cancer incidence was high [2].
• It remains to be seen if any association between AHSP and clinical severity is present in other population groups with a high frequency of beta thalassemia [3].
• Intensive search over the past five years for all cases of multiple sclerosis (MS) on the Faroe Island since about 1920 has revealed 25 cases among native-born resident Faroese up to 1977 [4].
• Although cause-effect relationships cannot be established by epidemiologic studies alone, we have shown in all three affected population groups that individuals develop the amyotrophic lateral sclerosis variant of this disorder after heavy exposure to the raw or incompletely detoxified seed of neurotoxic cycad plants [5].

Psychiatry related information on Population Groups

• Glucose tolerance and physical activity in a Mexican indigenous population [6].
• Conclusion: Despite no evidence in this study for allelic association of HTR1B to antisocial substance dependence, further evaluation of the hypothesized association is warranted in other population groups [7].
• Bacterial metabolism of cholesterol can be influenced by diet as evidenced by significant variations among different population groups with different dietary habits [8].
• None has examined the cholesterol-lowering effect of a low-fat vegetarian diet, which, in other population groups, leads to marked reductions in serum cholesterol concentrations and, in combination with other life-style changes, a regression of atherosclerosis [9].
• The metal loading mainly depended on the surface silanol group population, size and shape of metal-coordinated ligand, and reaction time as shown for Zn contents in the range of 4.2 to 10.6 wt% [10].

High impact information on Population Groups

• Low plasma beta-carotene levels averaging 8-12 micrograms/dl were observed among the population groups [11].
• The average plasma retinol levels ranged from 24 to 27 micrograms/dl among the population groups, with 20-35% of the individuals having levels under 20 micrograms/dl [11].
• SETTING: 2 public health department clinics in North Carolina. Participants: 121 adults who had recently emigrated from Vietnam to North Carolina and who were ethnic Vietnamese and ethnic Dega, a minority population group from the central highlands region of Vietnam [12].
• In the same population group we have studied extensively in the past, we found a higher association of a TAP1 allele with IDDM than with any single HLA-DP allele but the risk was lower than with HLA-DQB1*0302 [13].
• Apo J revealed a common two-allele polymorphism only in populations with African ancestry and was found to be monomorphic in all other population groups tested [14].

Chemical compound and disease context of Population Groups

• Since it has been shown that American blacks have the most extensive and severe degree of atherosclerosis among the three population groups, it would appear that iron, calcium and manganese in the cerebral vessels may not directly relate to the severity of cerebral atherosclerosis [15].
• Beta-carotene levels in exfoliated mucosa cells of population groups at low and elevated risk for oral cancer [16].
• Goserelin (Zoladex), a gonadotropin-releasing hormone analogue, reduces plasma/serum estrogen levels in pre- or perimenopausal women (to postmenopausal levels), and is indicated in hormone receptor-positive early breast cancer in this population group [17].
• Comparison of bisoprolol with atenolol for systemic hypertension in four population groups (young, old, black and nonblack) using ambulatory blood pressure monitoring. Bisoprolol Investigators Group [18].
• Dietary fluoride intake and the prevalence of dental fluorosis were investigated in children from three population groups (mongol, Kazak and Yugu) in Gansu Province, China. The concentration of fluoride in drinking water ranged from 0.11 to 0.32 mg/litre; there was no other fluoride pollution [19].

Biological context of Population Groups

• The existence of an asymmetric gene flow is supported by the phylogeographic features of mtDNA and Y-chromosome haplogroups found in the two population groups [20].
• The vitamin A and beta-carotene contents of breast milk were determined at different stages of lactation in three population groups: nonprivileged Ethiopian, privileged Ethiopian, and Swedish mothers [21].
• Numerous studies across several population groups have indicated that insulin resistance plays a central role in the development of type 2 diabetes mellitus (T2DM) [22].
• The differential inducibility of Hsp70/Hsc70 due to variable basal synthesis of Hsp70/Hsc70 and based upon population group may contribute to differential stress tolerance or disease susceptibility [23].
• These patients were drawn from the Black, Coloured, and White population groups and collectively represent 24 mutant alleles underlying the FH phenotype [24].

Anatomical context of Population Groups

• The higher red blood cell thiopurine methyltransferase activity in the Saami population group indicates that these subjects may require higher dosages of thiopurine drugs than Caucasians [25].
• In the cell lines and the population groups, the AluyHJ insertion was most frequently found associated with HLA-A1 or A24, AluyHG with HLA-A2, and AluyHF with HLA-A2, -A10, or -A26 [26].
• Performance of glutaraldehyde-preserved porcine bioprosthesis as a mitral valve substitute in a young population group [27].
• This was promoted by the fact that beta-thalassaemia trait is present in 1-17% of different population groups in India. To study mutagen-induced chromosome instability, G2 lymphocytes were exposed to bleomycin, ara-C or gentian violet in 48-h cultures [28].
• Polymorphisms were recorded from amniotic fluid specimens received from 6,250 patients from 4 major population groups, ie, White (European)-2,334 cases, American Black-1,795 cases, Hispanic descent-1,737 cases, and Asian (Oriental and Indian)-384 cases [29].

Associations of Population Groups with chemical compounds

• Serum total cholesterol level and dietary intake were surveyed 1975--1977 in six Japanese population groups with different lifestyles, including groups in both rural (Akita and Kochi) and urban (Osaka) areas [30].
• A statistically significant correlation was present between nitrate and N-nitrosoproline excretion in the total population group (r = 0.297, P = 0.0001) [31].
• An increase in the urinary excretion of 3-methyladenine and 7-methylguanine was associated with tobacco smoking in the total population group [31].
• The major factor responsible is a deficiency of iron, whith folate deficiency also playing a role in some population groups, especially in preganant women [32].
• These findings warrant food fortification with folic acid in this and similar population groups [33].

Gene context of Population Groups

• BACKGROUND: Although CYP2D6 has been studied extensively in different population groups, relatively little is known for black Americans [34].
• MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry [35].
• This approach allowed extrapolation of the recombinant clearance data to specific population groups and investigation of the role of "minor" forms like CYP3A5 and CYP2C19 in comparison to the most prolific CYP3A4 [36].
• C4A alleles A*4, A*45, A*58, A*12, A*14, A*19 and the C4A*3 A*91 duplication were only found in the San/Khoi population group [37].
• DNA samples of 2303 individuals from nine different population groups were screened for variant -175g-->t in the promoter region of the low-density lipoprotein receptor (LDLR) gene [38].

Analytical, diagnostic and therapeutic context of Population Groups

• HLA-A, -B, -C, -DR, -DQ typing in a population group of Senegal: distribution of HLA antigens and HLA-DRB1*13 and DRB1*11 subtyping by PCR using sequence-specific primers (PCR-SSP) [39].
• A randomized, double-blind study used 24-hour ambulatory blood pressure (BP) monitoring to compare the effects of 2 beta blockers, bisoprolol (10 to 20 mg; n = 107) and atenolol (50 to 100 mg; n = 96), administered once daily in 4 population groups [18].
• When different population groups of tropical Venezuela were evaluated using ELISA based upon Toxocara excretory-secretory antigen (TcESA), solid-phase adsorption of the sera with extracts of a wide variety of non-homologous parasites revealed the existence of significant cross-reactivity [40].
• A simple nonradioactive method of DNA typing for subsets of HLA-DR4: prevalence data on HLA-DR4 subsets in three diabetic population groups [41].
• OBJECTIVE: To characterize the carotenoid content of selected components of the Mediterranean diet commonly eaten by Greek migrants to Melbourne, a population group maintaining a traditional dietary regimen, and who exhibit relatively high circulating carotenoid concentrations and low cardiovascular disease mortality [42].

References