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Chemical Compound Review:

NSC-2097 2-hydroxyhexadecanoic acid

Synonyms: ACMC-1BU0J, AG-D-06168, AG-L-65464, CHEBI:65101, H7021_SIGMA, ...

Moore, K.H. et al., Kuo, T.H. et al., Flavier, A.B. et al., Johnson, D.W. et al., Keleti, G. et al., et al.

Johnson, Trinh,

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Disease relevance of beta-Hydroxypalmitate

Tissue fractionation into mitochondria and cytosol showed that by 2 min of ischemia 44% of beta-hydroxypalmitate and 38% beta-hydroxystearate was located in the cytosol; this percentage increased to greater than 50% by 5 min of ischemia [1].
In contrast to many LPS isolated from Enterobacteriaceae, the dominant component was not beta-hydroxymyristic but beta-hydroxypalmitic acid [2].
Hierarchical autoinduction in Ralstonia solanacearum: control of acyl-homoserine lactone production by a novel autoregulatory system responsive to 3-hydroxypalmitic acid methyl ester [3].

High impact information on beta-Hydroxypalmitate

All three chemical forms of beta-hydroxypalmitate were found in both the mitochondria and the cytosol [1].
There was also a redistribution of BHFA in myocardium of diabetic mice when compared with controls, with a relative decrease in beta-hydroxymyristate and an increase of beta-hydroxypalmitate [4].
A method for the quantification of free 3-hydroxypalmitic acid in plasma by ESI-MS/MS for the diagnosis of long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHAD) is described [5].

Analytical, diagnostic and therapeutic context of beta-Hydroxypalmitate

Reperfusion for 5-10 min dissipated accumulated beta-hydroxypalmitate [6].

References

beta-Hydroxy fatty acid production by ischemic rabbit heart. Moore, K.H., Koen, A.E., Hull, F.E. J. Clin. Invest. (1982) [Pubmed]
Composition and biological properties of lipopolysaccharides isolated from Schizothrix calcicola (Ag.) Gomont (Cyanobacteria). Keleti, G., Sykora, J.L., Lippy, E.C., Shapiro, M.A. Appl. Environ. Microbiol. (1979) [Pubmed]
Hierarchical autoinduction in Ralstonia solanacearum: control of acyl-homoserine lactone production by a novel autoregulatory system responsive to 3-hydroxypalmitic acid methyl ester. Flavier, A.B., Ganova-Raeva, L.M., Schell, M.A., Denny, T.P. J. Bacteriol. (1997) [Pubmed]
Defective oxidative metabolism of heart mitochondria from genetically diabetic mice. Kuo, T.H., Moore, K.H., Giacomelli, F., Wiener, J. Diabetes (1983) [Pubmed]
Analysis of isomeric long-chain hydroxy fatty acids by tandem mass spectrometry: application to the diagnosis of long-chain 3-hydroxyacyl CoA dehydrogenase deficiency. Johnson, D.W., Trinh, M.U. Rapid Commun. Mass Spectrom. (2003) [Pubmed]
Incomplete fatty acid oxidation by ischemic heart: beta-hydroxy fatty acid production. Moore, K.H., Radloff, J.F., Hull, F.E., Sweeley, C.C. Am. J. Physiol. (1980) [Pubmed]

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