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Chemical Compound Review:

LINURON 3-(3,4-dichlorophenyl)-1- methoxy-1-methyl...

Synonyms: Cephalon, Garnitan, Malurane, Profalon, Alfalon, ...

Mazzoleni, G. et al., Rasetti-Escargueil, C. et al., Heading, C.E., Mystakidou, K. et al., Vaverková, S. et al., et al.

Heading, Preti,

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High impact information on LINURON

Two groups received IGF-I (a gift of Cephalon, Inc.) 0.6 mg/kg/d subcutaneously from day 7 to day 16 and the other two groups received placebo injections [1].
The ureic herbicide linuron [3-(3, 4-dichlorophenyl)-1-methoxy-1-methylurea] (CAS 330-55-2) was investigated for genotoxicity in a series of in vivo experiments [2].
An open-label, randomized, single dose, crossover study with a 18 days washout period was conducted in 16 healthy volunteers to compare the pharmacokinetic profile of 20 mg piroxicam freeze-dried tablet (Proxalyoc, Cephalon) with that of 20 mg piroxicam capsule (Feldene, Pfizer) [3].
Oral transmucosal fentanyl citrate (OTFC; brand name Actiq, Cephalon, UT) is a new opioid formulation that incorporates fentanyl into a lozenge and allows drug delivery through the buccal mucosa [4].
DuPont (formerly DuPont Merck), Neurocrine Biosciences and Cephalon are conducting a joint investigation into corticotropin releasingfactor (CRF) ligands [5].

Biological context of LINURON

On the basis of in vivo toxicological long-term tests performed on rodents, the herbicide Linuron [3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea] has been classified by the U.S. Environmental Protection Agency (EPA) (1988) as a class C carcinogen (possibly carcinogenic to humans) [6].

Anatomical context of LINURON

The photoreceptors, or compound eyes, were sessile and located on the dorsal cephalon [7].

Gene context of LINURON

The effect of herbicides on the qualitative properties of healing plants. Part 2: Content and composition of the essential oil from Salvia officinal is L. after application of Afalon 50 WP [8].

Analytical, diagnostic and therapeutic context of LINURON

Vivitrex, an injectable, sustained-release formulation of the opioid antagonist naltrexone, is being developed by Alkermes and Cephalon for the potential once-monthly treatment of alcoholism and opiate use disorder [9].

References

Chronic relapsing experimental autoimmune encephalomyelitis: effects of insulin-like growth factor-I treatment on clinical deficits, lesion severity, glial responses, and blood brain barrier defects. Li, W., Quigley, L., Yao, D.L., Hudson, L.D., Brenner, M., Zhang, B.J., Brocke, S., McFarland, H.F., Webster, H.D. J. Neuropathol. Exp. Neurol. (1998) [Pubmed]
In vivo studies on genotoxicity of pure and commercial linuron. Scassellati-Sforzolini, G., Pasquini, R., Moretti, M., Villarini, M., Fatigoni, C., Dolara, P., Monarca, S., Caderni, G., Kuchenmeister, F., Schmezer, P., Pool-Zobel, B.L. Mutat. Res. (1997) [Pubmed]
Pharmacokinetic profiles of two tablet formulations of piroxicam. Rasetti-Escargueil, C., Grangé, V. International journal of pharmaceutics. (2005) [Pubmed]
Oral transmucosal fentanyl citrate: overview of pharmacological and clinical characteristics. Mystakidou, K., Katsouda, E., Parpa, E., Vlahos, L., Tsiatas, M.L. Drug delivery. (2006) [Pubmed]
CRF antagonists Dupont. Preti, A. Current opinion in investigational drugs (London, England : 2000) (2001) [Pubmed]
Influence of the herbicide Linuron on growth rate and gap-junctional intercellular communication of cultured endothelial cells. Mazzoleni, G., Telò, P., Camplani, A., Tanganelli, S., Monarca, S., Ragnotti, G. J. Environ. Pathol. Toxicol. Oncol. (1994) [Pubmed]
Photoreceptor ultrastructure of the amphipod, Cyamus ceti (Linné, 1758), an ectoparasite of bowhead, right and gray whales. Levin, M.J., Pfeiffer, C.J. J. Submicrosc. Cytol. Pathol. (1999) [Pubmed]
The effect of herbicides on the qualitative properties of healing plants. Part 2: Content and composition of the essential oil from Salvia officinal is L. after application of Afalon 50 WP. Vaverková, S., Hollá, M., Tekel, J. Die Pharmazie. (1995) [Pubmed]
Vivitrex (Alkermes/Cephalon). Heading, C.E. Current opinion in investigational drugs (London, England : 2000) (2006) [Pubmed]

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