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Chemical Compound Review:

N-Bdap N-butylpropane-1,3-diamine

Synonyms: AG-G-69714, NSC-31395, AC1L3UZB, NSC31395, CTK5C9473, ...

Baillon, J.G. et al., Shantz, L.M. et al., Shantz, L.M. et al.

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High impact information on N-Bdap

We have studied the effects of altering these elements on both the expression of AdoMetDC and its regulation by n-butyl-1,3-diaminopropane (BDAP), a spermine synthase inhibitor [1].
Although treatment of COS-7 cells with n-butyl-1,3-diaminopropane greatly increased endogenous AdoMetDC activity, the spermine depletion brought about by this inhibitor did not stimulate AdoMetDC expression from pSAMh1 [2].
Among the compounds described in this paper, the most potent competitive inhibitor of spermine synthase, with respect to spermidine, is N-butyl-1,3-diaminopropane with Ki values of 11.9 nM and 10.4 nM for the HTC cell and bovine spleen enzymes respectively [3].
Inhibition of spermine synthase by this alkylated amine is selective since spermidine synthase activity is not affected up to 100 microM N-butyl-1,3-diaminopropane at a range of 5-200 microM putrescine [3].

References

Role of the 5'-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine. Shantz, L.M., Viswanath, R., Pegg, A.E. Biochem. J. (1994) [Pubmed]
Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content. Shantz, L.M., Holm, I., Jänne, O.A., Pegg, A.E. Biochem. J. (1992) [Pubmed]
Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells. Baillon, J.G., Kolb, M., Mamont, P.S. Eur. J. Biochem. (1989) [Pubmed]

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