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Chemical Compound Review:

Halon-1211 bromo-chloro-difluoro-methane

Synonyms: Daiflon 12B1, Flugex 12B1, CCRIS 5663, Freon 12B1, Halon 1211, ...

Yu, H. et al., Kaufman, J.D. et al., Steadman, C. et al., Wickramaratne, G.A. et al., Smeeton, W.M. et al., et al.

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Disease relevance of bromo-chloro-difluoro-methane

Bromochlorodifluoromethane (halon 1211, a fire extinguisher), like other fluorocarbons, has been linked with ventricular arrhythmias and myocardial depression [1].
Acute Halon (bromochlorodifluoromethane) toxicity by accidental and recreational inhalation [2].
Sudden death resulting from inhalation of fire extinguishers containing bromochlorodifluoromethane [3].

High impact information on bromo-chloro-difluoro-methane

The gas-phase reaction of halon 1211 (CBrClF2) with hydrogen has been studied experimentally at atmospheric pressure in a plug flow, isothermal reactor over the temperature range of 673 to 973 K, at residence times ranging from 0.5 to 2.5 s with an input ratio of N2:H2:halon 1211 of 19:10:1 [4].
Fatal accidental inhalation of bromochlorodifluoromethane (Halon 1211) [5].
Assessment of the reproductive toxicology of bromochlorodifluoromethane (BCF, halon 1211) in the rat [6].

Biological context of bromo-chloro-difluoro-methane

Two cases of abuse of bromochlorodifluoromethane (BCF - a fire-extinguishing agent) by inhalation are reported [7].

References

A study of the cardiac effects of bromochlorodifluoromethane (halon 1211) exposure during exercise. Kaufman, J.D., Morgan, M.S., Marks, M.L., Greene, H.L., Rosenstock, L. Am. J. Ind. Med. (1992) [Pubmed]
Acute Halon (bromochlorodifluoromethane) toxicity by accidental and recreational inhalation. Gerhardt, R.T. The American journal of emergency medicine. (1996) [Pubmed]
Sudden death resulting from inhalation of fire extinguishers containing bromochlorodifluoromethane. Smeeton, W.M., Clark, M.S. Medicine, science, and the law. (1985) [Pubmed]
Experimental and computational studies of the gas-phase reaction of halon 1211 with hydrogen. Yu, H., Kennedy, E.M., Uddin, M.A., Sullivan, S.P., Dlugogorski, B.Z. Environ. Sci. Technol. (2005) [Pubmed]
Fatal accidental inhalation of bromochlorodifluoromethane (Halon 1211). Lerman, Y., Winkler, E., Tirosh, M.S., Danon, Y., Almog, S. Human & experimental toxicology. (1991) [Pubmed]
Assessment of the reproductive toxicology of bromochlorodifluoromethane (BCF, halon 1211) in the rat. Wickramaratne, G.A., Tinston, D.J., Kinsey, D.L., Doe, J.E. British journal of industrial medicine. (1988) [Pubmed]
Abuse of a fire-extinguishing agent and sudden death in adolescents. Steadman, C., Dorrington, L.C., Kay, P., Stephens, H. Med. J. Aust. (1984) [Pubmed]

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