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Chemical Compound Review:

AG-E-47862 phenyl-sulfinyl-methanamine

Synonyms: NSC-227417, LS-27438, CTK4E3535, NSC227417, AKOS006278179, ...

Doerge, D.R. et al., Chieli, E. et al., Cox, D.N. et al.

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High impact information on phenyl-sulfinyl-methanamine

All peroxidases tested catalyzed essentially quantitative oxygen transfer from 18O-labeled hydrogen peroxide into thiobenzamide S-oxide, suggesting that oxygen rebound from the oxoferryl heme is tightly coupled with the initial electron transfer in the active site [1].
[14C]TB was oxidized by microsomes to thiobenzamide S-oxide, benzamide, and covalently bound metabolites [2].
The formation of thiobenzamide-S-oxide (TBSO) from thiobenzamide (TB) by rat liver microsomes was competitively inhibited by methimazole (MMI; 1-methyl-2-mercaptoimidazole), a known substrate and inhibitor of the microsomal FAD-containing monooxygenase [3].

References

Peroxidase-catalyzed S-oxygenation: mechanism of oxygen transfer for lactoperoxidase. Doerge, D.R., Cooray, N.M., Brewster, M.E. Biochemistry (1991) [Pubmed]
The effect of partial hepatectomy on the metabolism, distribution, and nephrotoxicity of para-methylthiobenzamide in the rat. Cox, D.N., Davidson, V.P., Judd, C.E., Stodgell, C., Traiger, G.J. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
Methimazole-induced modulation of thiobenzamide bioactivation and toxicity. Chieli, E., Malvaldi, G. Toxicol. Lett. (1983) [Pubmed]

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