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Chemical Compound Review

Tiobenzamide     benzenecarbothioamide

Synonyms: Benzothiamide, THIOBENZAMIDE, Benzothioamide, AC1LEBNM, PubChem18582, ...
 
 
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Disease relevance of THIOBENZAMIDE

  • The effect of acetone pretreatment (5% in drinking water for 10 days on rat liver metabolism and toxicity of thiobenzamide (TB) was investigated [1].
  • Biliary cirrhosis and tumors induced by chronic administration of thiobenzamide to rats [2].
  • One hundred and fifteen synthesized mono, di, and trihydroxybenzamide and thiobenzamide derivatives having structures related to euglobals were examined for their inhibitory effects on Epstein-Barr virus (EBV) activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) as a primary screening test for anti-tumor-promoters [3].
 

High impact information on THIOBENZAMIDE

  • Hypophysectomy of males reduced liver microsomal N,N-dimethylaniline N-oxidation, thiobenzamide S-oxidation, and imipramine N-oxidation, although the reduction was not as marked with the latter substrate [4].
  • Examination was made to determine whether inhibition by SAM of the development of preneoplastic liver lesions persists to SAM withdrawal in diethylnitrosamine-initiated F344 rats promoted with thiobenzamide (TB) [5].
  • With regard to phase-I pathway, the expression of various P450-like activities (IA1, IA2, IIB1, IIE1, IIIA P450 classes) and thiobenzamide s-oxidase (as FAD-MFO marker), were examined in terms of their exact incubation conditions for the LMA during a period of preincubation (1 h) over the tau range 0.06-1.40 [6].
  • Thiobenzamide and diethyldithiocarbamate were found to be the most effective inhibitors of the ha-P-450j-dependent aniline hydroxylation [7].
  • The rate constants for thiobenzamide oxygenation by LPX/H2O2 were found to correlate with calculated vertical ionization potentials, suggesting rate-limiting single-electron transfer between LPX compound I and the organosulfur substrate [8].
 

Chemical compound and disease context of THIOBENZAMIDE

 

Biological context of THIOBENZAMIDE

 

Anatomical context of THIOBENZAMIDE

 

Associations of THIOBENZAMIDE with other chemical compounds

 

Gene context of THIOBENZAMIDE

 

Analytical, diagnostic and therapeutic context of THIOBENZAMIDE

References

  1. Possible role of the acetone-inducible cytochrome P-450IIE1 in the metabolism and hepatotoxicity of thiobenzamide. Chieli, E., Saviozzi, M., Puccini, P., Longo, V., Gervasi, P.G. Arch. Toxicol. (1990) [Pubmed]
  2. Biliary cirrhosis and tumors induced by chronic administration of thiobenzamide to rats. Malvaldi, G., Chieli, E., Saviozzi, M. Arch. Toxicol. (1984) [Pubmed]
  3. Inhibitors of skin-tumor promotion. XIII. Inhibitory effects of euglobals and their related compounds on Epstein-Barr virus activation and on two-stage carcinogenesis of mouse skin tumors. (2). Takasaki, M., Konoshima, T., Kozuka, M., Yoneyama, K., Yoshida, S., Tokuda, H., Nishino, H., Iwashima, A. Biol. Pharm. Bull. (1995) [Pubmed]
  4. Hormonal regulation of microsomal flavin-containing monooxygenase: tissue-dependent expression and substrate specificity. Lemoine, A., Williams, D.E., Cresteil, T., Leroux, J.P. Mol. Pharmacol. (1991) [Pubmed]
  5. Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats. Simile, M.M., Saviozzi, M., De Miglio, M.R., Muroni, M.R., Nufris, A., Pascale, R.M., Malvaldi, G., Feo, F. Carcinogenesis (1996) [Pubmed]
  6. Strategies for advancement of short-term mutagenicity tests: on the optimal ionic strength for the liver microsomal assay. Paolini, M., Mesirca, R., Pozzetti, L., Silingardi, P., Grilli, S., Cantelli-Forti, G. Carcinogenesis (1992) [Pubmed]
  7. Purification and characterization of an acetone-inducible cytochrome P-450 from hamster liver microsomes. Puccini, P., Menicagli, S., Longo, V., Santucci, A., Gervasi, P.G. Biochem. J. (1992) [Pubmed]
  8. Peroxidase-catalyzed S-oxygenation: mechanism of oxygen transfer for lactoperoxidase. Doerge, D.R., Cooray, N.M., Brewster, M.E. Biochemistry (1991) [Pubmed]
  9. Methimazole-induced modulation of thiobenzamide bioactivation and toxicity. Chieli, E., Malvaldi, G. Toxicol. Lett. (1983) [Pubmed]
  10. Placental peroxidase--further purification of the enzyme and oxidation of thiobenzamide. Joseph, P., Srinivasan, N.S., Kulkarni, A.P. Placenta (1993) [Pubmed]
  11. Thiobenzamide-induced hepatotoxicity: effects of substituents and route of administration on the nature and extent of liver injury. Grossman, S.J., Patrick, D.H., Kornbrust, D., Smith, P.F., Herold, E.G., DeLuca, J.G., Zacchei, A.G. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  12. Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine. Yu, K.L., Torri, A.F., Luo, G., Cianci, C., Grant-Young, K., Danetz, S., Tiley, L., Krystal, M., Meanwell, N.A. Bioorg. Med. Chem. Lett. (2002) [Pubmed]
  13. Rat liver flavin-containing monooxygenase (FMO): cDNA cloning and expression in yeast. Itoh, K., Kimura, T., Yokoi, T., Itoh, S., Kamataki, T. Biochim. Biophys. Acta (1993) [Pubmed]
  14. Oxidation of thiobenzamide by the FAD-containing and cytochrome P-450-dependent monooxygenases of liver and lung microsomes. Tynes, R.E., Hodgson, E. Biochem. Pharmacol. (1983) [Pubmed]
  15. Liver cell proliferation induced by single administration of thiobenzamide. Malvaldi, G., Chieli, E., Pollera, M. Toxicol. Lett. (1982) [Pubmed]
  16. Effects of thiobenzamide on the rat immune system. Pasquinelli, P., Vaglini, F., Pieracci, D., Ettorre, V., Puccini, M., Malvaldi, G. International journal of tissue reactions. (1989) [Pubmed]
  17. Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Chiba, K., Kubota, E., Miyakawa, T., Kato, Y., Ishizaki, T. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  18. The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans. Rodrigues, A.D., Ferrero, J.L., Amann, M.T., Rotert, G.A., Cepa, S.P., Surber, B.W., Machinist, J.M., Tich, N.R., Sullivan, J.P., Garvey, D.S. Drug Metab. Dispos. (1994) [Pubmed]
  19. Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5. Cherrington, N.J., Cao, Y., Cherrington, J.W., Rose, R.L., Hodgson, E. Xenobiotica (1998) [Pubmed]
  20. Nephrotoxicity of para-substituted thiobenzamide derivatives in the rat. Traiger, G.J., Gammal, L.M., Cox, D.N., Haschek, W.M. Toxicology (1989) [Pubmed]
  21. Regio- and stereoselective oxygenations by adult human liver flavin-containing monooxygenase 3. Comparison with forms 1 and 2. Lomri, N., Yang, Z., Cashman, J.R. Chem. Res. Toxicol. (1993) [Pubmed]
  22. Involvement of reactive oxygen species in the microsomal S-oxidation of thiobenzamide. Younes, M. Experientia (1985) [Pubmed]
 
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