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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MED6  -  mediator complex subunit 6

Homo sapiens

Synonyms: ARC33, Activator-recruited cofactor 33 kDa component, Mediator complex subunit 6, Mediator of RNA polymerase II transcription subunit 6, NY-REN-28, ...
 
 
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High impact information on MED6

  • A database search revealed the existence of MED6-related genes in humans and Caenorhabditis elegans, suggesting that the role of mediator in transcriptional activation is conserved throughout the evolution [1].
  • We also showed that LET-19 and DPY-22 form a complex in vivo with other components of Mediator, SUR-2/MED23 and LET-425/MED6 [2].
  • Two potential subcomplexes were additionally observed: a 1-MDa complex from the CDK8-cell line (TMLC2) and a 600-kDa complex from the MED6-cell line (TMLC3) [3].
 

Anatomical context of MED6

  • To further understand the structural and functional diversity of these complexes we established three HeLa cell lines each expressing one of three epitope-tagged human TRAP/Mediator subunits, MED6, MED7, and CDK8 and isolated the complexes in which these subunits were contained by affinity and HPLC-gel filtration chromatography [3].

References

  1. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. Lee, Y.C., Min, S., Gim, B.S., Kim, Y.J. Mol. Cell. Biol. (1997) [Pubmed]
  2. Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Yoda, A., Kouike, H., Okano, H., Sawa, H. Development (2005) [Pubmed]
  3. A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation. Furumoto, T., Tanaka, A., Ito, M., Malik, S., Hirose, Y., Hanaoka, F., Ohkuma, Y. Genes Cells (2007) [Pubmed]
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