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Gene Review

MED6  -  mediator complex subunit 6

Homo sapiens

Synonyms: ARC33, Activator-recruited cofactor 33 kDa component, Mediator complex subunit 6, Mediator of RNA polymerase II transcription subunit 6, NY-REN-28, ...
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High impact information on MED6

  • A database search revealed the existence of MED6-related genes in humans and Caenorhabditis elegans, suggesting that the role of mediator in transcriptional activation is conserved throughout the evolution [1].
  • We also showed that LET-19 and DPY-22 form a complex in vivo with other components of Mediator, SUR-2/MED23 and LET-425/MED6 [2].
  • Two potential subcomplexes were additionally observed: a 1-MDa complex from the CDK8-cell line (TMLC2) and a 600-kDa complex from the MED6-cell line (TMLC3) [3].

Anatomical context of MED6

  • To further understand the structural and functional diversity of these complexes we established three HeLa cell lines each expressing one of three epitope-tagged human TRAP/Mediator subunits, MED6, MED7, and CDK8 and isolated the complexes in which these subunits were contained by affinity and HPLC-gel filtration chromatography [3].


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