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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SH2B3  -  SH2B adaptor protein 3

Homo sapiens

Synonyms: IDDM20, LNK, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, SH2B adapter protein 3, ...
 
 
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High impact information on SH2B3

  • Finally, we performed allele-specific quantitative polymerase chain reaction to demonstrate that cis-regulatory variation in the lymphocyte adaptor protein (SH2B adapter protein 3) contributes to differential expression between European and African samples [1].
  • The B lymphocyte adaptor molecule of 32 kDa (Bam32) is an adaptor that plays an indispensable role in BCR signaling [2].
  • We determined that the differential promoter usage by NK cells appears to be susceptible to perturbation, as both the murine NK cell line LNK, as well as cultured C57BL/6 NK cells showed altered promoter usage relative to fresh NK cells [3].
  • Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells [4].

References

  1. Gene-expression variation within and among human populations. Storey, J.D., Madeoy, J., Strout, J.L., Wurfel, M., Ronald, J., Akey, J.M. Am. J. Hum. Genet. (2007) [Pubmed]
  2. The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. Niiro, H., Allam, A., Stoddart, A., Brodsky, F.M., Marshall, A.J., Clark, E.A. J. Immunol. (2004) [Pubmed]
  3. Transcriptional control of murine CD94 gene: differential usage of dual promoters by lymphoid cell types. Wilhelm, B.T., Landry, J.R., Takei, F., Mager, D.L. J. Immunol. (2003) [Pubmed]
  4. Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells. Boulday, G., Coulon, F., Fraser, C.C., Soulillou, J.P., Charreau, B. Transplantation (2002) [Pubmed]
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