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Gene Review

Zfand2a  -  zinc finger, AN1-type domain 2A

Mus musculus

Synonyms: AA407930, AN1-type zinc finger protein 2A, AU016206, Airap, Arsenite-inducible RNA-associated protein
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Disease relevance of Zfand2a


High impact information on Zfand2a

  • AIRAP's association with the 19S cap reverses the stabilizing affect of ATP on the 26S proteasome during particle purification, and AIRAP-containing proteasomes, though constituted of 19S and 20S subunits, acquire features of hybrid proteasomes with both 19S and 11S regulatory caps [2].
  • Compared to the wild-type, knockout mouse cells or C. elegans lacking AIRAP accumulate more polyubiquitylated proteins and exhibit higher levels of stress when exposed to arsenite, and proteasomes isolated from arsenite-treated AIRAP knockout cells are relatively impaired in substrate degradation in vitro [2].
  • Protein misfolding caused by exposure to arsenite is associated with transcriptional activation of the AIRAP gene [2].
  • Immunochemistry and cell fractionation experiments indicate that, when induced, AIRAP is present in both the nucleus and the cytoplasm, and cross-linking experiments indicate that it associates with RNA in vivo [1].
  • The expression of a C elegans homologue of AIRAP, aip-1, is also induced by exposure to arsenite, and expression of an aip-1::gfp transgene is most pronounced in hypodermal cells [1].


  1. Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity. Sok, J., Calfon, M., Lu, J., Lichtlen, P., Clark, S.G., Ron, D. Cell Stress Chaperones (2001) [Pubmed]
  2. An Arsenite-Inducible 19S Regulatory Particle-Associated Protein Adapts Proteasomes to Proteotoxicity. Stanhill, A., Haynes, C.M., Zhang, Y., Min, G., Steele, M.C., Kalinina, J., Martinez, E., Pickart, C.M., Kong, X.P., Ron, D. Mol. Cell (2006) [Pubmed]
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