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Gene Review

SCAMP3  -  secretory carrier membrane protein 3

Homo sapiens

Synonyms: C1orf3, PROPIN1, Secretory carrier membrane protein 3, Secretory carrier-associated membrane protein 3
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High impact information on SCAMP3

  • The second gene, propin1, has a 1.5-kb cDNA and shares homology to a rat secretory carrier membrane protein 37 (SCAMP37) [1].
  • EGF catalyzes the progressive phosphorylation of the SCAMPs up to 1 h poststimulation and may enhance colocalization of the EGFR and SCAMP3 within the cell interior [2].
  • Phosphorylation is reversible after vanadate washout in situ or when isolated SCAMP3 is incubated with the recombinant tyrosine phosphatase PTP1B [2].
  • Mutational analysis of all 37 positional candidate genes revealed sequence variations in 3 different genes, AK000210, CCT3, and SCAMP3, that were segregating in each affected kindred and were not found in 96 healthy individuals, indicating, that a single responsible gene causing MCKD1 remains elusive [3].

Anatomical context of SCAMP3


Associations of SCAMP3 with chemical compounds

  • Vanadate also causes the partial accumulation of SCAMP3, but not SCAMP1, in "patches" at or near the cell surface [2].


  1. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. Winfield, S.L., Tayebi, N., Martin, B.M., Ginns, E.I., Sidransky, E. Genome Res. (1997) [Pubmed]
  2. Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor. Wu, T.T., Castle, J.D. Mol. Biol. Cell (1998) [Pubmed]
  3. Medullary cystic kidney disease type 1: mutational analysis in 37 genes based on haplotype sharing. Wolf, M.T., Mucha, B.E., Hennies, H.C., Attanasio, M., Panther, F., Zalewski, I., Karle, S.M., Otto, E.A., Deltas, C.C., Fuchshuber, A., Hildebrandt, F. Hum. Genet. (2006) [Pubmed]
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