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Gene Review

Ptpn1  -  protein tyrosine phosphatase, non-receptor...

Rattus norvegicus

Synonyms: PTP-1B, Protein-tyrosine phosphatase 1B, Tyrosine-protein phosphatase non-receptor type 1
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Disease relevance of Ptpn1


High impact information on Ptpn1


Biological context of Ptpn1


Anatomical context of Ptpn1


Associations of Ptpn1 with chemical compounds


Enzymatic interactions of Ptpn1

  • Analysis of the catalytic activity of partially purified rat adipocyte PTP-alpha and LAR and recombinant PTP-1B showed that all three PTPases dephosphorylate IR [13].

Regulatory relationships of Ptpn1


Other interactions of Ptpn1

  • Protein tyrosine phosphatase 1B (PTP1B) acts as a physiological negative regulator of insulin signaling by dephosphorylating the activated insulin receptor (IR) [9].
  • SHP2 (P < 0.03) and PTP1B (P < 0.03) increased only in SM/SP with no change in PTEN in CM/SP and SM/SP groups [14].
  • RSG treatment in normal rats did not significantly change PTP1B activities and levels or protein levels of IRbeta, IRS-1, and -2 in diabetic rats [9].
  • Rat fibroblasts lacking PTP1B expression do not activate Src or Rac in response to insulin and cannot reorganize actin [7].
  • PTP1B glutathionylation was dependent on H(2)O(2) as the presence of catalase at the time of ADP stimulation inhibited the formation of the conjugate [12].

Analytical, diagnostic and therapeutic context of Ptpn1

  • PTP1B protein levels, as determined by Western blot, were significantly higher in mediobasal hypothalamic punches collected from 20-wk-old rats, compared with 8-wk-old rats (P < 0.05) [8].
  • There was no change in the activity or expression of PTP1B in APS-treated normal rats, and blood insulin levels did not change in TIIDM rats after treatment with APS [15].
  • Quantitative PCR analysis showed that PTP1B and PTPL1 were induced approximately 30-fold and approximately 60-fold, respectively, by 2 weeks after injury in the damaged vessels compared with the uninjured vessels [16].
  • The purpose of this study was to investigate the effect of changes in transpulmonary pressure (Ptp) and induced constriction on parenchymal bulk (k) and shear (mu) moduli [17].
  • With increasing body size, the transpleural hydraulic pressure gradient (Ptp = Pepl - Pliq) at the level of the right atrium increased from 1.45 to 5.6 cmH2O going from rats to sheep [18].


  1. Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression. Shimizu, S., Ugi, S., Maegawa, H., Egawa, K., Nishio, Y., Yoshizaki, T., Shi, K., Nagai, Y., Morino, K., Nemoto, K., Nakamura, T., Bryer-Ash, M., Kashiwagi, A. J. Biol. Chem. (2003) [Pubmed]
  2. Maternal food restriction enhances insulin-induced GLUT-4 translocation and insulin signaling pathway in skeletal muscle from suckling rats. Gavete, M.L., Martín, M.A., Alvarez, C., Escrivá, F. Endocrinology (2005) [Pubmed]
  3. Static volume-pressure relationship in normal rats at various stages of growth. Sahebjami, H., Vassallo, C.L. Respiration physiology. (1979) [Pubmed]
  4. Toxic oxygen metabolites induce vasoconstriction and bronchoconstriction in isolated, plasma-perfused rat lungs. Kjaeve, J., Vaage, J., Bjertnaes, L. Acta anaesthesiologica Scandinavica. (1991) [Pubmed]
  5. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Liu, F., Sells, M.A., Chernoff, J. Mol. Cell. Biol. (1998) [Pubmed]
  6. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phosphorylated caveolin. Swaney, J.S., Patel, H.H., Yokoyama, U., Head, B.P., Roth, D.M., Insel, P.A. J. Biol. Chem. (2006) [Pubmed]
  7. Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. Dadke, S., Chernoff, J. J. Biol. Chem. (2003) [Pubmed]
  8. Increased Hypothalamic Protein Tyrosine Phosphatase 1B Contributes to Leptin Resistance with Age. Morrison, C.D., White, C.L., Wang, Z., Lee, S.Y., Lawrence, D.S., Cefalu, W.T., Zhang, Z.Y., Gettys, T.W. Endocrinology (2007) [Pubmed]
  9. Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats. Wu, Y., Ouyang, J.P., Wu, K., Wang, S.S., Wen, C.Y., Xia, Z.Y. Br. J. Pharmacol. (2005) [Pubmed]
  10. Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats. Hirata, A.E., Alvarez-Rojas, F., Carvalheira, J.B., Carvalho, C.R., Dolnikoff, M.S., Abdalla Saad, M.J. Life Sci. (2003) [Pubmed]
  11. Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes. Tang, S., Le-Tien, H., Goldstein, B.J., Shin, P., Lai, R., Fantus, I.G. Diabetes (2001) [Pubmed]
  12. Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B. Rinna, A., Torres, M., Forman, H.J. Free Radic. Biol. Med. (2006) [Pubmed]
  13. Dynamics of protein-tyrosine phosphatases in rat adipocytes. Calera, M.R., Vallega, G., Pilch, P.F. J. Biol. Chem. (2000) [Pubmed]
  14. Perturbed skeletal muscle insulin signaling in the adult female intrauterine growth-restricted rat. Oak, S.A., Tran, C., Pan, G., Thamotharan, M., Devaskar, S.U. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  15. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Wu, Y., Ou-Yang, J.P., Wu, K., Wang, Y., Zhou, Y.F., Wen, C.Y. Acta Pharmacol. Sin. (2005) [Pubmed]
  16. Protein-tyrosine phosphatases in the vessel wall: differential expression after acute arterial injury. Wright, M.B., Seifert, R.A., Bowen-Pope, D.F. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  17. Elastic moduli of excised constricted rat lungs. Salerno, F.G., Ludwig, M.S. J. Appl. Physiol. (1999) [Pubmed]
  18. Size-related differences in parietal extrapleural and pleural liquid pressure distribution. Negrini, D., Miserocchi, G. J. Appl. Physiol. (1989) [Pubmed]
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