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Gene Review

Pds5b  -  PDS5, regulator of cohesion maintenance,...

Mus musculus

Synonyms: AI646570, AS3, AW212954, Androgen-induced proliferation inhibitor, Androgen-induced prostate proliferative shutoff-associated protein AS3, ...
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High impact information on Aprin

  • Treatment of cells with either concentration of the sense, AS1, AS2, or 20 microM AS3 oligonucleotides had little effect on either Oil Red O lipid accumulation or induction of p107 protein levels [1].
  • In addition, treatment with AS3 led to a significant inhibition of cellular proliferation associated with clonal expansion [1].
  • A series of three phosphorothioate oligonucleotides in antisense orientation was generated, designated AS1, AS2, and AS3 along with a sense control oligonucleotide complementary to AS1 and added to postconfluent cells at a concentration of 20 and 50 microM throughout hormonally stimulated differentiation [1].
  • The two cell lines Lev 1-3 and AS3, which secrete monoclonal anti-levan antibody and express surface membrane immunoglobulins that are capable of binding the levan, were cultured for 24 h or 48 h with levan of various molecular weights (5 x 10(4), 2 x 10(5) or 2 x 10(7) daltons) [2].


  1. Antisense suppression of p107 inhibits 3T3-L1 adipocyte differentiation. May, J.S., Prince, A.M., Lyle, R.E., McGehee, R.E. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Cross-linking of surface immunoglobulins and endocytosis of antigen are not sufficient to suppress antibody production of two hybridoma cell lines. Goud, B., Legrain, P., Antoine, J.C., Avrameas, S., Buttin, G. J. Recept. Res. (1981) [Pubmed]
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