Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MPHOSPH10 - M-phase phosphoprotein 10 (U3 small...

Homo sapiens

Synonyms: CT90, M phase phosphoprotein 10, MPP10, MPP10P, PPP1R106, ...

Westendorf, J.M. et al.

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High impact information on MPHOSPH10

In early to middle M phase of the cell cycle, MPP10 colocalized with fibrillarin to chromosome surfaces [1].
When nucleoli were separated into fibrillar and granular domains by treatment with actinomycin D, almost all the MPP10 was found in the fibrillar caps, which contain proteins involved in rRNA processing [1].
At telophase, MPP10 was found in cellular structures that resembled nucleolus-derived bodies and prenucleolar bodies [1].

Other interactions of MPHOSPH10

Some of these bodies lacked fibrillarin, a previously described component of nucleolus-derived bodies and prenucleolar bodies, however, and the bulk of MPP10 arrived at the nucleolus later than fibrillarin [1].

Analytical, diagnostic and therapeutic context of MPHOSPH10

We show that by cell fractionation, almost all MPP10 was found in isolated nucleoli [1].

References

M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. Westendorf, J.M., Konstantinov, K.N., Wormsley, S., Shu, M.D., Matsumoto-Taniura, N., Pirollet, F., Klier, F.G., Gerace, L., Baserga, S.J. Mol. Biol. Cell (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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