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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cellular Structures

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Disease relevance of Cellular Structures

  • Recent histological studies have shown that neuroblastomas can present with a schwannian cell component, rich in S100 protein [1].
  • In addition, we show that vaccinia virus-specific CD8+ Th cell function is mediated through production of lymphokines, including IL-2, and that the CD8+ Th cell component in the CTL response is labile, decreasing progressively with increasing time after in vivo priming [2].
  • In myxoid liposarcomas, p53 alterations are not relevant to the presence or absence of round cell components [3].
  • Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis [4].
  • However, keratin IFs were soon identified as major cellular structures to be affected in a variety of chronic liver diseases, such as alcoholic and non-alcoholic steatohepatitis (ASH, NASH), copper toxicosis, and cholestasis [5].

High impact information on Cellular Structures


Chemical compound and disease context of Cellular Structures


Biological context of Cellular Structures


Anatomical context of Cellular Structures

  • It formed a stratified cellular structure with ultrastructural characteristics of a fully differentiated stratified squamous epithelium when cultured in equal parts of Dulbecco's modified Eagle medium and Ham's medium F12, supplemented only with insulin, transferrin, and selenium [20].
  • Obscurin is a giant sarcomeric protein of approximately 800 kD that binds to titin and has been proposed to mediate interactions between myofibrils and other cellular structures [21].
  • Indeed, we have found that RhoE in farnesylated in vivo and that this modification is required for association with the plasma membrane and with an unidentified cellular structure that may play a role in adhesion [22].
  • The cellular structures were well preserved, including mitochondria and intercalated disks in diazoxide-treated hearts compared with nontreated Ca2+ PD hearts [23].
  • The results directly demonstrate that the Yaa-mediated disease requires alphabeta+ T cells that are not, in themselves, abnormal in either composition or properties, but are engaged by a Yaa-encoded abnormality in a non-T cell component [24].

Associations of Cellular Structures with chemical compounds


Gene context of Cellular Structures

  • We show that a key factor is the presence of another keratin, K15, which was hitherto unappreciated as a basal cell component [30].
  • To understand the site and mechanism of dynamin action, the cellular structures devoted to ECM degradation were analyzed by correlative confocal light-electron microscopy [31].
  • Immunoreactive urocortin was also detected in luteinized granulosa and thecal cells of functioning corpora lutea, in which both cell components are capable of producing steroids [32].
  • BACKGROUND: Platelets are potential contributors to glomerular injury via the release of chemotactic and/or mitogenic mediators upon activation or through direct CD154/CD40-dependent interaction with cell components of the glomerulus [33].
  • The spindle cell component tissue showed coexpression of CD34, c-kit (CD117) and bcl-2 [34].

Analytical, diagnostic and therapeutic context of Cellular Structures


  1. Schwannian cell differentiation of human neuroblastoma cell lines in vitro induced by bromodeoxyuridine. Sugimoto, T., Kato, T., Sawada, T., Horii, Y., Kemshead, J.T., Hino, T., Morioka, H., Hosoi, H. Cancer Res. (1988) [Pubmed]
  2. Role of lymphokine-secreting CD8+ T cells in cytotoxic T lymphocyte responses against vaccinia virus. Mizuochi, T., Hügin, A.W., Morse, H.C., Singer, A., Buller, R.M. J. Immunol. (1989) [Pubmed]
  3. Prognostic relevance of p53 alterations and Mib-1 proliferation index in subgroups of primary liposarcomas. Schneider-Stock, R., Ziegeler, A., Haeckel, C., Franke, D.S., Rys, J., Roessner, A. Clin. Cancer Res. (1999) [Pubmed]
  4. Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis. Oda, Y., Yamamoto, H., Takahira, T., Kobayashi, C., Kawaguchi, K., Tateishi, N., Nozuka, Y., Tamiya, S., Tanaka, K., Matsuda, S., Yokoyama, R., Iwamoto, Y., Tsuneyoshi, M. J. Pathol. (2005) [Pubmed]
  5. The keratin cytoskeleton in liver diseases. Zatloukal, K., Stumptner, C., Fuchsbichler, A., Fickert, P., Lackner, C., Trauner, M., Denk, H. J. Pathol. (2004) [Pubmed]
  6. Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Hoppe, T., Cassata, G., Barral, J.M., Springer, W., Hutagalung, A.H., Epstein, H.F., Baumeister, R. Cell (2004) [Pubmed]
  7. The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis. Finley, D., Bartel, B., Varshavsky, A. Nature (1989) [Pubmed]
  8. Cytoarchitecture and the patterning of fushi tarazu expression in the Drosophila blastoderm. Edgar, B.A., Odell, G.M., Schubiger, G. Genes Dev. (1987) [Pubmed]
  9. Cytokinesis in prokaryotes and eukaryotes: common principles and different solutions. Nanninga, N. Microbiol. Mol. Biol. Rev. (2001) [Pubmed]
  10. BAF: roles in chromatin, nuclear structure and retrovirus integration. Segura-Totten, M., Wilson, K.L. Trends Cell Biol. (2004) [Pubmed]
  11. Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-alpha, IL-1, and RANKL. Suda, K., Woo, J.T., Takami, M., Sexton, P.M., Nagai, K. J. Cell. Physiol. (2002) [Pubmed]
  12. The transmembrane electrical potential in Rhodopseudomonas sphaeroides determined from the distribution of tetraphenylphosphonium after correction for its binding to cell components. Lolkema, J.S., Abbing, A., Hellingwerf, K.J., Konings, W.N. Eur. J. Biochem. (1983) [Pubmed]
  13. Imaging of RNA in situ hybridization by atomic force microscopy. Kalle, W.H., Macville, M.V., van de Corput, M.P., de Grooth, B.G., Tanke, H.J., Raap, A.K. Journal of microscopy. (1996) [Pubmed]
  14. Separation of viable Rickettsia typhi from yolk sac and L cell host components by renografin density gradient centrifugation. Weiss, E., Coolbaugh, J.C., Williams, J.C. Applied microbiology. (1975) [Pubmed]
  15. Identification of a 52-kD calmodulin-binding protein associated with the mitotic spindle apparatus in mammalian cells. Brady, R.C., Cabral, F., Dedman, J.R. J. Cell Biol. (1986) [Pubmed]
  16. Regulation of cytoskeletal proteins involved in cell contact formation during differentiation of granulosa cells on extracellular matrix. Ben-Ze'ev, A., Amsterdam, A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  17. Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man. Adrain, C., Creagh, E.M., Cullen, S.P., Martin, S.J. J. Biol. Chem. (2004) [Pubmed]
  18. M phase phosphoprotein 10 is a human U3 small nucleolar ribonucleoprotein component. Westendorf, J.M., Konstantinov, K.N., Wormsley, S., Shu, M.D., Matsumoto-Taniura, N., Pirollet, F., Klier, F.G., Gerace, L., Baserga, S.J. Mol. Biol. Cell (1998) [Pubmed]
  19. Characterization of a novel chronic photothrombotic ring stroke model in rats by magnetic resonance imaging, biochemical imaging, and histology. Hilger, T., Blunk, J.A., Hoehn, M., Mies, G., Wester, P. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  20. Modulation of the terminal differentiation of human squamous carcinoma cells in vitro by all-trans-retinoic acid. Reiss, M., Pitman, S.W., Sartorelli, A.C. J. Natl. Cancer Inst. (1985) [Pubmed]
  21. Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. Bagnato, P., Barone, V., Giacomello, E., Rossi, D., Sorrentino, V. J. Cell Biol. (2003) [Pubmed]
  22. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Foster, R., Hu, K.Q., Lu, Y., Nolan, K.M., Thissen, J., Settleman, J. Mol. Cell. Biol. (1996) [Pubmed]
  23. Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium. Wang, Y., Ashraf, M. Circ. Res. (1999) [Pubmed]
  24. The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus. Lawson, B.R., Koundouris, S.I., Barnhouse, M., Dummer, W., Baccala, R., Kono, D.H., Theofilopoulos, A.N. J. Immunol. (2001) [Pubmed]
  25. Activation of adenylate cyclase by cholera toxin in rat liver homogenates. Flores, J., Witkum, P., Sharp, G.W. J. Clin. Invest. (1976) [Pubmed]
  26. Myosin subfragment binding for the localization of actin-like microfilaments in cultured cells. A light and electron microscope study. Schloss, J.A., Milsted, A., Goldman, R.D. J. Cell Biol. (1977) [Pubmed]
  27. Alpha-actinin-containing aggregates in transformed cells are highly dynamic structures. Stickel, S.K., Wang, Y.L. J. Cell Biol. (1987) [Pubmed]
  28. Exchangeability of alpha-actinin in living cardiac fibroblasts and muscle cells. McKenna, N.M., Meigs, J.B., Wang, Y.L. J. Cell Biol. (1985) [Pubmed]
  29. Disruption of the FATB gene in Arabidopsis demonstrates an essential role of saturated fatty acids in plant growth. Bonaventure, G., Salas, J.J., Pollard, M.R., Ohlrogge, J.B. Plant Cell (2003) [Pubmed]
  30. The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. Lloyd, C., Yu, Q.C., Cheng, J., Turksen, K., Degenstein, L., Hutton, E., Fuchs, E. J. Cell Biol. (1995) [Pubmed]
  31. Dynamin participates in focal extracellular matrix degradation by invasive cells. Baldassarre, M., Pompeo, A., Beznoussenko, G., Castaldi, C., Cortellino, S., McNiven, M.A., Luini, A., Buccione, R. Mol. Biol. Cell (2003) [Pubmed]
  32. Urocortin and corticotropin-releasing factor receptor expression in normal cycling human ovaries. Muramatsu, Y., Sugino, N., Suzuki, T., Totsune, K., Takahashi, K., Tashiro, A., Hongo, M., Oki, Y., Sasano, H. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  33. Activation of mesangial cells by platelets in systemic lupus erythematosus via a CD154-dependent induction of CD40. Delmas, Y., Viallard, J.F., Solanilla, A., Villeneuve, J., Pasquet, J.M., Belloc, F., Dubus, I., Déchanet-Merville, J., Merville, P., Blanco, P., Pellegrin, J.L., Nurden, A.T., Combe, C., Ripoche, J. Kidney Int. (2005) [Pubmed]
  34. Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117). Pauser, U., da Silva, M.T., Placke, J., Klimstra, D.S., Klöppel, G. Mod. Pathol. (2005) [Pubmed]
  35. Characterization of rat transferrin receptor cDNA: the regulation of transferrin receptor mRNA in testes and in Sertoli cells in culture. Roberts, K.P., Griswold, M.D. Mol. Endocrinol. (1990) [Pubmed]
  36. Expression of centrin isoforms in the mammalian retina. Wolfrum, U., Salisbury, J.L. Exp. Cell Res. (1998) [Pubmed]
  37. Unusual lectin-binding properties of a herpes simplex virus type 1-specific glycoprotein. Olofsson, S., Jeansson, S., Lycke, E. J. Virol. (1981) [Pubmed]
  38. Constitutive steroidogenesis in the R2C Leydig tumor cell line is maintained by the adenosine 3',5'-cyclic monophosphate-independent production of a cycloheximide-sensitive factor that enhances mitochondrial pregnenolone biosynthesis. Freeman, D.A. Endocrinology (1987) [Pubmed]
  39. Ectopic hamartomatous thymoma. A distinctive benign lesion of lower neck. Rosai, J., Limas, C., Husband, E.M. Am. J. Surg. Pathol. (1984) [Pubmed]
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