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Gene Review

CALCOCO2  -  calcium binding and coiled-coil domain 2

Homo sapiens

Synonyms: Antigen nuclear dot 52 kDa protein, Calcium-binding and coiled-coil domain-containing protein 2, MGC17318, NDP52, Nuclear domain 10 protein 52, ...
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Disease relevance of CALCOCO2


High impact information on CALCOCO2

  • NDP52 homodimerization but no heterodimerization with Sp100 or PML could be demonstrated [2].
  • The role of this nuclear domain (which also harbors the Sp100 autoantigen and the NDP52 protein) is unknown [3].
  • Moreover, an immunofluorescent staining assay indicated that NDP52 colocalizes with HCAP1 in the cytoplasm [4].
  • By deletion analysis, the leucine zipper domain of HCAP1 and the zinc finger domain of NDP52 were identified as important regions responsible for the interaction [4].
  • The cloning of full-length cDNA for the BC8 clone and its DNA sequences showed that the BC8 clone is a bovine nuclear domain protein homologous to the human NDP52 gene [5].

Co-localisations of CALCOCO2

  • Furthermore, we show that NDP52 colocalizes with the ND10 protein PML and can be redistributed upon viral infection and interferon treatment [6].


  1. The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1. Korioth, F., Maul, G.G., Plachter, B., Stamminger, T., Frey, J. Exp. Cell Res. (1996) [Pubmed]
  2. Cellular localization, expression, and structure of the nuclear dot protein 52. Sternsdorf, T., Jensen, K., Züchner, D., Will, H. J. Cell Biol. (1997) [Pubmed]
  3. Induction of the PML protein by interferons in normal and APL cells. Chelbi-Alix, M.K., Pelicano, L., Quignon, F., Koken, M.H., Venturini, L., Stadler, M., Pavlovic, J., Degos, L., de Thé, H. Leukemia (1995) [Pubmed]
  4. HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins. Di, Y., Li, J., Zhang, Y., He, X., Lu, H., Xu, D., Ling, J., Huo, K., Wan, D., Li, Y.Y., Gu, J. J. Biochem. (2003) [Pubmed]
  5. Characterization of differentially expressed genes in the bovine T lymphoma cell line. Onodera, H., Ishiguro, N., Horiuchi, M., Shinagawa, M. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  6. Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment. Korioth, F., Gieffers, C., Maul, G.G., Frey, J. J. Cell Biol. (1995) [Pubmed]
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