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RNGTT  -  RNA guanylyltransferase and 5'-phosphatase

Homo sapiens

Synonyms: CAP1A, HCAP1, HCE, HCE1, hCAP, ...
 
 
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Disease relevance of RNGTT

  • EGF at 10 ng/ml, increases the fraction of proliferating cells, induces cellular hypertrophy, reduces stratification and the fraction of differentiating cells in HCE colonies [1].
  • Colon carcinomas expressed slightly higher levels of HCE-1 and HCE-2 than the adjacent normal tissues, whereas the opposite was true with HCE-3 [2].
  • RESULTS: The chemotactic activity induced by HCE and keratocytes after MP strain of HSV-1 infection peaked as early as 4 h postinfection, then declined [3].
  • The hypoglycaemic effect of the plant extract (HCE) was examined in normal and diabetic rats, using a streptozotocin (STZ)-induced diabetes mellitus model [4].
  • Measurements were performed on 36 consecutive patients undergoing percutaneous transluminal angioplasty (PTA, n=18), transjugular intrahepatic portosystemic shunt (TIPS, n=3), diagnostic angiography (DA, n=6), arterial embolization (AE, n=3), and hepatic neoplasm chemoembolization (HCE, n=6) [5].
 

High impact information on RNGTT

 

Biological context of RNGTT

 

Anatomical context of RNGTT

 

Associations of RNGTT with chemical compounds

 

Co-localisations of RNGTT

  • Moreover, an immunofluorescent staining assay indicated that NDP52 colocalizes with HCAP1 in the cytoplasm [18].
 

Other interactions of RNGTT

  • By deletion analysis, the leucine zipper domain of HCAP1 and the zinc finger domain of NDP52 were identified as important regions responsible for the interaction [18].
 

Analytical, diagnostic and therapeutic context of RNGTT

  • RESULTS: The HCE 3.5 power analysis tool was designed to import any pre-existing Affymetrix microarray project, and interactively test the effects of user-defined definitions of alpha (significance), beta (1-power), sample size and effect size [20].
  • Based on immunoblotting analyses, HCE-1 was present in all tissues examined, whereas HCE-2 and HCE-3 were expressed in a tissue-restricted pattern [2].
  • RESULTS: Identities of primary cultures, human ciliary smooth muscle (HCSM), ciliary nonpigmented epithelial (HCE), and trabecular meshwork (HTM) cells were confirmed by immunocytochemistry, using cell-specific markers and observing typical cell morphologies [21].
  • Acute oral administrations of the plant extract (HCE, 50-800 mg/kg po) caused dose-related, significant (p < 0.05- 0.001) hypoglycaemia in normal (normoglycaemic) and STZ-treated diabetic rats [4].
  • HCE may be an excellent alternative cell line for the isolation of HSV-1, especially from corneal scrapings, for the laboratory diagnosis of HSK [22].

References

  1. The effect of diethylstilboestrol on the in vitro growth of human ectocervical cells. Johnstone, S.R., Stanley, M.A., Quigley, J.P. Carcinogenesis (1984) [Pubmed]
  2. Human and rodent carboxylesterases: immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, and tumor-related expression. Xie, M., Yang, D., Liu, L., Xue, B., Yan, B. Drug Metab. Dispos. (2002) [Pubmed]
  3. Neutrophil chemotaxis induced by corneal epithelial cells after herpes simplex virus type 1 infection. Miyazaki, D., Inoue, Y., Araki-Sasaki, K., Shimomura, Y., Tano, Y., Hayashi, K. Curr. Eye Res. (1998) [Pubmed]
  4. Hypoglycaemic and hypotensive effects of Harpephyllum caffrum Bernh ex CF Krauss (Anacardiaceae) stem-bark aqueous extract in rats. Ojewole, J.A. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners. (2006) [Pubmed]
  5. Patient radiation exposure measurements during interventional procedures: a prospective study. Efstathopoulos, E.P., Brountzos, E.N., Alexopoulou, E., Argentos, S., Kelekis, D.A., Raptou, P.D., Kelekis, N.L. Health physics. (2006) [Pubmed]
  6. mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain. Cho, E.J., Takagi, T., Moore, C.R., Buratowski, S. Genes Dev. (1997) [Pubmed]
  7. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. Pappa, A., Brown, D., Koutalos, Y., DeGregori, J., White, C., Vasiliou, V. J. Biol. Chem. (2005) [Pubmed]
  8. HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA. Chiu, Y.L., Coronel, E., Ho, C.K., Shuman, S., Rana, T.M. J. Biol. Chem. (2001) [Pubmed]
  9. Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the astacin family. Hung, C.H., Huang, H.R., Huang, C.J., Huang, F.L., Chang, G.D. J. Biol. Chem. (1997) [Pubmed]
  10. Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. Yamada-Okabe, T., Doi, R., Shimmi, O., Arisawa, M., Yamada-Okabe, H. Nucleic Acids Res. (1998) [Pubmed]
  11. Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B. Wan, D., He, M., Wang, J., Qiu, X., Zhou, W., Luo, Z., Chen, J., Gu, J. Genes Chromosomes Cancer (2004) [Pubmed]
  12. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. Shi, D., Yang, J., Yang, D., Lecluyse, E.L., Black, C., You, L., Akhlaghi, F., Yan, B. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  13. Evolution of teleostean hatching enzyme genes and their paralogous genes. Kawaguchi, M., Yasumasu, S., Hiroi, J., Naruse, K., Inoue, M., Iuchi, I. Dev. Genes Evol. (2006) [Pubmed]
  14. Growth requirements of human cervical epithelial cells in culture. Stanley, M.A., Parkinson, E.K. Int. J. Cancer (1979) [Pubmed]
  15. Dexamethasone differentially regulates expression of carboxylesterase genes in humans and rats. Zhu, W., Song, L., Zhang, H., Matoney, L., LeCluyse, E., Yan, B. Drug Metab. Dispos. (2000) [Pubmed]
  16. Up-regulation of phosphorylation of focal adhesion kinase and paxillin by combination of substance P and IGF-1 in SV-40 transformed human corneal epithelial cells. Nakamura, M., Nagano, T., Chikama, T., Nishida, T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  17. Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. Toropainen, E., Ranta, V.P., Vellonen, K.S., Palmgrén, J., Talvitie, A., Laavola, M., Suhonen, P., Hämäläinen, K.M., Auriola, S., Urtti, A. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2003) [Pubmed]
  18. HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins. Di, Y., Li, J., Zhang, Y., He, X., Lu, H., Xu, D., Ling, J., Huo, K., Wan, D., Li, Y.Y., Gu, J. J. Biochem. (2003) [Pubmed]
  19. The hatching gland cells of trout embryos: characterisation of N- and O-linked oligosaccharides. De Gaspar, I., Blanquez, M.J., Fraile, B., Paniagua, R., Arenas, M.I. J. Anat. (1999) [Pubmed]
  20. An interactive power analysis tool for microarray hypothesis testing and generation. Seo, J., Gordish-Dressman, H., Hoffman, E.P. Bioinformatics (2006) [Pubmed]
  21. Endothelin receptor A is expressed and mediates the [Ca2+]i mobilization of cells in human ciliary smooth muscle, ciliary nonpigmented epithelium, and trabecular meshwork. Tao, W., Prasanna, G., Dimitrijevich, S., Yorio, T. Curr. Eye Res. (1998) [Pubmed]
  22. Comparison of an immortalized human corneal epithelial cell line with Vero cells in the isolation of Herpes simplex virus-1 for the laboratory diagnosis of Herpes simplex keratitis. Athmanathan, S., Reddy, S.B., Nutheti, R., Rao, G.N. BMC ophthalmology [electronic resource]. (2002) [Pubmed]
 
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