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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CALCOCO2  -  calcium binding and coiled-coil domain 2

Bos taurus

 
 
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Disease relevance of NDP52

  • Confocal microscopic analyses of HeLa cells showed a time-dependent uncoating of capsids in cytoplasmic vesicles and the accumulation of both L2 and viral DNA at distinct nuclear domains identified as nuclear domain 10 (ND10) [1].
  • Since ND10 structures were recently hypothesized to be sites of bovine papillomavirus virion assembly, our observation suggests that HPV DNA amplification might be partially coupled to virion assembly [2].
 

High impact information on NDP52

  • We propose a model in which L2 chaperones the viral genome to ND10 to efficiently initiate viral transcription [1].
  • Northern blot analysis showed that the BC8 clone bovine NDP52 was predominantly expressed in tumor cell line BTL-26, compared with the transcripts from several bovine tissues [3].

References

  1. Establishment of papillomavirus infection is enhanced by promyelocytic leukemia protein (PML) expression. Day, P.M., Baker, C.C., Lowy, D.R., Schiller, J.T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Human papillomavirus DNA replication compartments in a transient DNA replication system. Swindle, C.S., Zou, N., Van Tine, B.A., Shaw, G.M., Engler, J.A., Chow, L.T. J. Virol. (1999) [Pubmed]
  3. Characterization of differentially expressed genes in the bovine T lymphoma cell line. Onodera, H., Ishiguro, N., Horiuchi, M., Shinagawa, M. Vet. Immunol. Immunopathol. (1998) [Pubmed]
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