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Gene Review:

rgpE - glycosyltransferase

Streptococcus mutans UA159

Shibata, Y. et al., Nomura, R. et al., Yamashita, Y. et al.

Yamashita, Tsukioka, Tomihisa, Nakano, Koga,

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Disease relevance of rgpE

However, E. coli carrying a plasmid with all of the rgp genes except for rgpE synthesized the rhamnan backbone of RGP without glucose side chains, suggesting that in addition to rgpE, another gene is required for glucose side-chain formation [1].

High impact information on rgpE

Rhamnose and glucose content of the cell wall decreased drastically in all these disruption mutants, except that in the rgpE mutant only the glucose content decreased [2].
Furthermore, mRNA expression of rgpE, known to be associated with glucose side chain formation, was not detected in any of the tested serotype k isolates with an RT-PCR method [3].

References

Expression and characterization of streptococcal rgp genes required for rhamnan synthesis in Escherichia coli. Shibata, Y., Yamashita, Y., Ozaki, K., Nakano, Y., Koga, T. Infect. Immun. (2002) [Pubmed]
Genes involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide in Streptococcus mutans. Yamashita, Y., Tsukioka, Y., Tomihisa, K., Nakano, Y., Koga, T. J. Bacteriol. (1998) [Pubmed]
Molecular analysis of the genes involved in the biosynthesis of serotype specific polysaccharide in the novel serotype k strains of Streptococcus mutans. Nomura, R., Nakano, K., Ooshima, T. Oral Microbiol. Immunol. (2005) [Pubmed]

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