Disease relevance of ampG

• Cells lacking either AmpG or AmpD lose up to 40% of their peptidoglycan per generation, whereas Escherichia coli normally suffers minimal losses and instead recycles 40 or 50% of the tripeptide, L-alanyl-D-glutamyl-meso-diaminopimelic acid, from its peptidoglycan each generation [1].

High impact information on ampG

• The deduced amino acid sequence predicted AmpG to be a 53 kDa, transmembrane protein, which we propose acts as a signal transducer or permease in the beta-lactamase induction system [2].
• Its uptake from the periplasm into the cytoplasm is carried out via the AmpG protein, an intrinsic membrane protein [3].
• Substrate specificity of the AmpG permease required for recycling of cell wall anhydro-muropeptides [4].
• AmpG permease is sensitive to carbonylcyanide m-chlorophenylhydrazone, demonstrating that AmpG permease is a single-component permease and that transport is dependent on the proton motive force [4].

Anatomical context of ampG

• The natural inducer, though not yet unequivocally identified, is a cell wall breakdown product which enters the cell via the AmpG permease component of the murein recycling pathway [5].

Analytical, diagnostic and therapeutic context of ampG

• AmpG, a signal transducer in chromosomal beta-lactamase induction [2].

References