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Gene Review

ampG  -  muropeptide transporter

Escherichia coli CFT073

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Disease relevance of ampG

  • Cells lacking either AmpG or AmpD lose up to 40% of their peptidoglycan per generation, whereas Escherichia coli normally suffers minimal losses and instead recycles 40 or 50% of the tripeptide, L-alanyl-D-glutamyl-meso-diaminopimelic acid, from its peptidoglycan each generation [1].

High impact information on ampG


Anatomical context of ampG

  • The natural inducer, though not yet unequivocally identified, is a cell wall breakdown product which enters the cell via the AmpG permease component of the murein recycling pathway [5].

Analytical, diagnostic and therapeutic context of ampG


  1. Bacterial cell wall recycling provides cytosolic muropeptides as effectors for beta-lactamase induction. Jacobs, C., Huang, L.J., Bartowsky, E., Normark, S., Park, J.T. EMBO J. (1994) [Pubmed]
  2. AmpG, a signal transducer in chromosomal beta-lactamase induction. Lindquist, S., Weston-Hafer, K., Schmidt, H., Pul, C., Korfmann, G., Erickson, J., Sanders, C., Martin, H.H., Normark, S. Mol. Microbiol. (1993) [Pubmed]
  3. Membrane topology of the Escherichia coli AmpG permease required for recycling of cell wall anhydromuropeptides and AmpC beta-lactamase induction. Chahboune, A., Decaffmeyer, M., Brasseur, R., Joris, B. Antimicrob. Agents Chemother. (2005) [Pubmed]
  4. Substrate specificity of the AmpG permease required for recycling of cell wall anhydro-muropeptides. Cheng, Q., Park, J.T. J. Bacteriol. (2002) [Pubmed]
  5. Role of the murein precursor UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala in repression of beta-lactamase induction in cell division mutants. Uehara, T., Park, J.T. J. Bacteriol. (2002) [Pubmed]
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